Gene · 27242
TNFRSF21: TNF receptor superfamily member 21
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TNFRSF21: TNF receptor superfamily member 21. Genes, record 27242. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27242
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O75509 | Tumor necrosis factor receptor superfamily member 21 | 655 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents261
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 3776 | O75509 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 16507 | O75509 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5009 | O75509 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5009 | O75509 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3776 | O75509 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 16507 | O75509 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 16507 | O75509 | Espacenet |
| JP 2024156868 A | 2024-11-06 | 17 | O75509 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 8884 | O75509 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 16346 | O75509 | Espacenet |
1 to 10 of 261
See all 261 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,049
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TNFRSF21 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30DK036836 | Diabetes Research Center | 3 | 2025 |
| U54MD007582 | FAMU Center for Health Disparities Research | 3 | 2025 |
| P01CA018029 | Adult Leukemia Research Center | 2 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016359 | Cancer Center Support Grant | 2 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 2 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 2 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 1,049Source NIH's project files
See all 1,049 nih grantsPapers1,638
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Elevated cytokines in osteoporotic blood correlate with immune microenvironment shifts and dysregulated circRNA profiles. | Front Immunol | 2026 | 42780614 | PubTator, text mining | PubMed |
| 1H, 15N and 13C resonance assignment of caspase recruitment domain of death receptor 6. | Biomol NMR Assign | 2026 | 42432288 | PubTator, text mining | PubMed |
| Identification of Differentially Expressed Genes in Non-functioning Pituitary Adenoma by Transcriptome Analysis. | In Vivo | 2026 | 42379758 | PubTator, text mining | PubMed |
| Association between HLA molecules and stage III/IV grade C periodontitis in a Moroccan population: A case-control study. | J Adv Periodontol Implant Dent | 2026 | 42267169 | PubTator, text mining | PubMed |
| Development and validation of a cuproptosis-immune prognostic signature for risk stratification and personalized therapy in cutaneous melanoma. | Discov Oncol | 2026 | 42262432 | PubTator, text mining | PubMed |
| Integrating machine learning and spatiotemporal transcriptomics to build a diagnostic model for osteosarcoma metastasis and to decipher the role of necroptosis genes. | Discov Oncol | 2026 | 42217132 | PubTator, text mining | PubMed |
| A natural coumarin, benjaminin, suppresses proliferation and migration and induces apoptosis in MCF-7 breast cancer cells. | Sci Rep | 2026 | 42177275 | PubTator, text mining | PubMed |
| The role and mechanism of TNFRSF21 in promoting necroptosis of vascular endothelial cells and inducing vascular leakage in sepsis. | J Mol Med (Berl) | 2026 | 42020785 | PubTator, text mining | PubMed |
| Identification of biomarkers associated with endoplasmic reticulum stress-related cell death in osteoporosis based on bulk and single-cell transcriptomic analyses and experimental validation. | Sci Rep | 2026 | 41905994 | PubTator, text mining | PubMed |
| Fragile histidine triad (FHIT) suppresses gastric cancer via translational regulation of the epigenetic modifier KDM6B. | J Biol Chem | 2026 | 41895442 | PubTator, text mining | PubMed |
1 to 10 of 1,638
See all 1,638 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/27242
GET https://conductscience.org/api/genes/v1/27242/patents?page=2