Gene · 2745
GLRX: glutaredoxin
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GLRX: glutaredoxin. Genes, record 2745. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2745
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P35754 | Glutaredoxin-1 | 106 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents109
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47858 | P35754 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47859 | P35754 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47860 | P35754 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47861 | P35754 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 47862 | P35754 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 952 | P35754 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 952 | P35754 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 35263 | P35754 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 35264 | P35754 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 35265 | P35754 | Espacenet |
1 to 10 of 109
See all 109 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,834
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GLRX papers | Newest fiscal year |
|---|---|---|---|
| P30CA086862 | Cancer Center Support Grant | 7 | 2025 |
| P30ES001247 | Environmental Agents as Modulators of Disease Processes | 7 | 2025 |
| R01GM102187 | Chemical Tools for Probing Cysteine Sulfenation and Sulfination Redox Biology | 7 | 2025 |
| P20GM103449 | Vermont Biomedical Research Network-Vermont INBRE | 6 | 2025 |
| R01ES007331 | Mechanisms of Methylmercury Induced Neuronal Toxicity | 6 | 2025 |
| P01AG026572 | Perimenopause in Brain Aging and Alzheimer's Disease | 5 | 2025 |
| P30CA012197 | Cancer Center Support Grant | 5 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 5 | 2025 |
| T32ES007126 | Pre- and Postdoctoral Training in Toxicology | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,834Source NIH's project files
See all 1,834 nih grantsPapers3,142
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Disulphide maintenance systems and proteostasis. | Philos Trans R Soc Lond B Biol Sci | 2026 | 42817624 | PubTator, text mining | PubMed |
Pramipexole enhances levodopa's therapeutic efficacy in Parkinson's disease: Role of glutaredoxin-1 (GRX1), peroxiredoxin3 (PRX3), thioredoxin (TRX), 8-hydroxy-2 -deoxyguanosine (8-OHDG), and neurosteroid dehydroepiandrosterone sulfate (DHEA-S). | J Med Biochem | 2026 | 42775310 | PubTator, text mining | PubMed |
| RETRACTION: The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein. | Neurol Res Int | 2026 | 42756130 | PubTator, text mining | PubMed |
| Use of Neuronal-Enriched Extracellular Vesicles to Distinguish Cognitive Impairment Levels and Sex Differences in People with HIV. | Cells | 2026 | 42738875 | PubTator, text mining | PubMed |
| GRX2-Mediated Deglutathionylation of SIRT3 Alleviates Intestinal Ischemia/Reperfusion-Induced Mitochondrial Oxidative Damage. | Antioxid Redox Signal | 2026 | 42575846 | PubTator, text mining | PubMed |
| Se-methylselenocysteine induces NRF2-ATF4 stress signaling and ferroptosis-associated remodeling in pancreatic cancer. | Free Radic Biol Med | 2026 | 42551763 | PubTator, text mining | PubMed |
| Characterization of posttranslational modification in metabolic dysfunction-associated steatohepatitis: acetylation, lactylation, and phosphorylation. | J Lipid Res | 2026 | 42537908 | PubTator, text mining | PubMed |
| Paradoxical enhancement of oxidative stress-induced DNA damage and impaired redox homeostasis by Glutaredoxin 1 overexpression in human HeLa cells. | J Radiat Res | 2026 | 42520242 | PubTator, text mining | PubMed |
| SMCP maintains ROS homeostasis during sperm mitochondrial sheath assembly. | Reproduction | 2026 | 42484144 | PubTator, text mining | PubMed |
Deciphering the role of human thiol systems (Trx/Grx) in the transcriptional regulation: An emphasis on the role of thiol enzymes with the multifunctional APE1/Ref-1 enzyme in human health and diseases. | Biochem Biophys Res Commun | 2026 | 42476069 | PubTator, text mining | PubMed |
1 to 10 of 3,142
See all 3,142 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2745
GET https://conductscience.org/api/genes/v1/2745/patents?page=2