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Gene · 2737

GLI3: GLI family zinc finger 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GLI3: GLI family zinc finger 3. Genes, record 2737. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2737

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Gene

Symbol
GLI3
HGNC
Name
GLI family zinc finger 3
HGNC
NCBI Gene ID
2737
NCBI Gene
HGNC ID
HGNC:4319
HGNC
Ensembl
ENSG00000106571
NCBI Gene
Aliases
ACLS, GCPS, GLI3-190, GLI3FL, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P10071Transcription activator GLI31,5801Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447570P10071Espacenet
EP 4650780 A22025-11-1911337P10071Espacenet
EP 4641201 A22025-10-2911816P10071Espacenet
JP 2025155288 A2025-10-142P10071Espacenet
JP 2025147176 A2025-10-0615045P10071Espacenet
JP 2025521922 A2025-07-1061P10071Espacenet
JP 2025517969 A2025-06-1211816P10071Espacenet
JP 2025517970 A2025-06-1211337P10071Espacenet
JP 2025032204 A2025-03-1129068P10071Espacenet
JP 2025028160 A2025-02-2815045P10071Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,274

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGLI3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant172025
ZIAHG200328Rare & Mosaic Disorders Molecular Research162025
P30CA016672Cancer Center Support Grant132025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology102025
R01HD073151Cis-regulatory circuitry underlying Hedgehog mediated limb development92025
P30CA021765Cancer Center Support Grant (CCSG)62025
P30CA023108Cancer Center Support Grant62025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202862025
R01GM060992Intraflagellar Transport Proteins in Mice62025
R35GM118063Cell signaling in development and regeneration62025

1 to 10 of 2,274Source NIH's project files

See all 2,274 nih grants

Papers3,698

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic landscape of pediatric seizures in Southeast China: identification of a novel GLI3 frameshift variant through whole-exome sequencing.Ann Med Surg (Lond)202642724907PubTator, text miningPubMed
Sharp cell type boundaries emerge from coordinated morphogen signaling.Genes Dev202642722434PubTator, text miningPubMed
Molecular insights into uterine fibroids: crosstalk between SHH and Wnt pathways, DNA methylation, and miRNAs regulation.Mol Genet Genomics202642667406PubTator, text miningPubMed
Epigenetic modulation of stromal cell states underpins pathological tissue niches in Crohn's disease.Nat Immunol202642587037PubTator, text miningPubMed
Stable overexpression of Nup88 enhances HeLa cell migration through independent regulation of Kif7 and Gli1.Oncol Rep202642495774PubTator, text miningPubMed
GLI3 in cancer: a context-dependent regulator with diagnostic, prognostic, and therapeutic potential.Front Immunol202642488637PubTator, text miningPubMed
Genomic Landscape and Perinatal Outcomes of Fetal Polydactyly: A Retrospective Cohort Study Integrating CNV-seq and Trio-ES.Prenat Diagn202642390887PubTator, text miningPubMed
MIRAGE: a multimodal deep learning framework for interpretable risk assessment of high myopia from genetic and retinal imaging data.Hum Mol Genet202642262223PubTator, text miningPubMed
Reciprocal Regulation of GLI1 and GLI3 Fine Tunes the Pathogenic Behavior of Synovial Fibroblasts in Rheumatoid Arthritis.Int J Rheum Dis202642246142PubTator, text miningPubMed
Novel MYH11::GLI3 fusion in ileal leiomyoma.Pathol Oncol Res202642051689PubTator, text miningPubMed

1 to 10 of 3,698

See all 3,698 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2737

GET https://conductscience.org/api/genes/v1/2737/patents?page=2