Gene · 2730
GCLM: glutamate-cysteine ligase modifier subunit
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GCLM: glutamate-cysteine ligase modifier subunit. Genes, record 2730. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2730
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P48507 | Glutamate--cysteine ligase regulatory subunit | 274 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents41
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026094171 A | 2026-06-09 | 1 | P48507 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47829 | P48507 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8747 | P48507 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8747 | P48507 | Espacenet |
| JP 2025081326 A | 2025-05-27 | 43 | P48507 | Espacenet |
| JP 2023512287 A | 2023-03-24 | 2 | P48507 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 35133 | P48507 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 138104 | P48507 | Espacenet |
| US 11066709 B2 | 2021-07-20 | 43 | P48507 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 1057 | P48507 | Espacenet |
1 to 10 of 41
See all 41 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,486
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GCLM papers | Newest fiscal year |
|---|---|---|---|
| P30ES007033 | University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment | 40 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 36 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P30CA023074 | University of Arizona Cancer Center - Cancer Center Support Grant | 13 | 2025 |
| T32ES007091 | Training in Environmental Toxicology of Human Disease | 12 | 2025 |
| P42ES004940 | The DUST Center: Hazardous Dust in Drylands - Exposure, Health Impacts, and Mitigation | 10 | 2025 |
| T32AG052374 | USC-Buck Geroscience Training in the Biology of Aging | 9 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 6 | 2025 |
| P30ES005022 | Rutgers Center for Environmental Exposure and Disease (CEED) | 6 | 2025 |
| P30ES017885 | Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) | 6 | 2025 |
1 to 10 of 1,486Source NIH's project files
See all 1,486 nih grantsPapers2,672
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Key molecular networks underlying retinol's biphasic effects on cell proliferation through multi-omics integrative analysis using genome-scale metabolic modeling. | Synth Syst Biotechnol | 2027 | 42376007 | PubTator, text mining | PubMed |
| Protective effects of Oroxylum indicum seed extract against ultraviolet-induced skin photodamage through inhibition of STING and NF-κB signaling pathways. | Photochem Photobiol Sci | 2026 | 42773389 | PubTator, text mining | PubMed |
| PEPTIDE IDR-1002 REGULATES THE ANTIOXIDANT AND ANTI-INFLAMMATORY RESPONSES BY ACTIVATING THE KEAP1-NRF2 SIGNALING PATHWAY. | F1000Res | 2026 | 42728926 | PubTator, text mining | PubMed |
| Cantharidin Causes Hepatotoxicity by Disrupting GSH-Mediated Redox Homeostasis. | J Appl Toxicol | 2026 | 42633976 | PubTator, text mining | PubMed |
| Placental PRDX2-VEGFA/ENG network rewiring links oxidative stress to angiogenic failure in preeclampsia: A multi-cohort transcriptomic study. | Comput Biol Chem | 2026 | 42603350 | PubTator, text mining | PubMed |
| From oral decoction to intra-articular nanomedicine: Bawei Tiaosui Decoction (BWTSD) nanoparticle-laden lubricating hydrogel for synergistic treatment of knee osteoarthritis. | Mater Today Bio | 2026 | 42602932 | PubTator, text mining | PubMed |
| Redox-sensitive factors as targets of thiol compounds to hinder SARS-CoV-2 replication and inflammatory response. | Antimicrob Agents Chemother | 2026 | 42524834 | PubTator, text mining | PubMed |
| Role of Focal Adhesion Kinase and NRF2 Pathways in Gastrointestinal Wound Healing. | Int J Mol Sci | 2026 | 42511678 | PubTator, text mining | PubMed |
| Effects of cold water immersion versus active recovery on oxidative stress, redox gene expression and mitochondrial adaptations after strength training. | Exp Physiol | 2026 | 42487262 | PubTator, text mining | PubMed |
| Linkage-dependent effects of procyanidin dimers on TNFα-mediated intestinal epithelial barrier dysfunction, redox homeostasis and inflammation. | Food Funct | 2026 | 42370395 | PubTator, text mining | PubMed |
1 to 10 of 2,672
See all 2,672 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2730
GET https://conductscience.org/api/genes/v1/2730/patents?page=2