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Gene · 285242

HTR3E: 5-hydroxytryptamine receptor 3E

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HTR3E: 5-hydroxytryptamine receptor 3E. Genes, record 285242. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/285242

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Gene

Symbol
HTR3E
HGNC
Name
5-hydroxytryptamine receptor 3E
HGNC
NCBI Gene ID
285242
NCBI Gene
HGNC ID
HGNC:24005
HGNC
Ensembl
ENSG00000186038
NCBI Gene
Aliases
5-HT3-E, 5-HT3E, 5-HT3c1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
A5X5Y05-hydroxytryptamine receptor 3E4560Ensembl, GeneID, HGNC

Source UniProt

Patents12

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435771A5X5Y0Espacenet
EP 4650780 A22025-11-1913095A5X5Y0Espacenet
JP 2025529142 A2025-09-042012A5X5Y0Espacenet
US 12371689 B22025-07-292012A5X5Y0Espacenet
JP 2025517970 A2025-06-1213095A5X5Y0Espacenet
JP 2025062604 A2025-04-14419A5X5Y0Espacenet
US 11446398 B22022-09-20419A5X5Y0Espacenet
JP 2022524081 A2022-04-27103390A5X5Y0Espacenet
US 11078247 B22021-08-035247A5X5Y0Espacenet
JP 2019054813 A2019-04-11216206A5X5Y0Espacenet

1 to 10 of 12

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Drugs15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
CLOTHIAPINECHEMBL304902Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
FACINICLINECHEMBL2151439Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
FACINICLINE HYDROCHLORIDECHEMBL5095032Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
MOSAPRIDECHEMBL60889Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
PUMOSETRAGCHEMBL1643880Serotonin 3 (5-HT3) receptor partial agonistPARTIAL AGONISTChEMBL
RAMOSETRONCHEMBL1643895Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
RAMOSETRON HYDROCHLORIDECHEMBL3181841Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL

1 to 10 of 15

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Trials67

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07152184AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06887621AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06585540AMISULPRIDEPHASE3ClinicalTrials.gov
NCT06581302AMISULPRIDEClinicalTrials.gov
NCT06166615RAMOSETRONPHASE2/PHASE3ClinicalTrials.gov
NCT06040944AMISULPRIDEClinicalTrials.gov
NCT05956600AMISULPRIDEClinicalTrials.gov
NCT05347199AMISULPRIDEPHASE1ClinicalTrials.gov
NCT04954365AMISULPRIDEClinicalTrials.gov
NCT04533724AMISULPRIDEEARLY_PHASE1ClinicalTrials.gov

1 to 10 of 67

See all 67 trials

NIH grants119

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTR3E papersNewest fiscal year
K12DA000167Clinician Scientist Training Program (CSTP)12025
K24HL133373Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy12025
P30CA124435Stanford Cancer Institute12025
R01EB023281FreeSurfer Development, Maintenance, and Hardening12025
T32HG000044Institutional Training Grant in Genome Science12025
T32HG008961UAB-HudsonAlpha Genomic Medicine Training Program12025
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged12025
U24HG006673Systematic Exploration of the Human Interactome IV12025
ZIAHG000140Comparative Genomic Studies on the Evolution of Morphological Complexity12025
R01DK099611Effect of neonatal and adult stress on pelvic pain disorders and comorbidity12024

1 to 10 of 119Source NIH's project files

See all 119 nih grants

Papers191

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Neurotransmitter Systems in Alzheimer's Disease.Curr Issues Mol Biol202641899485PubTator, text miningPubMed
Quantifying the fidelity of in vitro human cell culture systems using a biomedical foundation model.Proc Natl Acad Sci U S A202641860964PubTator, text miningPubMed
Beyond Stigma-Integrating Neurobiology, Genetics, and Awareness Integration Theory in Addiction Recovery.Psychol Res Behav Manag202641710726PubTator, text miningPubMed
Detection of serotonin and serotonin related gene reveals unique roles in human intestinal epithelial development.bioRxiv202541377494PubTator, text miningPubMed
Genes related to neurotransmitter receptors as potential biomarkers for Alzheimer's disease.Neurosci Lett202438729598PubTator, text miningPubMed
Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies.Neural Regen Res202437843213PubTator, text miningPubMed
Spatiotemporal expression patterns of anxiety disorder-associated genes.Transl Psychiatry202338092764PubTator, text miningPubMed
Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases.Behav Neurol202338058356PubTator, text miningPubMed
A randomized trial evaluating the association between related gene polymorphism and nausea and vomiting induced by cisplatin multi-day chemotherapy.BMC Med Genomics202337924126PubTator, text miningPubMed
The Association of HHV-6 and the TNF-α (-308G/A) Promotor with Major Depressive Disorder Patients and Healthy Controls in Thailand.Viruses202337766304PubTator, text miningPubMed

1 to 10 of 191

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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