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Gene · 2864

FFAR1: free fatty acid receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FFAR1: free fatty acid receptor 1. Genes, record 2864. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2864

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Gene

Symbol
FFAR1
HGNC
Name
free fatty acid receptor 1
HGNC
NCBI Gene ID
2864
NCBI Gene
HGNC ID
HGNC:4498
HGNC
Ensembl
ENSG00000126266
NCBI Gene
Aliases
FFA1R, GPCR40, GPR40
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14842Free fatty acid receptor 13009Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025529142 A2025-09-041566O14842Espacenet
US 12371689 B22025-07-291566O14842Espacenet
EP 4514831 A12025-03-053O14842Espacenet
US 11583528 B22023-02-2134O14842Espacenet
US 11446398 B22022-09-2032886O14842Espacenet
US 11400116 B22022-08-023269O14842Espacenet
JP 2022524081 A2022-04-27135857O14842Espacenet
US 11078247 B22021-08-033998O14842Espacenet
US 10772934 B22020-09-151072O14842Espacenet
US 10668104 B22020-06-0213O14842Espacenet

1 to 10 of 50

See all 50 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
FASIGLIFAMCHEMBL1829174Free fatty acid receptor 1 positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
LY2881835CHEMBL3915620Free fatty acid receptor 1 agonistAGONISTChEMBL
SETOGEPRAMCHEMBL4297635Free fatty acid receptor 1 agonistAGONISTChEMBL

Trials24

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03184584SETOGEPRAMPHASE2/PHASE3ClinicalTrials.gov
NCT03081598SETOGEPRAMPHASE2ClinicalTrials.gov
NCT02955888SETOGEPRAMPHASE2ClinicalTrials.gov
NCT02739217SETOGEPRAMPHASE2ClinicalTrials.gov
NCT02562573SETOGEPRAMPHASE2ClinicalTrials.gov
NCT02538536SETOGEPRAMPHASE2ClinicalTrials.gov
NCT02015780FASIGLIFAMPHASE3ClinicalTrials.gov
NCT01982253FASIGLIFAMPHASE22016-10-07ClinicalTrials.gov
NCT01834274FASIGLIFAMPHASE32015-09-28ClinicalTrials.gov
NCT01829477FASIGLIFAMPHASE32016-06-01ClinicalTrials.gov

1 to 10 of 24

See all 24 trials

NIH grants608

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFFAR1 papersNewest fiscal year
P30DK063491Diabetes Research Center (DRC)42025
R35GM128641Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammation42025
P30DK056341Washington University Nutrition Obesity Research Center32025
R01EY017017Dietary control of angiogenesis in retinopathy models32025
P01HL151328Triglycerides, Diabetes and Cardiovascular Disease22025
P30DK020572Michigan Diabetes Research Center (MDRC)22025
P30DK020593Vanderbilt Diabetes Research Center22025
P30DK034854Integrated Epithelial and Muscosal Biology22025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital22025
P30DK058404Molecular and Cellular Basis for Digestive Diseases22025

1 to 10 of 608Source NIH's project files

See all 608 nih grants

Papers1,574

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Decoding dietary fat: molecular sensing, brain integration, and the biology of flavor.Can J Physiol Pharmacol202642826400PubTator, text miningPubMed
Molecular mechanisms of lipid sensing in human cholecystokinin-secreting enteroendocrine cells.Mol Metab202642805486PubTator, text miningPubMed
Sphinganine as a novel stimulator of GLP-1 secretion.Diabetologia202642782508PubTator, text miningPubMed
Effects of Fluoride and 8:2 FTOH on β-Cell Calcium Signaling and Insulin Homeostasis: An Exploratory Study.Metabolites202642506423PubTator, text miningPubMed
Synthesis and structure-activity relationship evaluation of hypoglycemic activity of novel borneol and isoborneol containing (hydroxyphenyl)propanoic acids as FFAR1 agonists.Med Chem Res202642446660PubTator, text miningPubMed
Maternal obesity induces macrophage to myofibroblast transition in kidneys of male offspring through a pathway driven by 20-hydroxyeicosatetraenoic acid.Nat Commun202642135322PubTator, text miningPubMed
Revisiting GPR40 Agonist in Type 2 Diabetes Mellitus: A Cautious but Meaningful Return.Diabetes Metab J202642128401PubTator, text miningPubMed
The Ca2+-NO-ROS Crosstalk Induced by Arachidonic Acid in Human Lung Fibroblasts: Implications for Pulmonary Fibrosis.Int J Mol Sci202642123594PubTator, text miningPubMed
The roles of free-fatty acid receptors in the pathophysiology of renal disorders.J Pharmacol Exp Ther202642096898PubTator, text miningPubMed
Short-, medium-, versus long-chain fatty acids: mechanisms of immunomodulation and disease pathogenesis.Cell Mol Immunol202642056219PubTator, text miningPubMed

1 to 10 of 1,574

See all 1,574 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2864

GET https://conductscience.org/api/genes/v1/2864/patents?page=2