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Gene · 2775

GNAO1: G protein subunit alpha o1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GNAO1: G protein subunit alpha o1. Genes, record 2775. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2775

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Gene

Symbol
GNAO1
HGNC
Name
G protein subunit alpha o1
HGNC
NCBI Gene ID
2775
NCBI Gene
HGNC ID
HGNC:4389
HGNC
Ensembl
ENSG00000087258
NCBI Gene
Aliases
DEE17, EIEE17, G-ALPHA-o, GNAO, HG1G, NEDIM
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P09471Guanine nucleotide-binding protein G(o) subunit alpha35486Ensembl, GeneID, HGNC

Source UniProt

Patents41

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026053553 A2026-03-25149P09471Espacenet
JP 2026004568 A2026-01-1448443P09471Espacenet
EP 4641201 A22025-10-291644P09471Espacenet
JP 2025517969 A2025-06-121644P09471Espacenet
JP 2025032204 A2025-03-1129129P09471Espacenet
JP 2025032204 A2025-03-1129131P09471Espacenet
EP 4516806 A22025-03-05149P09471Espacenet
EP 4461818 A22024-11-1329129P09471Espacenet
EP 4461818 A22024-11-1329131P09471Espacenet
JP 2024069247 A2024-05-21149P09471Espacenet

1 to 10 of 41

See all 41 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,226

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGNAO1 papersNewest fiscal year
R01DA036596Regulation of Neuronal GPCR Signaling152025
P40OD010440Caenorhabditis Genetics Center82025
R01EY018139Molecular Organization of the First Visual Synapse62025
P30CA086862Cancer Center Support Grant52025
R01MH054137Structure and Function of Dopamine Receptors52025
P30EY001583P30 Core Grant For Vision Research42025
R35GM127303Understanding and Manipulating G Protein α Subunit and Phospholipase C Signaling Networks42025
P30ES005605Environmental Health Sciences Research Center32025
R35GM118105Negative and positive feedback in cell signaling32025
T32AA007565Multidisciplinary Training in the Biology of Alcohol Addiction32025

1 to 10 of 1,226Source NIH's project files

See all 1,226 nih grants

Papers1,584

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Benign Pneumoperitoneum: A Case Report and Literature Review.Cureus202642774634PubTator, text miningPubMed
Case Report: Early infantile drug-resistant epilepsy and gastrointestinal dysmotility associated with a de novo GNAO1 variant and a 16p13.11 microdeletion.Front Pediatr202642729318PubTator, text miningPubMed
Novel and Emerging Therapies for Childhood-Onset Movement Disorders.Mov Disord202642723627PubTator, text miningPubMed
Diagnostic delay in infants with very early-onset rare and ultra-rare genetic epilepsies.Dev Med Child Neurol202642573089PubTator, text miningPubMed
Safety and feasibility of oral zinc for patients with GNAO1-related disorders (ZINCGNAO1): an open-label, single-arm, single-centre, pilot trial in Germany.EClinicalMedicine202642542632PubTator, text miningPubMed
G-protein coupled receptor, signal and signal-transduction related transcript mapping in nigral volume and pigmented neurons reveals a potential deficit of nigral feedback signals associated with Parkinson's disease.
PLoS One202642497285PubTator, text miningPubMed
Innovative Three-dimensional-printed Appliance for the Management of Neuropathologic Chewing in a Child.Contemp Clin Dent202642428293PubTator, text miningPubMed
A Novel GNAO1 Variant Associated With Variable and Mild Phenotypes in a Spanish Family.J Mov Disord202642403284PubTator, text miningPubMed
Gnao1 acts as a gatekeeper to alleviate neuropathic pain by silencing pro-nociceptive signaling cascades.J Headache Pain202642337441PubTator, text miningPubMed
Exome sequencing of pashtun familial epilepsy in Pakistan reveals novel variants in LAMA5, KCNQ2 and GNAO1.Mol Biol Rep202642313205PubTator, text miningPubMed

1 to 10 of 1,584

See all 1,584 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2775

GET https://conductscience.org/api/genes/v1/2775/patents?page=2