Gene · 2867
FFAR2: free fatty acid receptor 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FFAR2: free fatty acid receptor 2. Genes, record 2867. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2867
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15552 | Free fatty acid receptor 2 | 330 | 11 | Ensembl, GeneID, HGNC |
Source UniProt
Patents60
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025529142 A | 2025-09-04 | 1567 | O15552 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1567 | O15552 | Espacenet |
| US 12006548 B2 | 2024-06-11 | 434 | O15552 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 32887 | O15552 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 32888 | O15552 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3270 | O15552 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 135858 | O15552 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 135859 | O15552 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 3999 | O15552 | Espacenet |
| US 10975437 B2 | 2021-04-13 | 434 | O15552 | Espacenet |
1 to 10 of 60
See all 60 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| GLPG-0974 | CHEMBL3353541 | Free fatty acid receptor 2 antagonist | ANTAGONIST |
Source ChEMBL
Trials1
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted |
|---|---|---|---|
| NCT01829321 | GLPG-0974 | PHASE2 |
Source ClinicalTrials.gov
NIH grants976
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FFAR2 papers | Newest fiscal year |
|---|---|---|---|
| R01CA154426 | Colorectal carcinogenesis and Fusobacterium nucleatum: oncomicrobe, oncometabolites, and oncoimmunology | 7 | 2025 |
| P30DK020595 | Diabetes Research and Training Center | 5 | 2025 |
| P30DK042086 | Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID) | 5 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 5 | 2025 |
| I01BX003382 | Role of Nutrient Sensing Receptors for the Gut Microbiota in Metabolism | 4 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 4 | 2025 |
| P30DK048520 | Colorado Nutrition Obesity Research Center | 4 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 4 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 3 | 2025 |
1 to 10 of 976Source NIH's project files
See all 976 nih grantsPapers2,791
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Decoding dietary fat: molecular sensing, brain integration, and the biology of flavor. | Can J Physiol Pharmacol | 2026 | 42826400 | PubTator, text mining | PubMed |
| Gut microbiota-host co-metabolism in hypertriglyceridemia-associated acute pancreatitis: from causality to precision intervention. | Front Immunol | 2026 | 42819668 | PubTator, text mining | PubMed |
| Butyrate triggers neuronal signaling via release of colonic serotonin in a microfluidic model of gut-brain axis. | Am J Physiol Gastrointest Liver Physiol | 2026 | 42814738 | PubTator, text mining | PubMed |
| Molecular mechanisms of lipid sensing in human cholecystokinin-secreting enteroendocrine cells. | Mol Metab | 2026 | 42805486 | PubTator, text mining | PubMed |
| Short-Chain Fatty Acids in Sepsis: Mechanisms of Action and Therapeutic Advances. | Biomedicines | 2026 | 42792734 | PubTator, text mining | PubMed |
| Gut microbiota regulation of the IL-6/STAT3 pathway: Linking hematopoiesis to colorectal cancer progression. | Int Immunopharmacol | 2026 | 42767102 | PubTator, text mining | PubMed |
| Short-Chain Fatty Acids and FFAR2: Modulators of the Gut-Brain Axis in Neuroinflammatory Disorders. | Curr Pharm Des | 2026 | 42725615 | PubTator, text mining | PubMed |
| FFAR2 activation induces IL-22-dependent intestinal immune responses to suppress CNS autoimmunity. | EMBO Mol Med | 2026 | 42693313 | PubTator, text mining | PubMed |
| Universal pipeline for high-resolution GPCR structure determination. | Nat Struct Mol Biol | 2026 | 42665663 | PubTator, text mining | PubMed |
| Sodium butyrate upregulates URAT1-mediated urate reabsorption in HK2 cells by activating FFAR2/p38 MAPK/ELK1/ARRB2 axis and relieving NF-κB-HNF1β competitive binding. | Biochem Pharmacol | 2026 | 42546882 | PubTator, text mining | PubMed |
1 to 10 of 2,791
See all 2,791 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2867
GET https://conductscience.org/api/genes/v1/2867/patents?page=2