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GPC3: glypican 3

1 protein, 223 patents, 1 drug, 3 trials, 1,611 NIH grants and 6,119 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGPC3HGNC
Nameglypican 3HGNC
NCBI Gene ID2719NCBI Gene
HGNC IDHGNC:4451HGNC
EnsemblENSG00000147257NCBI Gene
AliasesDGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P51654Glypican-35804Ensembl, GeneID, HGNCUniProt

Patents 223

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4807363 A12026-09-161P51654Espacenet
WO 2026170216 A12026-08-131P51654Espacenet
WO 2026134203 A2026-06-25111P51654Espacenet
JP 2026103881 A2026-06-24134P51654Espacenet
US 12655230 B22026-06-16164P51654Espacenet
EP 4755457 A22026-06-10181P51654Espacenet
EP 4731753 A22026-04-2922P51654Espacenet
EP 4724457 A22026-04-15398P51654Espacenet
EP 4725968 A12026-04-1535P51654Espacenet
JP 2026065059 A2026-04-141241P51654Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CODRITUZUMABCHEMBL4298089Glypican-3 inhibitorINHIBITORChEMBL

Trials 3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01507168CODRITUZUMABPHASE2ClinicalTrials.gov
NCT00976170CODRITUZUMABPHASE1ClinicalTrials.gov
NCT00746317CODRITUZUMABPHASE1ClinicalTrials.gov

NIH grants 1611

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant362,025NIH's project files
ZIABC010891Development of antibody engineering-based cancer therapies352,025NIH's project files
P30CA016672Cancer Center Support Grant132,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease82,025NIH's project files
P50CA210964Mayo Clinic Hepatobiliary SPORE82,025NIH's project files
ZIABC010313Strategies for improving early detection, diagnosis and treatment of liver cancer82,025NIH's project files
P30CA016058Cancer Center Support Grant72,025NIH's project files
P30CA196521The Tisch Cancer Institute - Cancer Center Support Grant72,025NIH's project files
P30DK026743UCSF Liver Center72,025NIH's project files
P30DK084567Mayo Center for Cell Signaling in Gastroenterology72,025NIH's project files

Papers 6119

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42804101PubTator, text miningPubMed
42803813PubTator, text miningPubMed
42802838PubTator, text miningPubMed
42802204PubTator, text miningPubMed
42801020PubTator, text miningPubMed
42798324PubTator, text miningPubMed
42792683PubTator, text miningPubMed
42787143PubTator, text miningPubMed
42786871PubTator, text miningPubMed
42785950PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license