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Gene · 274

BIN1: bridging integrator 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BIN1: bridging integrator 1. Genes, record 274. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/274

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Gene

Symbol
BIN1
HGNC
Name
bridging integrator 1
HGNC
NCBI Gene ID
274
NCBI Gene
HGNC ID
HGNC:1052
HGNC
Ensembl
ENSG00000136717
NCBI Gene
Aliases
AMPH2, AMPHL, CNM2, SH3P9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00499Myc box-dependent-interacting protein 15937Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4805378 A12026-09-16102O00499Espacenet
JP 2026523341 A2026-07-14561O00499Espacenet
EP 4771137 A12026-07-0899O00499Espacenet
EP 4771157 A12026-07-0899O00499Espacenet
US 12649003 B22026-06-09561O00499Espacenet
JP 2026510339 A2026-04-0299O00499Espacenet
EP 4713451 A22026-03-2599O00499Espacenet
EP 4713452 A22026-03-2599O00499Espacenet
US 12558437 B22026-02-24561O00499Espacenet
EP 4677082 A22026-01-1499O00499Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,709

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBIN1 papersNewest fiscal year
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)1112025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions262025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study242025
U24AG041689THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE172025
R01NS017950Precursors of Stroke Incidence and Prognosis162025
U24AG056270National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS)162025
P30AG066509University of Washington Alzheimer's Disease Research Center142025
P30AG072975Rush Alzheimer's Disease Research Center132025
U19AG024904Alzheimer's Disease Neuroimaging Initiative (ADNI4)132025
U54AG052427Genome Center for Alzheimer's Disease (GCAD)122025

1 to 10 of 2,709Source NIH's project files

See all 2,709 nih grants

Papers2,900

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Molecular and genetic basis of alzheimer's disease and emerging treatment Modalities.Neurodegener Dis Manag202642825454PubTator, text miningPubMed
BAG3 coordinates astrocytic proteostasis of Alzheimer's disease-linked proteins via proteasome, autophagy, and retromer interactions.Proc Natl Acad Sci U S A202642804638PubTator, text miningPubMed
Genetic Determinants of Tau-PET Imaging in Alzheimer's Disease: A Narrative Review of Genome-Wide and Candidate-Gene Studies.J Imaging202642783847PubTator, text miningPubMed
Integration of cell-specific gene expression and chromatin accessibility facilitates localization of neurodegenerative risk in microglia.bioRxiv202642780032PubTator, text miningPubMed
Multi-omics integration of transcriptomics and metabolomics with machine learning uncovers novel risk factors for Alzheimer's disease.J Alzheimers Dis202642758029PubTator, text miningPubMed
Interpretable multimodal learning for integrating neuroimaging and genetic data in Alzheimer's disease.Front Radiol202642707167PubTator, text miningPubMed
AGG repeat expansion and aggregation of BIN1 in multiple system atrophy.Brain202642663379PubTator, text miningPubMed
RNA Splicing Dysregulation in Parkinson's Disease.Genes (Basel)202642650103PubTator, text miningPubMed
From adolescence to Alzheimer's: a neurodevelopmental lifespan model of cognitive vulnerability.Neurol Sci202642645564PubTator, text miningPubMed
DENND3-p.R534S disrupts dyadic microdomain architecture to drive potentially pro-arrhythmic calcium and electrophysiologic instability.Europace202642639838PubTator, text miningPubMed

1 to 10 of 2,900

See all 2,900 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/274

GET https://conductscience.org/api/genes/v1/274/patents?page=2