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Gene · 2805

GOT1: glutamic-oxaloacetic transaminase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GOT1: glutamic-oxaloacetic transaminase 1. Genes, record 2805. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2805

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Gene

Symbol
GOT1
HGNC
Name
glutamic-oxaloacetic transaminase 1
HGNC
NCBI Gene ID
2805
NCBI Gene
HGNC ID
HGNC:4432
HGNC
Ensembl
ENSG00000120053
NCBI Gene
Aliases
AST, AST1, ASTQTL1, GIG18, SGOT, cAspAT, cCAT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17174Aspartate aminotransferase, cytoplasmic4137Ensembl, GeneID, HGNC

Source UniProt

Patents70

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4820392 A12026-10-1483P17174Espacenet
JP 2026004568 A2026-01-1447833P17174Espacenet
EP 4650780 A22025-11-198789P17174Espacenet
EP 4641201 A22025-10-298998P17174Espacenet
JP 2025517969 A2025-06-128998P17174Espacenet
JP 2025517970 A2025-06-128789P17174Espacenet
JP 2025032204 A2025-03-1129170P17174Espacenet
JP 2024545363 A2024-12-0513P17174Espacenet
EP 4461818 A22024-11-1329170P17174Espacenet
KR 1020240103006 A2024-07-0313P17174Espacenet

1 to 10 of 70

See all 70 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,179

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGOT1 papersNewest fiscal year
P01CA117969Genetics and Biology of Pancreatic Ductal Adenocarcinoma152025
R37CA237421Intratumoral Metabolic Crosstalk Promotes Therapeutic Resistance in Pancreatic Cancer152025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028122025
P30CA008748Cancer Center Support Grant112025
P30CA016087Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant72025
P30CA030199Cancer Center Support Grant (CCSG)62025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes52025
P30CA010815Consolidated Basic Cancer Research Program42025
P30CA043703Case Comprehensive Cancer Center Support Grant42025

1 to 10 of 1,179Source NIH's project files

See all 1,179 nih grants

Papers1,629

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Profiling proteomic responses in small intestinal neuroendocrine tumor GOT1 after [177Lu]Lu-DOTATATE therapy.BMC Cancer202642754856PubTator, text miningPubMed
Integrated multi-omics analysis of metabolomics and proteomics uncovers dysregulated amino acid metabolism in HCC metastasis.Front Immunol202642688489PubTator, text miningPubMed
Identification of GOT1, OAF, XPNPEP2, CRISPLD2, and RPS21 as Sorafenib-Treatment-Associated Candidate Biomarkers for Hepatocellular Carcinoma.Curr Med Chem202642634552PubTator, text miningPubMed
Glutamine-restricted diets restore sensitivity to KRASG12D inhibitor through the reversal of ANXA1 mediated metabolic reprogramming.Cell Rep Med202642561948PubTator, text miningPubMed
Lifestyle and psychosocial protective factors drive healthy aging and modulate inflammatory and metabolic pathways.Geroscience202642554773PubTator, text miningPubMed
CircTAF15 (hsa_circ_0043138) promotes NSCLC progression through stabilizing YBX1 to initiate GOT1 transcription.Int J Biol Macromol202642425339PubTator, text miningPubMed
Hypoxia-preconditioned dental pulp stem cells alleviate acetaminophen-induced liver failure via promoting MYC-HIF1A/HIF-1α-BNIP3-mediated mitophagy.Autophagy202642402967PubTator, text miningPubMed
Effect of topical phenylephrine on aqueous flare levels and anterior scleral thickness in healthy adult eyes.BMC Ophthalmol202642316074PubTator, text miningPubMed
H3K18la- driven neutrophil secretory autophagy promotes pulmonary endothelial dysfunction in sepsis-induced lung injury.Autophagy202642283498PubTator, text miningPubMed
Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts.Cell Rep202642276069PubTator, text miningPubMed

1 to 10 of 1,629

See all 1,629 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2805

GET https://conductscience.org/api/genes/v1/2805/patents?page=2