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Gene · 2745

GLRX: glutaredoxin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GLRX: glutaredoxin. Genes, record 2745. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2745

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Gene

Symbol
GLRX
HGNC
Name
glutaredoxin
HGNC
NCBI Gene ID
2745
NCBI Gene
HGNC ID
HGNC:4330
HGNC
Ensembl
ENSG00000173221
NCBI Gene
Aliases
GRX, GRX1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35754Glutaredoxin-11063Ensembl, GeneID, HGNC

Source UniProt

Patents109

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447858P35754Espacenet
JP 2026004568 A2026-01-1447859P35754Espacenet
JP 2026004568 A2026-01-1447860P35754Espacenet
JP 2026004568 A2026-01-1447861P35754Espacenet
JP 2026004568 A2026-01-1447862P35754Espacenet
EP 4650780 A22025-11-19952P35754Espacenet
JP 2025517970 A2025-06-12952P35754Espacenet
US 11446398 B22022-09-2035263P35754Espacenet
US 11446398 B22022-09-2035264P35754Espacenet
US 11446398 B22022-09-2035265P35754Espacenet

1 to 10 of 109

See all 109 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,834

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGLRX papersNewest fiscal year
P30CA086862Cancer Center Support Grant72025
P30ES001247Environmental Agents as Modulators of Disease Processes72025
R01GM102187Chemical Tools for Probing Cysteine Sulfenation and Sulfination Redox Biology72025
P20GM103449Vermont Biomedical Research Network-Vermont INBRE62025
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity62025
P01AG026572Perimenopause in Brain Aging and Alzheimer's Disease52025
P30CA012197Cancer Center Support Grant52025
P40OD010440Caenorhabditis Genetics Center52025
T32ES007126Pre- and Postdoctoral Training in Toxicology52025
P30CA008748Cancer Center Support Grant42025

1 to 10 of 1,834Source NIH's project files

See all 1,834 nih grants

Papers3,142

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Disulphide maintenance systems and proteostasis.Philos Trans R Soc Lond B Biol Sci202642817624PubTator, text miningPubMed
Pramipexole enhances levodopa's therapeutic efficacy in Parkinson's disease: Role of glutaredoxin-1 (GRX1), peroxiredoxin3 (PRX3), thioredoxin (TRX), 8-hydroxy-2 -deoxyguanosine (8-OHDG), and neurosteroid dehydroepiandrosterone sulfate (DHEA-S).
J Med Biochem202642775310PubTator, text miningPubMed
RETRACTION: The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein.Neurol Res Int202642756130PubTator, text miningPubMed
Use of Neuronal-Enriched Extracellular Vesicles to Distinguish Cognitive Impairment Levels and Sex Differences in People with HIV.Cells202642738875PubTator, text miningPubMed
GRX2-Mediated Deglutathionylation of SIRT3 Alleviates Intestinal Ischemia/Reperfusion-Induced Mitochondrial Oxidative Damage.Antioxid Redox Signal202642575846PubTator, text miningPubMed
Se-methylselenocysteine induces NRF2-ATF4 stress signaling and ferroptosis-associated remodeling in pancreatic cancer.Free Radic Biol Med202642551763PubTator, text miningPubMed
Characterization of posttranslational modification in metabolic dysfunction-associated steatohepatitis: acetylation, lactylation, and phosphorylation.J Lipid Res202642537908PubTator, text miningPubMed
Paradoxical enhancement of oxidative stress-induced DNA damage and impaired redox homeostasis by Glutaredoxin 1 overexpression in human HeLa cells.J Radiat Res202642520242PubTator, text miningPubMed
SMCP maintains ROS homeostasis during sperm mitochondrial sheath assembly.Reproduction202642484144PubTator, text miningPubMed
Deciphering the role of human thiol systems (Trx/Grx) in the transcriptional regulation: An emphasis on the role of thiol enzymes with the multifunctional APE1/Ref-1 enzyme in human health and diseases.
Biochem Biophys Res Commun202642476069PubTator, text miningPubMed

1 to 10 of 3,142

See all 3,142 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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