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GCLC: glutamate-cysteine ligase catalytic subunit

1 protein, 25 patents, 0 drugs, 0 trials, 2,522 NIH grants and 5,933 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGCLCHGNC
Nameglutamate-cysteine ligase catalytic subunitHGNC
NCBI Gene ID2729NCBI Gene
HGNC IDHGNC:4311HGNC
EnsemblENSG00000001084NCBI Gene
AliasesCNSHA7, GCL, GCS, GLCL, GLCLCNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P48506Glutamate--cysteine ligase catalytic subunit6370Ensembl, GeneID, HGNCUniProt

Patents 25

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447828P48506Espacenet
EP 4650780 A22025-11-1919625P48506Espacenet
JP 2025529142 A2025-09-041683P48506Espacenet
US 12371689 B22025-07-291683P48506Espacenet
JP 2025517970 A2025-06-1219625P48506Espacenet
US 11446398 B22022-09-2035124P48506Espacenet
US 11400116 B22022-08-022391P48506Espacenet
JP 2022524081 A2022-04-27138095P48506Espacenet
US 11078247 B22021-08-034380P48506Espacenet
US 11015221 B22021-05-2542P48506Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2522

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant312,025NIH's project files
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment312,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center272,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant132,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase122,025NIH's project files
T32ES007091Training in Environmental Toxicology of Human Disease122,025NIH's project files
P30CA008748Cancer Center Support Grant112,025NIH's project files
P30CA086862Cancer Center Support Grant112,025NIH's project files
P30ES001247Environmental Agents as Modulators of Disease Processes112,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)112,025NIH's project files

Papers 5933

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822111PubTator, text miningPubMed
42773389PubTator, text miningPubMed
42749199PubTator, text miningPubMed
42735785PubTator, text miningPubMed
42724394PubTator, text miningPubMed
42687338PubTator, text miningPubMed
42633976PubTator, text miningPubMed
42620532PubTator, text miningPubMed
42617573PubTator, text miningPubMed
42568752PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license