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Gene · 2862

MLNR: motilin receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MLNR: motilin receptor. Genes, record 2862. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2862

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Gene

Symbol
MLNR
HGNC
Name
motilin receptor
HGNC
NCBI Gene ID
2862
NCBI Gene
HGNC ID
HGNC:4495
HGNC
Ensembl
ENSG00000102539
NCBI Gene
Aliases
GPR38, MTLR1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43193Motilin receptor4124Ensembl, GeneID, HGNC

Source UniProt

Patents34

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454077O43193Espacenet
JP 2025529142 A2025-09-042657O43193Espacenet
US 12371689 B22025-07-292657O43193Espacenet
US 11446398 B22022-09-2052943O43193Espacenet
US 11400116 B22022-08-022396O43193Espacenet
JP 2022524081 A2022-04-27155914O43193Espacenet
KR 1020210133200 A2021-11-054O43193Espacenet
KR 1020210120699 A2021-10-074O43193Espacenet
US 11078247 B22021-08-036854O43193Espacenet
US 10772934 B22020-09-151014O43193Espacenet

1 to 10 of 34

See all 34 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATILMOTINCHEMBL2369989Motilin receptor agonistAGONISTChEMBL
CAMICINALCHEMBL489095Motilin receptor agonistAGONISTChEMBL
MITEMCINALCHEMBL2110756Motilin receptor agonistAGONISTChEMBL
MITEMCINAL FUMARATECHEMBL2105890Motilin receptor agonistAGONISTChEMBL

Trials5

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02210000CAMICINALPHASE22017-11-01ClinicalTrials.gov
NCT01602549CAMICINALPHASE22017-02-06ClinicalTrials.gov
NCT01262898CAMICINALPHASE22017-10-13ClinicalTrials.gov
NCT00861809CAMICINALPHASE2ClinicalTrials.gov
NCT00050882MITEMCINAL FUMARATEPHASE2ClinicalTrials.gov

NIH grants208

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMLNR papersNewest fiscal year
U01DK073975Temple University Gastroparesis Clinical Center42025
U01CA209414The Boston Lung Cancer Survival Cohort32025
U01DK073983Advancing Science for the Diagnosis and Treatment of Gastroparesis32025
U01DK074007U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium32025
P30ES023515Mount Sinai Center for Health and Environment Across the LifeSpan (HEALS)22025
U01DK074035A multicenter, double-blind, randomized, placebo- controlled, parallel study to assess the efficacy of 5- HT4 agonist prucalopride for the treatment of diabetic and idiopathic gastroparesis22025
UH3OD023337Mount Sinai ECHO site for Perinatal Environment and Development Studies22025
I01BX001991Molecular Mechanisms of Stellate Cell Activation in Liver Fibrosis12025
P30CA015704Cancer Center Support Grant12025
P30CA016042Cancer Center Support Grant12025

1 to 10 of 208Source NIH's project files

See all 208 nih grants

Papers570

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Motilin in amphibians.Gen Comp Endocrinol202641935755PubTator, text miningPubMed
Treating the Patient, Not Only the Amyloid: Symptomatic Management in Transthyretin Amyloidosis.Neurol Int202641893055PubTator, text miningPubMed
Biosynthesis, Chemical Synthesis, and Pharmacological Evaluation of Lyngbyapeptin A as a GPCR Antagonist of Motilin, Cannabinoid, and Amylin Receptors.J Nat Prod202541105455PubTator, text miningPubMed
Azithromycin and oesophageal motility in chronic respiratory disease: a feasibility study.Ther Adv Respir Dis202540734318PubTator, text miningPubMed
[Prediction of immunotherapy targets for chronic cerebral hypoperfusion by bioinformatics method].Sheng Wu Yi Xue Gong Cheng Xue Za Zhi202540288982PubTator, text miningPubMed
Decoding the structural basis of ligand recognition and biased signaling in the motilin receptor.Cell Rep202539987561PubTator, text miningPubMed
Bitter-tasting drugs tune GDF15 and GLP-1 expression via bitter taste or motilin receptors in the intestine of patients with obesity.Mol Metab202439111389PubTator, text miningPubMed
Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis.Cell Rep202438676926PubTator, text miningPubMed
Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute pancreatitis.Sci Adv202438306436PubTator, text miningPubMed
A novel macrolide-Del-1 axis to regenerate bone in old age.iScience202438261928PubTator, text miningPubMed

1 to 10 of 570

See all 570 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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