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Gene · 2798

GNRHR: gonadotropin releasing hormone receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GNRHR: gonadotropin releasing hormone receptor. Genes, record 2798. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2798

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Gene

Symbol
GNRHR
HGNC
Name
gonadotropin releasing hormone receptor
HGNC
NCBI Gene ID
2798
NCBI Gene
HGNC ID
HGNC:4421
HGNC
Ensembl
ENSG00000109163
NCBI Gene
Aliases
GNRHR1, GRHR, HH7, LHRHR, LRHR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30968Gonadotropin-releasing hormone receptor3281Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448183P30968Espacenet
EP 4641201 A22025-10-29465P30968Espacenet
JP 2025529142 A2025-09-041747P30968Espacenet
US 12371689 B22025-07-291747P30968Espacenet
JP 2025517969 A2025-06-12465P30968Espacenet
US 11446398 B22022-09-2036085P30968Espacenet
US 11400116 B22022-08-02119P30968Espacenet
JP 2022524081 A2022-04-27139056P30968Espacenet
US 11078247 B22021-08-034572P30968Espacenet
US 11066693 B22021-07-202P30968Espacenet

1 to 10 of 36

See all 36 patents

Drugs33

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABARELIXCHEMBL1252Gonadotropin-releasing hormone receptor antagonistANTAGONISTChEMBL
ACYLINECHEMBL262747Gonadotropin-releasing hormone receptor antagonistANTAGONISTChEMBL
BUSERELINCHEMBL2110824Gonadotropin-releasing hormone receptor agonistAGONISTChEMBL
CETRORELIXCHEMBL1200490Gonadotropin-releasing hormone receptor antagonistANTAGONISTChEMBL
CETRORELIX ACETATECHEMBL2103735Gonadotropin-releasing hormone receptor antagonistANTAGONISTChEMBL
DEGARELIXCHEMBL415606Gonadotropin-releasing hormone receptor antagonistANTAGONISTChEMBL
DEGARELIX ACETATECHEMBL2028987Gonadotropin-releasing hormone receptor antagonistANTAGONISTChEMBL
ELAGOLIXCHEMBL1208155Gonadotropin-releasing hormone receptor antagonistANTAGONISTChEMBL
ELAGOLIX SODIUMCHEMBL502182Gonadotropin-releasing hormone receptor antagonistANTAGONISTChEMBL
GANIRELIXCHEMBL1251Gonadotropin-releasing hormone receptor antagonistANTAGONISTChEMBL

1 to 10 of 33

See all 33 drugs

Trials1,042

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07569315GONADORELINPHASE2ClinicalTrials.gov
NCT07569315GONADORELIN ACETATEPHASE2ClinicalTrials.gov
NCT07460752GOSERELIN ACETATEPHASE2ClinicalTrials.gov
NCT07455903LEUPROLIDEPHASE2ClinicalTrials.gov
NCT07455903TRIPTORELINPHASE2ClinicalTrials.gov
NCT07455903RELUGOLIXPHASE2ClinicalTrials.gov
NCT07455903DEGARELIXPHASE2ClinicalTrials.gov
NCT07444983LEUPROLIDEClinicalTrials.gov
NCT07409493GANIRELIXClinicalTrials.gov
NCT07394530GONADORELINClinicalTrials.gov

1 to 10 of 1,042

See all 1,042 trials

NIH grants1,057

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGNRHR papersNewest fiscal year
R01DK046943Integrated systems biology of the pituitary122025
P51OD011092Support for National Primate Research Center82025
T32HD007203Training in Reproductive Sciences82025
ZIAHD000195Intracellular Signaling In Endocrine Cells72025
P30CA008748Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant52025
P30DK063491Diabetes Research Center (DRC)52025
R01DK043140Mechanisms Leading to Adrenal Zonation52025
R01HD082314Deciphering the functional role of MKRN3 in puberty and reproduction52025
T32DK007028Training Program in Endocrinology52025

1 to 10 of 1,057Source NIH's project files

See all 1,057 nih grants

Papers2,995

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Achieving Minimal-to-No Pain in Women with Endometriosis Treated with Relugolix Combination Therapy: SPIRIT Extension Trial.Int J Womens Health202642719373PubTator, text miningPubMed
NMR Structural Elucidation of Mitoxantrone-Gonadotropin-Releasing Hormone (GnRH) Conjugates Implicated in Hormone-Dependent Cancer.Int J Mol Sci202642653438PubTator, text miningPubMed
Investigation of Adverse Events Associated with Predicted GnRHR Agonists Using the FAERS Database.Int J Mol Sci202642589332PubTator, text miningPubMed
Post-COVID-19 rise in central precocious puberty: an integrative Review.J Pediatr Endocrinol Metab202642515816PubTator, text miningPubMed
Whole-Genome Resequencing-Based Selection-Signal and Association Analyses Prioritize Candidate Genes and Haplotypes for PRRS Resistance-Related Traits in Pigs.Animals (Basel)202642511095PubTator, text miningPubMed
Developmental lead exposure fractures the hypothalamic-pituitary-gonadal axis in dams: mechanistic insights into primary ovarian failure and central bioenergetic bottlenecks.Naunyn Schmiedebergs Arch Pharmacol202642461322PubTator, text miningPubMed
Understanding GnRH: local systems, signalling mechanisms and implications in female health.Open Biol202642379585PubTator, text miningPubMed
Reversible congenital hypogonadotropic hypogonadism: keys for clinical management.Arch Endocrinol Metab202642348776PubTator, text miningPubMed
Multi-trait GWAS of reaction norm parameters reveals environment-responsive loci influencing reproductive performance in heifers.J Anim Sci Biotechnol202642252397PubTator, text miningPubMed
Roles of Goserelin in Gynecological Disorders.Drug Des Devel Ther202642226753PubTator, text miningPubMed

1 to 10 of 2,995

See all 2,995 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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