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Gene · 284654

RSPO1: R-spondin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RSPO1: R-spondin 1. Genes, record 284654. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/284654

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Gene

Symbol
RSPO1
HGNC
Name
R-spondin 1
HGNC
NCBI Gene ID
284654
NCBI Gene
HGNC ID
HGNC:21679
HGNC
Ensembl
ENSG00000169218
NCBI Gene
Aliases
CRISTIN3, FLJ40906, RSPO, RSPONDIN
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q2MKA7R-spondin-126312Ensembl, GeneID, HGNC

Source UniProt

Patents144

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026034588 A2026-02-2710Q2MKA7Espacenet
JP 2026021430 A2026-02-104Q2MKA7Espacenet
JP 2026004467 A2026-01-1410Q2MKA7Espacenet
JP 2026004568 A2026-01-1462483Q2MKA7Espacenet
JP 2026004568 A2026-01-1462484Q2MKA7Espacenet
JP 2026004568 A2026-01-1462485Q2MKA7Espacenet
EP 4650780 A22025-11-197315Q2MKA7Espacenet
KR 1020250148592 A2025-10-141Q2MKA7Espacenet
JP 2025147176 A2025-10-0611569Q2MKA7Espacenet
JP 2025147176 A2025-10-0611570Q2MKA7Espacenet

1 to 10 of 144

See all 144 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,814

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRSPO1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant282025
P30CA045508CSHL Cancer Center Support Grant112025
P30DK034854Integrated Epithelial and Muscosal Biology102025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease102025
P01AI125181Pathogenesis of E. coli and Shigella infections in human enteroid models92025
P30DK056338Texas Medical Center Digestive Diseases Center92025
R24HD000836Laboratory of Developmental Biology82025
U19AI116484Stanford/UNC Biomimetic U19 Research Center82025
U19AI116497Human Biomimetics for Mucosal Infections82025
P01CA013106Targeting Transcription and Splicing in Cancer72025

1 to 10 of 1,814Source NIH's project files

See all 1,814 nih grants

Papers2,310

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Is Rspo1 a friend or foe in ESCC? Rethinking wnt signaling in tumor prognostics.Indian J Pathol Microbiol202642809732PubTator, text miningPubMed
RNF research trends and an RNF43-based prognostic model for colorectal cancer with immune microenvironment analysis.Discov Oncol202642671492PubTator, text miningPubMed
Neurovascular-Immune Biomarkers in Ménière Disease: Insights From High-Throughput Proteomics.Otol Neurotol202642584982PubTator, text miningPubMed
Comparative evaluation of chemotherapy and CAR-T cell therapy in genetically engineered self-sustaining primary pancreatic cancer organoids.Pancreatology202642532746PubTator, text miningPubMed
An empirically refined workflow for generating patient-derived organoids from epithelial ovarian cancer.Sci Rep202642477445PubTator, text miningPubMed
Spectrum of Cytogenetic and Molecular Abnormalities in Disorders of Sex Development: A Retrospective Observational Study From Western India.Cureus202642465163PubTator, text miningPubMed
Converging Signaling Networks Drive Taste Bud Morphogenesis, Turnover, and Regeneration.Int J Mol Sci202642449922PubTator, text miningPubMed
Clinicopathologic and Molecular Analysis of Traditional Serrated Adenoma and Its Possible Precursor Lesions With Special Reference to RSPO Fusion Status : A Large Case Series From Single Institution.Am J Surg Pathol202642393851PubTator, text miningPubMed
Developmental reproductive impacts of gestational polystyrene nanoplastics exposure: precocious puberty and impaired ovarian reserve in female offspring.Food Chem Toxicol202642379508PubTator, text miningPubMed
History of the decline and repositioning of the H-Y antigen: From sex determination to reproductive immunology.J Reprod Immunol202642263396PubTator, text miningPubMed

1 to 10 of 2,310

See all 2,310 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/284654

GET https://conductscience.org/api/genes/v1/284654/patents?page=2