Gene · 284217
LAMA1: laminin subunit alpha 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LAMA1: laminin subunit alpha 1. Genes, record 284217. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/284217
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P25391 | Laminin subunit alpha-1 | 3,075 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents67
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 271 | P25391 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 51081 | P25391 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 10698 | P25391 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1640 | P25391 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 11112 | P25391 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 7642 | P25391 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6849 | P25391 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6849 | P25391 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1640 | P25391 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 11112 | P25391 | Espacenet |
1 to 10 of 67
See all 67 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| OCRIPLASMIN | CHEMBL2095222 | Laminin hydrolytic enzyme | HYDROLYTIC ENZYME |
Source ChEMBL
Trials10
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02747030 | OCRIPLASMIN | PHASE1 | ClinicalTrials.gov | |
| NCT02681809 | OCRIPLASMIN | PHASE2 | 2020-12-16 | ClinicalTrials.gov |
| NCT01429441 | OCRIPLASMIN | PHASE3 | 2016-01-11 | ClinicalTrials.gov |
| NCT00996684 | OCRIPLASMIN | PHASE2 | ClinicalTrials.gov | |
| NCT00798317 | OCRIPLASMIN | PHASE3 | 2013-01-30 | ClinicalTrials.gov |
| NCT00781859 | OCRIPLASMIN | PHASE3 | 2013-01-28 | ClinicalTrials.gov |
| NCT00428129 | OCRIPLASMIN | PHASE2 | ClinicalTrials.gov | |
| NCT00412451 | OCRIPLASMIN | PHASE2 | 2013-09-13 | ClinicalTrials.gov |
| NCT00123305 | OCRIPLASMIN | PHASE2 | ClinicalTrials.gov | |
| NCT00123266 | OCRIPLASMIN | PHASE2 | ClinicalTrials.gov |
NIH grants1,005
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LAMA1 papers | Newest fiscal year |
|---|---|---|---|
| P20GM103446 | Delaware INBRE | 5 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 3 | 2025 |
| R01DC014461 | A Hydrogel-Based Cellular Model of the Human Vocal Fold | 3 | 2025 |
| R01DE029655 | Bottom-Up Assembly of Functional Salivary Gland Tissues | 3 | 2025 |
| R01EY012200 | Pax6 as a key regulator of lens development | 3 | 2025 |
| U54GM104940 | Louisiana Clinical and Translational Science Center | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 2 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 1,005Source NIH's project files
See all 1,005 nih grantsPapers1,367
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Whole-exome sequencing identifies matrisomal gene associations in monogenic cerebral small vessel disease. | J Neurol | 2026 | 42481886 | PubTator, text mining | PubMed |
| Hereditary spastic paraplegia in three siblings with distinct genetic mutations. | J Int Med Res | 2026 | 42446524 | PubTator, text mining | PubMed |
| Fostering cell-cell interactions and integrating angiocrine factors to promote the development of salivary microtissues in 3D. | Bioeng Transl Med | 2026 | 42272969 | PubTator, text mining | PubMed |
| Prenatal Diagnosis of Poretti-Boltshauser Syndrome: A Case of Live Birth with Confirmed LAMA1 Variants. | Cerebellum | 2026 | 42105148 | PubTator, text mining | PubMed |
| Novel LAMA1 Mutations in a Pedigree With Poretti-Boltshauser Syndrome: Implications for Hypomyelination. | Mol Genet Genomic Med | 2026 | 42043906 | PubTator, text mining | PubMed |
| Gene Expression Alterations Associated With Resveratrol-Induced Antiproliferative Effects and S-Phase Cell Cycle Arrest in Osteosarcoma Cancer Cells. | J Cell Mol Med | 2026 | 41937498 | PubTator, text mining | PubMed |
| Targeted proteomic and bioinformatic investigation of extracellular matrix remodeling in hAEC-EV-mediated corneal repair. | Front Bioeng Biotechnol | 2026 | 41929428 | PubTator, text mining | PubMed |
| Proteome Profiling Reveals Inflammation and Fibrosis Biomarkers in Urinary Migrasomes of Patients with Diabetic Kidney Disease. | J Proteome Res | 2026 | 41906798 | PubTator, text mining | PubMed |
| Multi-omics and causal inference reveal lactylation-based osteoblast regulatory networks and drug candidates. | iScience | 2026 | 41736870 | PubTator, text mining | PubMed |
| Small extracellular vesicles produced by homeostatic phenotype BMSC promote bone regeneration by transferring anti-senescent factor JMJD6. | J Nanobiotechnology | 2026 | 41723429 | PubTator, text mining | PubMed |
1 to 10 of 1,367
See all 1,367 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/284217
GET https://conductscience.org/api/genes/v1/284217/patents?page=2