Gene · 284654
RSPO1: R-spondin 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RSPO1: R-spondin 1. Genes, record 284654. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/284654
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q2MKA7 | R-spondin-1 | 263 | 12 | Ensembl, GeneID, HGNC |
Source UniProt
Patents144
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026034588 A | 2026-02-27 | 10 | Q2MKA7 | Espacenet |
| JP 2026021430 A | 2026-02-10 | 4 | Q2MKA7 | Espacenet |
| JP 2026004467 A | 2026-01-14 | 10 | Q2MKA7 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 62483 | Q2MKA7 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 62484 | Q2MKA7 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 62485 | Q2MKA7 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7315 | Q2MKA7 | Espacenet |
| KR 1020250148592 A | 2025-10-14 | 1 | Q2MKA7 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 11569 | Q2MKA7 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 11570 | Q2MKA7 | Espacenet |
1 to 10 of 144
See all 144 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,814
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RSPO1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 28 | 2025 |
| P30CA045508 | CSHL Cancer Center Support Grant | 11 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 10 | 2025 |
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 10 | 2025 |
| P01AI125181 | Pathogenesis of E. coli and Shigella infections in human enteroid models | 9 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 9 | 2025 |
| R24HD000836 | Laboratory of Developmental Biology | 8 | 2025 |
| U19AI116484 | Stanford/UNC Biomimetic U19 Research Center | 8 | 2025 |
| U19AI116497 | Human Biomimetics for Mucosal Infections | 8 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 7 | 2025 |
1 to 10 of 1,814Source NIH's project files
See all 1,814 nih grantsPapers2,310
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Is Rspo1 a friend or foe in ESCC? Rethinking wnt signaling in tumor prognostics. | Indian J Pathol Microbiol | 2026 | 42809732 | PubTator, text mining | PubMed |
| RNF research trends and an RNF43-based prognostic model for colorectal cancer with immune microenvironment analysis. | Discov Oncol | 2026 | 42671492 | PubTator, text mining | PubMed |
| Neurovascular-Immune Biomarkers in Ménière Disease: Insights From High-Throughput Proteomics. | Otol Neurotol | 2026 | 42584982 | PubTator, text mining | PubMed |
| Comparative evaluation of chemotherapy and CAR-T cell therapy in genetically engineered self-sustaining primary pancreatic cancer organoids. | Pancreatology | 2026 | 42532746 | PubTator, text mining | PubMed |
| An empirically refined workflow for generating patient-derived organoids from epithelial ovarian cancer. | Sci Rep | 2026 | 42477445 | PubTator, text mining | PubMed |
| Spectrum of Cytogenetic and Molecular Abnormalities in Disorders of Sex Development: A Retrospective Observational Study From Western India. | Cureus | 2026 | 42465163 | PubTator, text mining | PubMed |
| Converging Signaling Networks Drive Taste Bud Morphogenesis, Turnover, and Regeneration. | Int J Mol Sci | 2026 | 42449922 | PubTator, text mining | PubMed |
| Clinicopathologic and Molecular Analysis of Traditional Serrated Adenoma and Its Possible Precursor Lesions With Special Reference to RSPO Fusion Status : A Large Case Series From Single Institution. | Am J Surg Pathol | 2026 | 42393851 | PubTator, text mining | PubMed |
| Developmental reproductive impacts of gestational polystyrene nanoplastics exposure: precocious puberty and impaired ovarian reserve in female offspring. | Food Chem Toxicol | 2026 | 42379508 | PubTator, text mining | PubMed |
| History of the decline and repositioning of the H-Y antigen: From sex determination to reproductive immunology. | J Reprod Immunol | 2026 | 42263396 | PubTator, text mining | PubMed |
1 to 10 of 2,310
See all 2,310 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/284654
GET https://conductscience.org/api/genes/v1/284654/patents?page=2