ConductScience.org, home

Gene · 27242

TNFRSF21: TNF receptor superfamily member 21

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. TNFRSF21: TNF receptor superfamily member 21. Genes, record 27242. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27242

On this page

Gene

Symbol
TNFRSF21
HGNC
Name
TNF receptor superfamily member 21
HGNC
NCBI Gene ID
27242
NCBI Gene
HGNC ID
HGNC:13469
HGNC
Ensembl
ENSG00000146072
NCBI Gene
Aliases
BM-018, CD358, DR6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75509Tumor necrosis factor receptor superfamily member 216557Ensembl, GeneID, HGNC

Source UniProt

Patents261

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193776O75509Espacenet
JP 2025147176 A2025-10-0616507O75509Espacenet
JP 2025529142 A2025-09-045009O75509Espacenet
US 12371689 B22025-07-295009O75509Espacenet
JP 2025517970 A2025-06-123776O75509Espacenet
JP 2025028160 A2025-02-2816507O75509Espacenet
KR 1020250010750 A2025-01-2116507O75509Espacenet
JP 2024156868 A2024-11-0617O75509Espacenet
JP 2024123008 A2024-09-108884O75509Espacenet
JP 2024109657 A2024-08-1416346O75509Espacenet

1 to 10 of 261

See all 261 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,049

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTNFRSF21 papersNewest fiscal year
P30CA008748Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30DK036836Diabetes Research Center32025
U54MD007582FAMU Center for Health Disparities Research32025
P01CA018029Adult Leukemia Research Center22025
P30CA015704Cancer Center Support Grant22025
P30CA016359Cancer Center Support Grant22025
P30CA021765Cancer Center Support Grant (CCSG)22025
P30CA023108Cancer Center Support Grant22025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant22025

1 to 10 of 1,049Source NIH's project files

See all 1,049 nih grants

Papers1,638

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Elevated cytokines in osteoporotic blood correlate with immune microenvironment shifts and dysregulated circRNA profiles.Front Immunol202642780614PubTator, text miningPubMed
1H, 15N and 13C resonance assignment of caspase recruitment domain of death receptor 6.Biomol NMR Assign202642432288PubTator, text miningPubMed
Identification of Differentially Expressed Genes in Non-functioning Pituitary Adenoma by Transcriptome Analysis.In Vivo202642379758PubTator, text miningPubMed
Association between HLA molecules and stage III/IV grade C periodontitis in a Moroccan population: A case-control study.J Adv Periodontol Implant Dent202642267169PubTator, text miningPubMed
Development and validation of a cuproptosis-immune prognostic signature for risk stratification and personalized therapy in cutaneous melanoma.Discov Oncol202642262432PubTator, text miningPubMed
Integrating machine learning and spatiotemporal transcriptomics to build a diagnostic model for osteosarcoma metastasis and to decipher the role of necroptosis genes.Discov Oncol202642217132PubTator, text miningPubMed
A natural coumarin, benjaminin, suppresses proliferation and migration and induces apoptosis in MCF-7 breast cancer cells.Sci Rep202642177275PubTator, text miningPubMed
The role and mechanism of TNFRSF21 in promoting necroptosis of vascular endothelial cells and inducing vascular leakage in sepsis.J Mol Med (Berl)202642020785PubTator, text miningPubMed
Identification of biomarkers associated with endoplasmic reticulum stress-related cell death in osteoporosis based on bulk and single-cell transcriptomic analyses and experimental validation.Sci Rep202641905994PubTator, text miningPubMed
Fragile histidine triad (FHIT) suppresses gastric cancer via translational regulation of the epigenetic modifier KDM6B.J Biol Chem202641895442PubTator, text miningPubMed

1 to 10 of 1,638

See all 1,638 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/27242

GET https://conductscience.org/api/genes/v1/27242/patents?page=2