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Gene · 27429

HTRA2: HtrA serine peptidase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HTRA2: HtrA serine peptidase 2. Genes, record 27429. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27429

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Gene

Symbol
HTRA2
HGNC
Name
HtrA serine peptidase 2
HGNC
NCBI Gene ID
27429
NCBI Gene
HGNC ID
HGNC:14348
HGNC
Ensembl
ENSG00000115317
NCBI Gene
Aliases
MGCA8, OMI, PARK13, PRSS25
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43464Serine protease HTRA2, mitochondrial45813Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449420O43464Espacenet
EP 4650780 A22025-11-191663O43464Espacenet
EP 4641201 A22025-10-291274O43464Espacenet
JP 2025529142 A2025-09-042017O43464Espacenet
US 12371689 B22025-07-292017O43464Espacenet
JP 2025517969 A2025-06-121274O43464Espacenet
JP 2025517970 A2025-06-121663O43464Espacenet
EP 4484957 A12025-01-01138O43464Espacenet
JP 2024112982 A2024-08-214341O43464Espacenet
WO 2023162878 A2023-08-31138O43464Espacenet

1 to 10 of 56

See all 56 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,159

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTRA2 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)52025
R01NS101628Dendrite regulation by the mitochondrial kinase PINK1: Implications for PD/LBD32025
UL1TR001863Yale Clinical and Translational Science Award32025
K12CA090628Paul Calabresi Program in Clinical/Translational Research at Mayo Clinic22025
P30CA008748Cancer Center Support Grant22025
P30CA016058Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30CA047904Cancer Center Support Grant22025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment22025
P30ES013508Center of Excellence in Environmental Toxicology22025

1 to 10 of 1,159Source NIH's project files

See all 1,159 nih grants

Papers2,128

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Benzamil-induced cytotoxicity in non-small cell lung cancer is associated with mitochondrial damage, mitochondrial elongation, and altered XIAP signaling.J Pharmacol Sci202642810781PubTator, text miningPubMed
Context-dependent roles of HtrA2/Omi in ovarian cancer: mitochondrial apoptotic function linking platinum sensitivity and acquired chemoresistance-a narrative review.Transl Cancer Res202642724498PubTator, text miningPubMed
Novel Clinical and Neurophysiological Insights in Neonatal-Onset 3-Methylglutaconic Aciduria Type VIII due to HTRA2 Mutations.Mol Genet Genomic Med202642581774PubTator, text miningPubMed
Host and Helicobacter pylori HtrA protease variants converge on Wnt/β-catenin signaling to drive stomach adenocarcinoma.Gut Microbes202642493827PubTator, text miningPubMed
Gene burden meta-analysis of 748 879 individuals identifies LGI1-ADAM23 protein complex association with epilepsy.Epilepsia202642216960PubTator, text miningPubMed
MASQ: A multiplex qPCR platform for quantitative alternative splicing analysis in clinical specimens.Mol Ther Nucleic Acids202642023028PubTator, text miningPubMed
Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications.Signal Transduct Target Ther202641881983PubTator, text miningPubMed
DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalk.Front Cardiovasc Med202641798622PubTator, text miningPubMed
Essential tremor: Family-based sequencing suggests involvement of neuronal and metabolic pathways.Parkinsonism Relat Disord202641762786PubTator, text miningPubMed
Erica spiculifolia Extract Potentiates Cisplatin Cytotoxicity by Reactivating p53 and Caspase-3-Dependent Apoptosis in Colorectal Carcinoma.Molecules202641752487PubTator, text miningPubMed

1 to 10 of 2,128

See all 2,128 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/27429

GET https://conductscience.org/api/genes/v1/27429/patents?page=2