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Gene · 2730

GCLM: glutamate-cysteine ligase modifier subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GCLM: glutamate-cysteine ligase modifier subunit. Genes, record 2730. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2730

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Gene

Symbol
GCLM
HGNC
Name
glutamate-cysteine ligase modifier subunit
HGNC
NCBI Gene ID
2730
NCBI Gene
HGNC ID
HGNC:4312
HGNC
Ensembl
ENSG00000023909
NCBI Gene
Aliases
GLCLR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48507Glutamate--cysteine ligase regulatory subunit2740Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026094171 A2026-06-091P48507Espacenet
JP 2026004568 A2026-01-1447829P48507Espacenet
EP 4650780 A22025-11-198747P48507Espacenet
JP 2025517970 A2025-06-128747P48507Espacenet
JP 2025081326 A2025-05-2743P48507Espacenet
JP 2023512287 A2023-03-242P48507Espacenet
US 11446398 B22022-09-2035133P48507Espacenet
JP 2022524081 A2022-04-27138104P48507Espacenet
US 11066709 B22021-07-2043P48507Espacenet
WO 2020043864 A12020-03-051057P48507Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,486

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGCLM papersNewest fiscal year
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment402025
P30ES006694Southwest Environmental Health Sciences Center362025
P30CA016672Cancer Center Support Grant152025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant132025
T32ES007091Training in Environmental Toxicology of Human Disease122025
P42ES004940The DUST Center: Hazardous Dust in Drylands - Exposure, Health Impacts, and Mitigation102025
T32AG052374USC-Buck Geroscience Training in the Biology of Aging92025
P30CA006973Regional Oncology Research Center62025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)62025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)62025

1 to 10 of 1,486Source NIH's project files

See all 1,486 nih grants

Papers2,672

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Key molecular networks underlying retinol's biphasic effects on cell proliferation through multi-omics integrative analysis using genome-scale metabolic modeling.Synth Syst Biotechnol202742376007PubTator, text miningPubMed
Protective effects of Oroxylum indicum seed extract against ultraviolet-induced skin photodamage through inhibition of STING and NF-κB signaling pathways.Photochem Photobiol Sci202642773389PubTator, text miningPubMed
PEPTIDE IDR-1002 REGULATES THE ANTIOXIDANT AND ANTI-INFLAMMATORY RESPONSES BY ACTIVATING THE KEAP1-NRF2 SIGNALING PATHWAY.F1000Res202642728926PubTator, text miningPubMed
Cantharidin Causes Hepatotoxicity by Disrupting GSH-Mediated Redox Homeostasis.J Appl Toxicol202642633976PubTator, text miningPubMed
Placental PRDX2-VEGFA/ENG network rewiring links oxidative stress to angiogenic failure in preeclampsia: A multi-cohort transcriptomic study.Comput Biol Chem202642603350PubTator, text miningPubMed
From oral decoction to intra-articular nanomedicine: Bawei Tiaosui Decoction (BWTSD) nanoparticle-laden lubricating hydrogel for synergistic treatment of knee osteoarthritis.Mater Today Bio202642602932PubTator, text miningPubMed
Redox-sensitive factors as targets of thiol compounds to hinder SARS-CoV-2 replication and inflammatory response.Antimicrob Agents Chemother202642524834PubTator, text miningPubMed
Role of Focal Adhesion Kinase and NRF2 Pathways in Gastrointestinal Wound Healing.Int J Mol Sci202642511678PubTator, text miningPubMed
Effects of cold water immersion versus active recovery on oxidative stress, redox gene expression and mitochondrial adaptations after strength training.Exp Physiol202642487262PubTator, text miningPubMed
Linkage-dependent effects of procyanidin dimers on TNFα-mediated intestinal epithelial barrier dysfunction, redox homeostasis and inflammation.Food Funct202642370395PubTator, text miningPubMed

1 to 10 of 2,672

See all 2,672 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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