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Gene · 282616

IFNL2: interferon lambda 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IFNL2: interferon lambda 2. Genes, record 282616. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/282616

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Gene

Symbol
IFNL2
HGNC
Name
interferon lambda 2
HGNC
NCBI Gene ID
282616
NCBI Gene
HGNC ID
HGNC:18364
HGNC
Ensembl
ENSG00000183709
NCBI Gene
Aliases
IFNL2a, IFNL3a, IL-28A, IL28A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8IZJ0Interferon lambda-22000Ensembl, GeneID, HGNC

Source UniProt

Patents135

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12534732 B22026-01-27914Q8IZJ0Espacenet
JP 2026012378 A2026-01-23914Q8IZJ0Espacenet
US 12516329 B22026-01-06914Q8IZJ0Espacenet
EP 4670792 A22025-12-31914Q8IZJ0Espacenet
EP 4650780 A22025-11-196032Q8IZJ0Espacenet
KR 1020250160362 A2025-11-12914Q8IZJ0Espacenet
JP 2025147176 A2025-10-066757Q8IZJ0Espacenet
JP 2025529142 A2025-09-046664Q8IZJ0Espacenet
JP 2025524620 A2025-07-30373Q8IZJ0Espacenet
US 12371689 B22025-07-296664Q8IZJ0Espacenet

1 to 10 of 135

See all 135 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,310

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIFNL2 papersNewest fiscal year
P30DK034854Integrated Epithelial and Muscosal Biology92025
P30CA047904Cancer Center Support Grant82025
R01AI121066Innate control of the inflammatory process during fungal infections72025
R01DK115217Type III interferon Control of Mucosal Immunity72025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success72025
U19AI095227Viral and Host Determinants of Infant and Childhood Allergy and Asthma52025
P30AI094189The Johns Hopkins Center for AIDS Research (JHU CFAR)42025
P30CA016672Cancer Center Support Grant42025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease42025
R01AR071384Characterization of interferon kappa as a novel target in cutaneous lupus42025

1 to 10 of 1,310Source NIH's project files

See all 1,310 nih grants

Papers1,810

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Differential host responses by the type I and III interferons in primary differentiated human nasal epithelial cells are a determinant of antiviral activity.Front Pharmacol202642812250PubTator, text miningPubMed
Perioperative Inflammatory Cytokine Profiles in Patients with Atrial Fibrillation Undergoing Catheter Treatment: A Prospective Observational Study from Kazakhstan.J Clin Med202642452724PubTator, text miningPubMed
Interferon lambda in anti-viral defense and cancer: dual roles, mechanism and therapeutic potential.J Transl Med202642092929PubTator, text miningPubMed
Refining biomarker-based clustering of cardiovascular inflammatory phenotypes in HIV using Recursive Feature Addition: A comparative evaluation approach.PLoS Comput Biol202642044089PubTator, text miningPubMed
Imbalance of type I and II interferon pathways is associated with pain perception in Sjogren's disease: a real-life study.Front Immunol202642039197PubTator, text miningPubMed
Interferon dynamics in deltaretroviruses: why HTLV-1 evades, but BLV responds.Mol Biol Rep202641920397PubTator, text miningPubMed
Monkeypox virus replication and host response in vaginal and ectocervical epithelial cells.Virulence202641880196PubTator, text miningPubMed
A genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication.Nat Commun202641826287PubTator, text miningPubMed
MERS-CoV and SARS-CoV-1 proteins inhibit the IFN-α JAK/STAT pathway of epithelial cells, via IFN-λ-induced USP18.Front Immunol202641798916PubTator, text miningPubMed
Differential antiviral effects and immune responses in nasal and airway organoid during RSV infection: implications for interferon therapy.Front Immunol202641789060PubTator, text miningPubMed

1 to 10 of 1,810

See all 1,810 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/282616

GET https://conductscience.org/api/genes/v1/282616/patents?page=2