Gene · 27329
ANGPTL3: angiopoietin like 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ANGPTL3: angiopoietin like 3. Genes, record 27329. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27329
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9Y5C1 | Angiopoietin-related protein 3 | 460 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents247
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4705273 A2 | 2026-03-11 | 859 | Q9Y5C1 | Espacenet |
| JP 2026012737 A | 2026-01-27 | 2 | Q9Y5C1 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 37382 | Q9Y5C1 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8903 | Q9Y5C1 | Espacenet |
| KR 1020250160515 A | 2025-11-13 | 2 | Q9Y5C1 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1339 | Q9Y5C1 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 9134 | Q9Y5C1 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 814 | Q9Y5C1 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5479 | Q9Y5C1 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5479 | Q9Y5C1 | Espacenet |
1 to 10 of 247
See all 247 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| EVINACUMAB | CHEMBL3545191 | Angiopoietin-related protein 3 inhibitor | INHIBITOR | ChEMBL |
| VUPANORSEN | CHEMBL4298197 | Angiopoietin like 3 (ANGPTL3) mRNA antisense inhibitor | ANTISENSE INHIBITOR | ChEMBL |
| VUPANORSEN SODIUM | CHEMBL4298198 | Angiopoietin like 3 (ANGPTL3) mRNA antisense inhibitor | ANTISENSE INHIBITOR | ChEMBL |
Trials15
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07271186 | EVINACUMAB | PHASE2 | ClinicalTrials.gov | |
| NCT05611528 | EVINACUMAB | PHASE3 | ClinicalTrials.gov | |
| NCT04516291 | VUPANORSEN | PHASE2 | 2022-10-04 | ClinicalTrials.gov |
| NCT04459767 | VUPANORSEN | PHASE1 | ClinicalTrials.gov | |
| NCT04233918 | EVINACUMAB | PHASE3 | 2023-06-07 | ClinicalTrials.gov |
| NCT03514420 | VUPANORSEN | PHASE2 | 2021-02-16 | ClinicalTrials.gov |
| NCT03455777 | VUPANORSEN | PHASE2 | ClinicalTrials.gov | |
| NCT03452228 | EVINACUMAB | PHASE2 | 2023-02-16 | ClinicalTrials.gov |
| NCT03409744 | EVINACUMAB | PHASE3 | 2024-04-30 | ClinicalTrials.gov |
| NCT03399786 | EVINACUMAB | PHASE3 | 2021-05-18 | ClinicalTrials.gov |
1 to 10 of 15
See all 15 trialsNIH grants1,362
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ANGPTL3 papers | Newest fiscal year |
|---|---|---|---|
| P30DK017047 | Diabetes Research Center | 10 | 2025 |
| P01HL151328 | Triglycerides, Diabetes and Cardiovascular Disease | 9 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 8 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 6 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 5 | 2025 |
| ZIAHG000024 | Genetic analysis of type II diabetes | 5 | 2025 |
| ZIAHL006001 | Framingham Project/Levy | 5 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 4 | 2025 |
| R01HL162698 | Regulation of Endothelial Lipase and HDL Metabolism by ANGPTL3 | 4 | 2025 |
| R35HL150754 | Identifying new strategies for prevention of cardiovascular complications of diabetes | 4 | 2025 |
1 to 10 of 1,362Source NIH's project files
See all 1,362 nih grantsPapers2,231
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Features of Lipid Disorders in Cardiovascular-Kidney-Metabolic Syndrome. | Int J Mol Sci | 2026 | 42794744 | PubTator, text mining | PubMed |
| The Role of Angiopoietin-Like Proteins 3 and 4 and Their Target Lipases in CKD: A Drug-Target Mendelian Randomization Study. | Am J Kidney Dis | 2026 | 42772348 | PubTator, text mining | PubMed |
| Association of circulating ANGPTL3 level with all-cause and cardiovascular mortality. | Int J Cardiol Cardiovasc Risk Prev | 2026 | 42761856 | PubTator, text mining | PubMed |
| CRISPR therapy for dyslipidemia. | Curr Opin Lipidol | 2026 | 42755348 | PubTator, text mining | PubMed |
| Evinacumab Across Different Lipid Phenotypes: A Systematic Review and Meta-Analysis. | Adv Ther | 2026 | 42742892 | PubTator, text mining | PubMed |
Expectations for Angiopoietin-like 3 Inhibitors Taking Broad Lipid-modifying Effects on the Comprehensive Control of Atherosclerotic Cardiovascular Disease Risk in Patients with Homozygous Familial Hypercholesterolemia. | J Atheroscler Thromb | 2026 | 42732948 | PubTator, text mining | PubMed |
| Efficacy and Safety of Quarterly Dosing SHR-1918 in Patients With Suboptimally Controlled Hyperlipidemia. | JACC Asia | 2026 | 42714362 | PubTator, text mining | PubMed |
| Precision genome editing strategies for enduring lipid lowering in atherosclerosis. | Eur J Pharmacol | 2026 | 42692283 | PubTator, text mining | PubMed |
| Durability of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 with CTX310. | N Engl J Med | 2026 | 42663980 | PubTator, text mining | PubMed |
| Hypocholesterolemia in liver and cardiovascular disease: Friend or foe? | J Intern Med | 2026 | 42657470 | PubTator, text mining | PubMed |
1 to 10 of 2,231
See all 2,231 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/27329
GET https://conductscience.org/api/genes/v1/27329/patents?page=2