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Gene · 27185

DISC1: DISC1 scaffold protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DISC1: DISC1 scaffold protein. Genes, record 27185. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27185

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Gene

Symbol
DISC1
HGNC
Name
DISC1 scaffold protein
HGNC
NCBI Gene ID
27185
NCBI Gene
HGNC ID
HGNC:2888
HGNC
Ensembl
ENSG00000162946
NCBI Gene
Aliases
C1orf136, SCZD9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NRI5Disrupted in schizophrenia 1 protein8541Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2915029Q9NRI5Espacenet
EP 4641202 A22025-10-296585Q9NRI5Espacenet
JP 2025517969 A2025-06-1215029Q9NRI5Espacenet
JP 2025062601 A2025-04-1434Q9NRI5Espacenet
KR 1020250017231 A2025-02-046585Q9NRI5Espacenet
US 11827937 B22023-11-2864Q9NRI5Espacenet
EP 4180815 A22023-05-176Q9NRI5Espacenet
EP 4180816 A22023-05-176Q9NRI5Espacenet
JP 2022523514 A2022-04-2534Q9NRI5Espacenet
JP 2022033877 A2022-03-023623Q9NRI5Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,033

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDISC1 papersNewest fiscal year
R01MH071316Rac-GEF signaling in dendritic spines122025
R01EB006841Multivariate methods for identifying multitask/multimodal brain imaging biomarkers102025
R35NS116843Continuous Neurogenesis in the Mammalian Hippocampus72025
UL1TR001863Yale Clinical and Translational Science Award62025
P30DK063491Diabetes Research Center (DRC)42025
P30ES010126UNC Center for Environmental Health and Susceptibility42025
R01MH106575Systematic Functional Interpretation of Regulatory Variants in Neuropsychiatric Disorders42025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).42025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)42025
UL1TR002373University of Wisconsin Institute for Clinical and Translational Research42025

1 to 10 of 2,033Source NIH's project files

See all 2,033 nih grants

Papers2,570

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DISC1 Orchestrates Mitochondrial Calcium Overload in Diabetic Encephalopathy Through a Dual Nucleocytoplasmic Mechanism.Biomolecules202642793198PubTator, text miningPubMed
Divergent microtubule-organizing center strategies in mammalian gametogenesis.Trends Open202642761981PubTator, text miningPubMed
RABV P protein activates the GSK3β-NF-κB signaling pathway to promote viral replication by interacting with the host protein Snapin.J Virol202642742225PubTator, text miningPubMed
Elevated Plasma DISC1 Levels Are Associated With Motivational Deficits in Medication-Free Patients With Major Depressive Disorder: An Exploratory Study.Psych J202642732880PubTator, text miningPubMed
Investigation of WNT2, DISC1, and DOCK4 polymorphisms in a Turkish autism spectrum disorder cohort: a case-control and bioinformatics analysis.Mol Biol Rep202642627543PubTator, text miningPubMed
Construction and Validation of an Early Diagnosis Model for Atherosclerosis Based on Lactate Metabolism-related Genes.Curr Med Chem202642576558PubTator, text miningPubMed
Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development.Neuron202642471015PubTator, text miningPubMed
Defining functional states and roles of microglia in neuropsychiatric disorders.Front Cell Neurosci202642244505PubTator, text miningPubMed
Epigenetic Evidence Implies Disturbed Proteostasis and Potentially Protein Aggregation in Suicidality.Biomolecules202642194081PubTator, text miningPubMed
DISC1 mutant macaques capture behavioral and neural hallmarks of psychiatric disease.Natl Sci Rev202642130747PubTator, text miningPubMed

1 to 10 of 2,570

See all 2,570 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/27185

GET https://conductscience.org/api/genes/v1/27185/patents?page=2