Gene · 27185
DISC1: DISC1 scaffold protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DISC1: DISC1 scaffold protein. Genes, record 27185. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27185
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NRI5 | Disrupted in schizophrenia 1 protein | 854 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 15029 | Q9NRI5 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 6585 | Q9NRI5 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 15029 | Q9NRI5 | Espacenet |
| JP 2025062601 A | 2025-04-14 | 34 | Q9NRI5 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 6585 | Q9NRI5 | Espacenet |
| US 11827937 B2 | 2023-11-28 | 64 | Q9NRI5 | Espacenet |
| EP 4180815 A2 | 2023-05-17 | 6 | Q9NRI5 | Espacenet |
| EP 4180816 A2 | 2023-05-17 | 6 | Q9NRI5 | Espacenet |
| JP 2022523514 A | 2022-04-25 | 34 | Q9NRI5 | Espacenet |
| JP 2022033877 A | 2022-03-02 | 3623 | Q9NRI5 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,033
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DISC1 papers | Newest fiscal year |
|---|---|---|---|
| R01MH071316 | Rac-GEF signaling in dendritic spines | 12 | 2025 |
| R01EB006841 | Multivariate methods for identifying multitask/multimodal brain imaging biomarkers | 10 | 2025 |
| R35NS116843 | Continuous Neurogenesis in the Mammalian Hippocampus | 7 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 6 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 4 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 4 | 2025 |
| R01MH106575 | Systematic Functional Interpretation of Regulatory Variants in Neuropsychiatric Disorders | 4 | 2025 |
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 4 | 2025 |
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 4 | 2025 |
| UL1TR002373 | University of Wisconsin Institute for Clinical and Translational Research | 4 | 2025 |
1 to 10 of 2,033Source NIH's project files
See all 2,033 nih grantsPapers2,570
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| DISC1 Orchestrates Mitochondrial Calcium Overload in Diabetic Encephalopathy Through a Dual Nucleocytoplasmic Mechanism. | Biomolecules | 2026 | 42793198 | PubTator, text mining | PubMed |
| Divergent microtubule-organizing center strategies in mammalian gametogenesis. | Trends Open | 2026 | 42761981 | PubTator, text mining | PubMed |
| RABV P protein activates the GSK3β-NF-κB signaling pathway to promote viral replication by interacting with the host protein Snapin. | J Virol | 2026 | 42742225 | PubTator, text mining | PubMed |
| Elevated Plasma DISC1 Levels Are Associated With Motivational Deficits in Medication-Free Patients With Major Depressive Disorder: An Exploratory Study. | Psych J | 2026 | 42732880 | PubTator, text mining | PubMed |
| Investigation of WNT2, DISC1, and DOCK4 polymorphisms in a Turkish autism spectrum disorder cohort: a case-control and bioinformatics analysis. | Mol Biol Rep | 2026 | 42627543 | PubTator, text mining | PubMed |
| Construction and Validation of an Early Diagnosis Model for Atherosclerosis Based on Lactate Metabolism-related Genes. | Curr Med Chem | 2026 | 42576558 | PubTator, text mining | PubMed |
| Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development. | Neuron | 2026 | 42471015 | PubTator, text mining | PubMed |
| Defining functional states and roles of microglia in neuropsychiatric disorders. | Front Cell Neurosci | 2026 | 42244505 | PubTator, text mining | PubMed |
| Epigenetic Evidence Implies Disturbed Proteostasis and Potentially Protein Aggregation in Suicidality. | Biomolecules | 2026 | 42194081 | PubTator, text mining | PubMed |
| DISC1 mutant macaques capture behavioral and neural hallmarks of psychiatric disease. | Natl Sci Rev | 2026 | 42130747 | PubTator, text mining | PubMed |
1 to 10 of 2,570
See all 2,570 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/27185
GET https://conductscience.org/api/genes/v1/27185/patents?page=2