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GLS: glutaminase

1 protein, 39 patents, 1 drug, 22 trials, 3,933 NIH grants and 7,147 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGLSHGNC
NameglutaminaseHGNC
NCBI Gene ID2744NCBI Gene
HGNC IDHGNC:4331HGNC
EnsemblENSG00000115419NCBI Gene
AliasesAAD20, CASGID, DEE71, EIEE71, GAC, GAM, GDPAG, GLS1, KGA, KIAA0838NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O94925Glutaminase kidney isoform, mitochondrial66950Ensembl, GeneID, HGNCUniProt

Patents 39

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12653785 B22026-06-163O94925Espacenet
JP 2026004568 A2026-01-1447841O94925Espacenet
EP 4650780 A22025-11-195113O94925Espacenet
EP 4641201 A22025-10-294704O94925Espacenet
JP 2025147176 A2025-10-066043O94925Espacenet
JP 2025529142 A2025-09-046510O94925Espacenet
US 12371689 B22025-07-296510O94925Espacenet
JP 2025517969 A2025-06-124704O94925Espacenet
JP 2025517970 A2025-06-125113O94925Espacenet
JP 2025028160 A2025-02-286043O94925Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TELAGLENASTATCHEMBL3639788Glutaminase kidney isoform, mitochondrial inhibitorINHIBITORChEMBL

Trials 22

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07223528TELAGLENASTATPHASE1/PHASE2ClinicalTrials.gov
NCT05521997TELAGLENASTATPHASE2ClinicalTrials.gov
NCT04824937TELAGLENASTATPHASE2ClinicalTrials.gov
NCT04265534TELAGLENASTATPHASE2ClinicalTrials.gov
NCT04250545TELAGLENASTATPHASE1ClinicalTrials.gov
NCT03965845TELAGLENASTATPHASE1/PHASE2ClinicalTrials.gov
NCT03944902TELAGLENASTATPHASE1ClinicalTrials.gov
NCT03875313TELAGLENASTATPHASE1/PHASE22022-02-17ClinicalTrials.gov
NCT03872427TELAGLENASTATPHASE22025-07-01ClinicalTrials.gov
NCT03831932TELAGLENASTATPHASE1/PHASE22025-06-19ClinicalTrials.gov

NIH grants 3933

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant462,025NIH's project files
P30CA008748Cancer Center Support Grant452,025NIH's project files
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant202,025NIH's project files
R01CA051497Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis182,025NIH's project files
P30MH075673JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN)162,025NIH's project files
P30CA006973Regional Oncology Research Center152,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program132,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant132,025NIH's project files
P01CA117969Genetics and Biology of Pancreatic Ductal Adenocarcinoma112,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes112,025NIH's project files

Papers 7147

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826203PubTator, text miningPubMed
42825516PubTator, text miningPubMed
42819310PubTator, text miningPubMed
42809776PubTator, text miningPubMed
42804896PubTator, text miningPubMed
42793065PubTator, text miningPubMed
42783738PubTator, text miningPubMed
42776318PubTator, text miningPubMed
42776031PubTator, text miningPubMed
42767176PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license