Gene · 27429
HTRA2: HtrA serine peptidase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HTRA2: HtrA serine peptidase 2. Genes, record 27429. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/27429
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43464 | Serine protease HTRA2, mitochondrial | 458 | 13 | Ensembl, GeneID, HGNC |
Source UniProt
Patents56
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 49420 | O43464 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1663 | O43464 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1274 | O43464 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2017 | O43464 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2017 | O43464 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1274 | O43464 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1663 | O43464 | Espacenet |
| EP 4484957 A1 | 2025-01-01 | 138 | O43464 | Espacenet |
| JP 2024112982 A | 2024-08-21 | 4341 | O43464 | Espacenet |
| WO 2023162878 A | 2023-08-31 | 138 | O43464 | Espacenet |
1 to 10 of 56
See all 56 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,159
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HTRA2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA021765 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| R01NS101628 | Dendrite regulation by the mitochondrial kinase PINK1: Implications for PD/LBD | 3 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
| K12CA090628 | Paul Calabresi Program in Clinical/Translational Research at Mayo Clinic | 2 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 2 | 2025 |
| P30ES007033 | University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment | 2 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 2 | 2025 |
1 to 10 of 1,159Source NIH's project files
See all 1,159 nih grantsPapers2,128
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Benzamil-induced cytotoxicity in non-small cell lung cancer is associated with mitochondrial damage, mitochondrial elongation, and altered XIAP signaling. | J Pharmacol Sci | 2026 | 42810781 | PubTator, text mining | PubMed |
| Context-dependent roles of HtrA2/Omi in ovarian cancer: mitochondrial apoptotic function linking platinum sensitivity and acquired chemoresistance-a narrative review. | Transl Cancer Res | 2026 | 42724498 | PubTator, text mining | PubMed |
| Novel Clinical and Neurophysiological Insights in Neonatal-Onset 3-Methylglutaconic Aciduria Type VIII due to HTRA2 Mutations. | Mol Genet Genomic Med | 2026 | 42581774 | PubTator, text mining | PubMed |
| Host and Helicobacter pylori HtrA protease variants converge on Wnt/β-catenin signaling to drive stomach adenocarcinoma. | Gut Microbes | 2026 | 42493827 | PubTator, text mining | PubMed |
| Gene burden meta-analysis of 748 879 individuals identifies LGI1-ADAM23 protein complex association with epilepsy. | Epilepsia | 2026 | 42216960 | PubTator, text mining | PubMed |
| MASQ: A multiplex qPCR platform for quantitative alternative splicing analysis in clinical specimens. | Mol Ther Nucleic Acids | 2026 | 42023028 | PubTator, text mining | PubMed |
| Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications. | Signal Transduct Target Ther | 2026 | 41881983 | PubTator, text mining | PubMed |
| DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalk. | Front Cardiovasc Med | 2026 | 41798622 | PubTator, text mining | PubMed |
| Essential tremor: Family-based sequencing suggests involvement of neuronal and metabolic pathways. | Parkinsonism Relat Disord | 2026 | 41762786 | PubTator, text mining | PubMed |
| Erica spiculifolia Extract Potentiates Cisplatin Cytotoxicity by Reactivating p53 and Caspase-3-Dependent Apoptosis in Colorectal Carcinoma. | Molecules | 2026 | 41752487 | PubTator, text mining | PubMed |
1 to 10 of 2,128
See all 2,128 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/27429
GET https://conductscience.org/api/genes/v1/27429/patents?page=2