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Gene · 2820

GPD2: glycerol-3-phosphate dehydrogenase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GPD2: glycerol-3-phosphate dehydrogenase 2. Genes, record 2820. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2820

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Gene

Symbol
GPD2
HGNC
Name
glycerol-3-phosphate dehydrogenase 2
HGNC
NCBI Gene ID
2820
NCBI Gene
HGNC ID
HGNC:4456
HGNC
Ensembl
ENSG00000115159
NCBI Gene
Aliases
GDH2, GPDM, mGDH, mGPDH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P43304Glycerol-3-phosphate dehydrogenase, mitochondrial7270Ensembl, GeneID, HGNC

Source UniProt

Patents92

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194568P43304Espacenet
EP 4641201 A22025-10-2912995P43304Espacenet
EP 4641201 A22025-10-294120P43304Espacenet
JP 2025147176 A2025-10-066129P43304Espacenet
JP 2025147176 A2025-10-066130P43304Espacenet
JP 2025147176 A2025-10-066131P43304Espacenet
JP 2025147176 A2025-10-066132P43304Espacenet
JP 2025529142 A2025-09-046529P43304Espacenet
US 12371689 B22025-07-296529P43304Espacenet
JP 2025517969 A2025-06-124120P43304Espacenet

1 to 10 of 92

See all 92 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
METFORMINCHEMBL1431Mitochondrial glycerol-3-phosphate dehydrogenase inhibitorINHIBITORChEMBL
METFORMIN HYDROCHLORIDECHEMBL1703Mitochondrial glycerol-3-phosphate dehydrogenase inhibitorINHIBITORChEMBL

Trials1,214

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants741

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGPD2 papersNewest fiscal year
P30DK045735Yale Diabetes Research Center62025
P30CA016672Cancer Center Support Grant42025
P42ES004911Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands42025
P30DK036836Diabetes Research Center32025
UL1TR001863Yale Clinical and Translational Science Award32025
P30CA008748Cancer Center Support Grant22025
P30CA016056Roswell Park Cancer Center Support Grant22025
P30DK034989Yale Liver Center22025
P30ES006694Southwest Environmental Health Sciences Center22025
P50AA011999Southern California Research Center for ALPD and Cirrhosis22025

1 to 10 of 741Source NIH's project files

See all 741 nih grants

Papers740

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-omics analyses prioritize potential biomarkers and drug targets for obstructive sleep apnea.Sleep202642821293PubTator, text miningPubMed
Integrating multi-omics and machine learning to predict microplastic cytotoxicity under leave-one-polymer-out validation.Environ Pollut202642785618PubTator, text miningPubMed
Repurposed metformin-apigenin combination therapy for metabolic dysfunction-associated steatohepatitis: from integrative multi-omics discovery to in vivo validation.Front Pharmacol202642761201PubTator, text miningPubMed
Near-Infrared Imaging of Senescence-Associated β-Galactosidase Enables Discovery of a Glycerol-3-Phosphate Dehydrogenase 2-Regulated Neuroprotective Pathway in Alzheimer's Disease.ACS Sens202642676148PubTator, text miningPubMed
Causal links between diabetes, gut microbiota, and colon cancer: insights from Mendelian randomization.Endokrynol Pol202642200339PubTator, text miningPubMed
Multi-omics Mendelian randomization identifies mitochondrial genes associated with immune microenvironment signatures in endometriosis.Front Reprod Health202642157969PubTator, text miningPubMed
Glycerol enhances mitochondrial metabolism and inflammatory response in pro-inflammatory macrophages.EMBO Rep202641981083PubTator, text miningPubMed
A Novel Wogonin Derivative Induces Apoptosis in PC-3M Cells by Targeting Mitochondrial Dysfunction and Activating the ROS-p38/MAPK Pathway.Molecules202641828845PubTator, text miningPubMed
Tissue Iron Predicts Metformin Responsiveness in a Mouse Model and in Humans with Type 2 Diabetes.Diabetes Metab Syndr Obes202641808963PubTator, text miningPubMed
Disruption of neutrophil homeostasis is associated with functional alterations in mitochondria of critically ill COVID-19 patients.Sci Rep202641764210PubTator, text miningPubMed

1 to 10 of 740

See all 740 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2820

GET https://conductscience.org/api/genes/v1/2820/patents?page=2