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GLP1R: glucagon like peptide 1 receptor

1 protein, 65 patents, 17 drugs, 1,383 trials, 6,422 NIH grants and 34,487 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGLP1RHGNC
Nameglucagon like peptide 1 receptorHGNC
NCBI Gene ID2740NCBI Gene
HGNC IDHGNC:4324HGNC
EnsemblENSG00000112164NCBI Gene
AliasesGLP-1, GLP-1-R, GLP-1RNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P43220Glucagon-like peptide 1 receptor46371Ensembl, GeneID, HGNCUniProt

Patents 65

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777830 A12026-07-228P43220Espacenet
JP 2026004568 A2026-01-1447606P43220Espacenet
EP 4650780 A22025-11-199283P43220Espacenet
WO 2025227129 A22025-10-3026P43220Espacenet
EP 4640849 A22025-10-291386P43220Espacenet
EP 4641201 A22025-10-299511P43220Espacenet
JP 2025532651 A2025-10-0120P43220Espacenet
JP 2025529142 A2025-09-041738P43220Espacenet
US 12371689 B22025-07-291738P43220Espacenet
JP 2025519096 A2025-06-241386P43220Espacenet

Drugs 17

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALBIGLUTIDECHEMBL2107841Glucagon-like peptide 1 receptor agonistAGONISTChEMBL
AVEXITIDECHEMBL4297949Glucagon-like peptide 1 receptor antagonistANTAGONISTChEMBL
COTADUTIDECHEMBL4297630Glucagon-like peptide 1 receptor agonistAGONISTChEMBL
DANUGLIPRONCHEMBL4518483Glucagon-like peptide 1 receptor agonistAGONISTChEMBL
DULAGLUTIDECHEMBL2108027Glucagon-like peptide 1 receptor agonistAGONISTChEMBL
EFINOPEGDUTIDECHEMBL4297576Glucagon-like peptide 1 receptor agonistAGONISTChEMBL
EFPEGLENATIDECHEMBL4650470Glucagon-like peptide 1 receptor agonistAGONISTChEMBL
EXENATIDECHEMBL414357Glucagon-like peptide 1 receptor agonistAGONISTChEMBL
LIRAGLUTIDECHEMBL4084119Glucagon-like peptide 1 receptor agonistAGONISTChEMBL
LIXISENATIDECHEMBL2108336Glucagon-like peptide 1 receptor agonistAGONISTChEMBL

Trials 1383

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605247TIRZEPATIDEPHASE2ClinicalTrials.gov
NCT07602699TIRZEPATIDEPHASE2ClinicalTrials.gov
NCT07599046SEMAGLUTIDEClinicalTrials.gov
NCT07590219LIRAGLUTIDEPHASE4ClinicalTrials.gov
NCT07589322SEMAGLUTIDEClinicalTrials.gov
NCT07589322TIRZEPATIDEClinicalTrials.gov
NCT07588984SEMAGLUTIDEClinicalTrials.gov
NCT07588984TIRZEPATIDEClinicalTrials.gov
NCT07588438TIRZEPATIDEPHASE4ClinicalTrials.gov
NCT07586150SEMAGLUTIDEClinicalTrials.gov

NIH grants 6422

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK020572Michigan Diabetes Research Center (MDRC)732,025NIH's project files
P30DK036836Diabetes Research Center622,025NIH's project files
P30DK017047Diabetes Research Center542,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)492,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award462,025NIH's project files
P30DK020593Vanderbilt Diabetes Research Center452,025NIH's project files
U54GM104940Louisiana Clinical and Translational Science Center392,025NIH's project files
P30DK026687New York Obesity Research Center372,025NIH's project files
P30DK020595Diabetes Research and Training Center362,025NIH's project files
P30DK020579Diabetes Research Center322,025NIH's project files

Papers 34487

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827061PubTator, text miningPubMed
42826315PubTator, text miningPubMed
42825372PubTator, text miningPubMed
42824923PubTator, text miningPubMed
42823960PubTator, text miningPubMed
42823936PubTator, text miningPubMed
42823625PubTator, text miningPubMed
42823599PubTator, text miningPubMed
42823485PubTator, text miningPubMed
42823110PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license