Gene · 274
BIN1: bridging integrator 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. BIN1: bridging integrator 1. Genes, record 274. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/274
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O00499 | Myc box-dependent-interacting protein 1 | 593 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents41
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4805378 A1 | 2026-09-16 | 102 | O00499 | Espacenet |
| JP 2026523341 A | 2026-07-14 | 561 | O00499 | Espacenet |
| EP 4771137 A1 | 2026-07-08 | 99 | O00499 | Espacenet |
| EP 4771157 A1 | 2026-07-08 | 99 | O00499 | Espacenet |
| US 12649003 B2 | 2026-06-09 | 561 | O00499 | Espacenet |
| JP 2026510339 A | 2026-04-02 | 99 | O00499 | Espacenet |
| EP 4713451 A2 | 2026-03-25 | 99 | O00499 | Espacenet |
| EP 4713452 A2 | 2026-03-25 | 99 | O00499 | Espacenet |
| US 12558437 B2 | 2026-02-24 | 561 | O00499 | Espacenet |
| EP 4677082 A2 | 2026-01-14 | 99 | O00499 | Espacenet |
1 to 10 of 41
See all 41 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,709
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | BIN1 papers | Newest fiscal year |
|---|---|---|---|
| U24AG021886 | National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) | 111 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 26 | 2025 |
| P01AG026276 | Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study | 24 | 2025 |
| U24AG041689 | THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE | 17 | 2025 |
| R01NS017950 | Precursors of Stroke Incidence and Prognosis | 16 | 2025 |
| U24AG056270 | National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS) | 16 | 2025 |
| P30AG066509 | University of Washington Alzheimer's Disease Research Center | 14 | 2025 |
| P30AG072975 | Rush Alzheimer's Disease Research Center | 13 | 2025 |
| U19AG024904 | Alzheimer's Disease Neuroimaging Initiative (ADNI4) | 13 | 2025 |
| U54AG052427 | Genome Center for Alzheimer's Disease (GCAD) | 12 | 2025 |
1 to 10 of 2,709Source NIH's project files
See all 2,709 nih grantsPapers2,900
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Molecular and genetic basis of alzheimer's disease and emerging treatment Modalities. | Neurodegener Dis Manag | 2026 | 42825454 | PubTator, text mining | PubMed |
| BAG3 coordinates astrocytic proteostasis of Alzheimer's disease-linked proteins via proteasome, autophagy, and retromer interactions. | Proc Natl Acad Sci U S A | 2026 | 42804638 | PubTator, text mining | PubMed |
| Genetic Determinants of Tau-PET Imaging in Alzheimer's Disease: A Narrative Review of Genome-Wide and Candidate-Gene Studies. | J Imaging | 2026 | 42783847 | PubTator, text mining | PubMed |
| Integration of cell-specific gene expression and chromatin accessibility facilitates localization of neurodegenerative risk in microglia. | bioRxiv | 2026 | 42780032 | PubTator, text mining | PubMed |
| Multi-omics integration of transcriptomics and metabolomics with machine learning uncovers novel risk factors for Alzheimer's disease. | J Alzheimers Dis | 2026 | 42758029 | PubTator, text mining | PubMed |
| Interpretable multimodal learning for integrating neuroimaging and genetic data in Alzheimer's disease. | Front Radiol | 2026 | 42707167 | PubTator, text mining | PubMed |
| AGG repeat expansion and aggregation of BIN1 in multiple system atrophy. | Brain | 2026 | 42663379 | PubTator, text mining | PubMed |
| RNA Splicing Dysregulation in Parkinson's Disease. | Genes (Basel) | 2026 | 42650103 | PubTator, text mining | PubMed |
| From adolescence to Alzheimer's: a neurodevelopmental lifespan model of cognitive vulnerability. | Neurol Sci | 2026 | 42645564 | PubTator, text mining | PubMed |
| DENND3-p.R534S disrupts dyadic microdomain architecture to drive potentially pro-arrhythmic calcium and electrophysiologic instability. | Europace | 2026 | 42639838 | PubTator, text mining | PubMed |
1 to 10 of 2,900
See all 2,900 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/274
GET https://conductscience.org/api/genes/v1/274/patents?page=2