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ANGPT2: angiopoietin 2

1 protein, 292 patents, 8 drugs, 80 trials, 4,734 NIH grants and 11,580 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolANGPT2HGNC
Nameangiopoietin 2HGNC
NCBI Gene ID285NCBI Gene
HGNC IDHGNC:485HGNC
EnsemblENSG00000091879NCBI Gene
AliasesAGPT2, ANG2, Ang2, LMPHM10NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15123Angiopoietin-24967Ensembl, GeneID, HGNCUniProt

Patents 292

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12624098 B22026-05-1225O15123Espacenet
US 12522653 B22026-01-1327O15123Espacenet
EP 4650780 A22025-11-194981O15123Espacenet
EP 4641201 A22025-10-294563O15123Espacenet
WO 2025219504 A12025-10-2325O15123Espacenet
JP 2025147176 A2025-10-06804O15123Espacenet
JP 2025529142 A2025-09-045475O15123Espacenet
KR 1020250130525 A2025-09-0242O15123Espacenet
US 12398203 B22025-08-2631O15123Espacenet
JP 2025525442 A2025-08-0541O15123Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMG-780CHEMBL2109586Angiopoietin-2 inhibitorINHIBITORChEMBL
CVX-060CHEMBL4594470Angiopoietin-2 inhibitorINHIBITORChEMBL
FARICIMABCHEMBL4297750Angiopoietin-2 inhibitorINHIBITORChEMBL
MEDI-3617CHEMBL2109298Angiopoietin-2 inhibitorINHIBITORChEMBL
NESVACUMABCHEMBL2108678Angiopoietin-2 inhibitorINHIBITORChEMBL
TREBANANIBCHEMBL2108568Angiopoietin-2 inhibitorINHIBITORChEMBL
VANUCIZUMABCHEMBL3545259Angiopoietin-2 inhibitorINHIBITORChEMBL
ZANSECIMABCHEMBL4650486Angiopoietin-2 inhibitorINHIBITORChEMBL

Trials 80

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07526857FARICIMABClinicalTrials.gov
NCT07520045FARICIMABClinicalTrials.gov
NCT07484074FARICIMABPHASE1ClinicalTrials.gov
NCT07461441FARICIMABPHASE3ClinicalTrials.gov
NCT07425522FARICIMABPHASE1ClinicalTrials.gov
NCT07403825FARICIMABPHASE4ClinicalTrials.gov
NCT07249216FARICIMABClinicalTrials.gov
NCT07187804FARICIMABPHASE4ClinicalTrials.gov
NCT07144865FARICIMABClinicalTrials.gov
NCT07093385FARICIMABPHASE2ClinicalTrials.gov

NIH grants 4734

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant512,025NIH's project files
P30CA008748Cancer Center Support Grant322,025NIH's project files
P30CA006973Regional Oncology Research Center182,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award182,025NIH's project files
R01NS055349Severe Malaria And Risk to The Brain (SMART Brain)112,025NIH's project files
ZIAAI001083Studies in the Pathogenesis of Systemic Capillary Leak Syndrome112,025NIH's project files
U10CA180821Alliance for Clinical Trials in Oncology Operations Center - GY11 Funded Extension102,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support92,025NIH's project files
P50CA165962Targeted Therapies for Glioma92,025NIH's project files
U10CA180882Alliance Statistics and Data Management Center92,025NIH's project files

Papers 11580

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816624PubTator, text miningPubMed
42813914PubTator, text miningPubMed
42809553PubTator, text miningPubMed
42805085PubTator, text miningPubMed
42801171PubTator, text miningPubMed
42796720PubTator, text miningPubMed
42795729PubTator, text miningPubMed
42793172PubTator, text miningPubMed
42787653PubTator, text miningPubMed
42787257PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license