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Gene · 27329

ANGPTL3: angiopoietin like 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ANGPTL3: angiopoietin like 3. Genes, record 27329. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27329

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Gene

Symbol
ANGPTL3
HGNC
Name
angiopoietin like 3
HGNC
NCBI Gene ID
27329
NCBI Gene
HGNC ID
HGNC:491
HGNC
Ensembl
ENSG00000132855
NCBI Gene
Aliases
ANG-5, ANGPT5, ANL3, FHBL2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y5C1Angiopoietin-related protein 34601Ensembl, GeneID, HGNC

Source UniProt

Patents247

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11859Q9Y5C1Espacenet
JP 2026012737 A2026-01-272Q9Y5C1Espacenet
JP 2026004568 A2026-01-1437382Q9Y5C1Espacenet
EP 4650780 A22025-11-198903Q9Y5C1Espacenet
KR 1020250160515 A2025-11-132Q9Y5C1Espacenet
EP 4640849 A22025-10-291339Q9Y5C1Espacenet
EP 4641201 A22025-10-299134Q9Y5C1Espacenet
JP 2025147176 A2025-10-06814Q9Y5C1Espacenet
JP 2025529142 A2025-09-045479Q9Y5C1Espacenet
US 12371689 B22025-07-295479Q9Y5C1Espacenet

1 to 10 of 247

See all 247 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EVINACUMABCHEMBL3545191Angiopoietin-related protein 3 inhibitorINHIBITORChEMBL
VUPANORSENCHEMBL4298197Angiopoietin like 3 (ANGPTL3) mRNA antisense inhibitorANTISENSE INHIBITORChEMBL
VUPANORSEN SODIUMCHEMBL4298198Angiopoietin like 3 (ANGPTL3) mRNA antisense inhibitorANTISENSE INHIBITORChEMBL

Trials15

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07271186EVINACUMABPHASE2ClinicalTrials.gov
NCT05611528EVINACUMABPHASE3ClinicalTrials.gov
NCT04516291VUPANORSENPHASE22022-10-04ClinicalTrials.gov
NCT04459767VUPANORSENPHASE1ClinicalTrials.gov
NCT04233918EVINACUMABPHASE32023-06-07ClinicalTrials.gov
NCT03514420VUPANORSENPHASE22021-02-16ClinicalTrials.gov
NCT03455777VUPANORSENPHASE2ClinicalTrials.gov
NCT03452228EVINACUMABPHASE22023-02-16ClinicalTrials.gov
NCT03409744EVINACUMABPHASE32024-04-30ClinicalTrials.gov
NCT03399786EVINACUMABPHASE32021-05-18ClinicalTrials.gov

1 to 10 of 15

See all 15 trials

NIH grants1,362

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleANGPTL3 papersNewest fiscal year
P30DK017047Diabetes Research Center102025
P01HL151328Triglycerides, Diabetes and Cardiovascular Disease92025
P30DK063491Diabetes Research Center (DRC)82025
P30DK020572Michigan Diabetes Research Center (MDRC)62025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)52025
ZIAHG000024Genetic analysis of type II diabetes52025
ZIAHL006001Framingham Project/Levy52025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)42025
R01HL162698Regulation of Endothelial Lipase and HDL Metabolism by ANGPTL342025
R35HL150754Identifying new strategies for prevention of cardiovascular complications of diabetes42025

1 to 10 of 1,362Source NIH's project files

See all 1,362 nih grants

Papers2,231

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Features of Lipid Disorders in Cardiovascular-Kidney-Metabolic Syndrome.Int J Mol Sci202642794744PubTator, text miningPubMed
The Role of Angiopoietin-Like Proteins 3 and 4 and Their Target Lipases in CKD: A Drug-Target Mendelian Randomization Study.Am J Kidney Dis202642772348PubTator, text miningPubMed
Association of circulating ANGPTL3 level with all-cause and cardiovascular mortality.Int J Cardiol Cardiovasc Risk Prev202642761856PubTator, text miningPubMed
CRISPR therapy for dyslipidemia.Curr Opin Lipidol202642755348PubTator, text miningPubMed
Evinacumab Across Different Lipid Phenotypes: A Systematic Review and Meta-Analysis.Adv Ther202642742892PubTator, text miningPubMed
Expectations for Angiopoietin-like 3 Inhibitors Taking Broad Lipid-modifying Effects on the Comprehensive Control of Atherosclerotic Cardiovascular Disease Risk in Patients with Homozygous Familial Hypercholesterolemia.
J Atheroscler Thromb202642732948PubTator, text miningPubMed
Efficacy and Safety of Quarterly Dosing SHR-1918 in Patients With Suboptimally Controlled Hyperlipidemia.JACC Asia202642714362PubTator, text miningPubMed
Precision genome editing strategies for enduring lipid lowering in atherosclerosis.Eur J Pharmacol202642692283PubTator, text miningPubMed
Durability of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 with CTX310.N Engl J Med202642663980PubTator, text miningPubMed
Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?J Intern Med202642657470PubTator, text miningPubMed

1 to 10 of 2,231

See all 2,231 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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