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Gene · 2739

GLO1: glyoxalase I

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GLO1: glyoxalase I. Genes, record 2739. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2739

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Gene

Symbol
GLO1
HGNC
Name
glyoxalase I
HGNC
NCBI Gene ID
2739
NCBI Gene
HGNC ID
HGNC:4323
HGNC
Ensembl
ENSG00000124767
NCBI Gene
Aliases
GLOD1, GLYI, HEL-S-74
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q04760Lactoylglutathione lyase18416Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448079Q04760Espacenet
EP 4650780 A22025-11-199300Q04760Espacenet
JP 2025517970 A2025-06-129300Q04760Espacenet
US 12023385 B22024-07-0243Q04760Espacenet
EP 4119552 A12023-01-1857Q04760Espacenet
US 11446398 B22022-09-2035805Q04760Espacenet
JP 2022524081 A2022-04-27138776Q04760Espacenet
US 11311609 B22022-04-2657Q04760Espacenet
US 11293023 B22022-04-0543Q04760Espacenet
US 11078247 B22021-08-034494Q04760Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants848

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGLO1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant122025
P30ES006694Southwest Environmental Health Sciences Center92025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant62025
P30EY011373CWRU NEI Vision Center Core Grant62025
P40OD010440Caenorhabditis Genetics Center62025
P30CA016672Cancer Center Support Grant52025
T32ES007091Training in Environmental Toxicology of Human Disease52025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025

1 to 10 of 848Source NIH's project files

See all 848 nih grants

Papers2,767

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The glycolytic metabolite methylglyoxal drives axon degeneration in vitro and in vivo.Exp Neurol202742759686PubTator, text miningPubMed
Metabolic targeting by a small extracellular vesicle-based cellulose-GelMA hydrogel restores neurovascular regeneration in diabetic nerve injury.Bioact Mater202742699320PubTator, text miningPubMed
Female-specific associations of glyoxalase 1 polymorphisms with schizophrenia in a Han Chinese case-control study.Psychiatr Genet202642820377PubTator, text miningPubMed
Glyoxalase I inhibition by TLSC702 sensitizes glyoxalase I-dependent cancer cells to doxorubicin-induced cell death.J Toxicol Sci202642816376PubTator, text miningPubMed
Optimization of a bis-imine scaffold as a glyoxalase I inhibitor: synthesis, SAR, and docking studies.Med Chem Res202642803812PubTator, text miningPubMed
High-Throughput Characterization of Human Fibroblast Responses to a Panel of Staphylococcus aureus Antigen Proteins Using Olink Proteomics.Open Forum Infect Dis202642751267PubTator, text miningPubMed
Identification of angiogenesis-related genes in the diagnosis of benign prostatic hyperplasia using bioinformatics analysis.Transl Androl Urol202642729026PubTator, text miningPubMed
An Integrated Analysis of Manganese Metabolism-Related Genes and Their Association With Biomarkers, Immune Infiltration, and Clinical Subtypes in Alzheimer's Disease.Genes Brain Behav202642723412PubTator, text miningPubMed
Structural Optimisation of an Amphibian BBI-Type Peptide Enhances Endothelial Protection Against Methylglyoxal-Induced Injury Through Coordinated Regulation of Glyoxalase-Mediated Detoxification and Redox Homeostasis.
Biomolecules202642650823PubTator, text miningPubMed
Methylglyoxal as a Convergent Mediator of Diabetic Complications: Generation, Protein Targets, Tissue Distribution, and Therapeutic Reduction-A Clinically Oriented Mechanistic Synthesis.Biomolecules202642650772PubTator, text miningPubMed

1 to 10 of 2,767

See all 2,767 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2739

GET https://conductscience.org/api/genes/v1/2739/patents?page=2