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EML4: EMAP like 4

1 protein, 16 patents, 6 drugs, 246 trials, 1,459 NIH grants and 4,982 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEML4HGNC
NameEMAP like 4HGNC
NCBI Gene ID27436NCBI Gene
HGNC IDHGNC:1316HGNC
EnsemblENSG00000143924NCBI Gene
AliasesC2orf2, ELP120, EMAP-4, EMAPL4, ROPP120NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9HC35Echinoderm microtubule-associated protein-like 49811Ensembl, GeneID, HGNCUniProt

Patents 16

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444661Q9HC35Espacenet
EP 4650780 A22025-11-195330Q9HC35Espacenet
EP 4640849 A22025-10-29751Q9HC35Espacenet
EP 4641201 A22025-10-294919Q9HC35Espacenet
JP 2025519096 A2025-06-24751Q9HC35Espacenet
JP 2025517969 A2025-06-124919Q9HC35Espacenet
JP 2025517970 A2025-06-125330Q9HC35Espacenet
US 11446398 B22022-09-2026542Q9HC35Espacenet
JP 2022524081 A2022-04-27129513Q9HC35Espacenet
JP 2022502411 A2022-01-115Q9HC35Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALECTINIBCHEMBL1738797EML4-ALK inhibitorINHIBITORChEMBL
ALECTINIB HYDROCHLORIDECHEMBL3707320EML4-ALK inhibitorINHIBITORChEMBL
CERITINIBCHEMBL2403108EML4-ALK inhibitorINHIBITORChEMBL
CRIZOTINIBCHEMBL601719EML4-ALK inhibitorINHIBITORChEMBL
LORLATINIBCHEMBL3286830EML4-ALK inhibitorINHIBITORChEMBL
PLB1003CHEMBL4650298EML4-ALK inhibitorINHIBITORChEMBL

Trials 246

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07573696ALECTINIBPHASE2ClinicalTrials.gov
NCT07567352LORLATINIBClinicalTrials.gov
NCT07560410ALECTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07560410CRIZOTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07556549LORLATINIBClinicalTrials.gov
NCT07415005LORLATINIBPHASE2ClinicalTrials.gov
NCT07207278ALECTINIBClinicalTrials.gov
NCT07207278CRIZOTINIBClinicalTrials.gov
NCT07083687LORLATINIBPHASE2ClinicalTrials.gov
NCT07001384ALECTINIBPHASE1ClinicalTrials.gov

NIH grants 1459

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1022,025NIH's project files
P30CA016672Cancer Center Support Grant662,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant352,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant222,025NIH's project files
R01CA164273Overcoming Resistance Mechanisms to Anaplastic Lymphoma Kinase Inhibitors212,025NIH's project files
P30CA068485Cancer Center Support Grant162,025NIH's project files
T32CA009207Investigational Cancer Therapeutics Training Program (ICTTP)142,025NIH's project files
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center102,025NIH's project files
K12CA086913Paul Calabresi Award in Clinical Oncology Research92,025NIH's project files
P30CA006973Regional Oncology Research Center92,025NIH's project files

Papers 4982

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42793623PubTator, text miningPubMed
42783151PubTator, text miningPubMed
42764588PubTator, text miningPubMed
42755602PubTator, text miningPubMed
42755474PubTator, text miningPubMed
42751117PubTator, text miningPubMed
42697737PubTator, text miningPubMed
42682602PubTator, text miningPubMed
42656778PubTator, text miningPubMed
42656487PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license