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Gene · 2867

FFAR2: free fatty acid receptor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FFAR2: free fatty acid receptor 2. Genes, record 2867. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2867

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Gene

Symbol
FFAR2
HGNC
Name
free fatty acid receptor 2
HGNC
NCBI Gene ID
2867
NCBI Gene
HGNC ID
HGNC:4501
HGNC
Ensembl
ENSG00000126262
NCBI Gene
Aliases
FFA2R, GPR43
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15552Free fatty acid receptor 233011Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025529142 A2025-09-041567O15552Espacenet
US 12371689 B22025-07-291567O15552Espacenet
US 12006548 B22024-06-11434O15552Espacenet
US 11446398 B22022-09-2032887O15552Espacenet
US 11446398 B22022-09-2032888O15552Espacenet
US 11400116 B22022-08-023270O15552Espacenet
JP 2022524081 A2022-04-27135858O15552Espacenet
JP 2022524081 A2022-04-27135859O15552Espacenet
US 11078247 B22021-08-033999O15552Espacenet
US 10975437 B22021-04-13434O15552Espacenet

1 to 10 of 60

See all 60 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
GLPG-0974CHEMBL3353541Free fatty acid receptor 2 antagonistANTAGONIST

Source ChEMBL

Trials1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first posted
NCT01829321GLPG-0974PHASE2

NIH grants976

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFFAR2 papersNewest fiscal year
R01CA154426Colorectal carcinogenesis and Fusobacterium nucleatum: oncomicrobe, oncometabolites, and oncoimmunology72025
P30DK020595Diabetes Research and Training Center52025
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)52025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital52025
I01BX003382Role of Nutrient Sensing Receptors for the Gut Microbiota in Metabolism42025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)42025
P30DK048520Colorado Nutrition Obesity Research Center42025
P30DK063491Diabetes Research Center (DRC)42025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
P30DK056338Texas Medical Center Digestive Diseases Center32025

1 to 10 of 976Source NIH's project files

See all 976 nih grants

Papers2,791

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Decoding dietary fat: molecular sensing, brain integration, and the biology of flavor.Can J Physiol Pharmacol202642826400PubTator, text miningPubMed
Gut microbiota-host co-metabolism in hypertriglyceridemia-associated acute pancreatitis: from causality to precision intervention.Front Immunol202642819668PubTator, text miningPubMed
Butyrate triggers neuronal signaling via release of colonic serotonin in a microfluidic model of gut-brain axis.Am J Physiol Gastrointest Liver Physiol202642814738PubTator, text miningPubMed
Molecular mechanisms of lipid sensing in human cholecystokinin-secreting enteroendocrine cells.Mol Metab202642805486PubTator, text miningPubMed
Short-Chain Fatty Acids in Sepsis: Mechanisms of Action and Therapeutic Advances.Biomedicines202642792734PubTator, text miningPubMed
Gut microbiota regulation of the IL-6/STAT3 pathway: Linking hematopoiesis to colorectal cancer progression.Int Immunopharmacol202642767102PubTator, text miningPubMed
Short-Chain Fatty Acids and FFAR2: Modulators of the Gut-Brain Axis in Neuroinflammatory Disorders.Curr Pharm Des202642725615PubTator, text miningPubMed
FFAR2 activation induces IL-22-dependent intestinal immune responses to suppress CNS autoimmunity.EMBO Mol Med202642693313PubTator, text miningPubMed
Universal pipeline for high-resolution GPCR structure determination.Nat Struct Mol Biol202642665663PubTator, text miningPubMed
Sodium butyrate upregulates URAT1-mediated urate reabsorption in HK2 cells by activating FFAR2/p38 MAPK/ELK1/ARRB2 axis and relieving NF-κB-HNF1β competitive binding.Biochem Pharmacol202642546882PubTator, text miningPubMed

1 to 10 of 2,791

See all 2,791 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2867

GET https://conductscience.org/api/genes/v1/2867/patents?page=2