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Gene · 2877

GPX2: glutathione peroxidase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GPX2: glutathione peroxidase 2. Genes, record 2877. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2877

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Gene

Symbol
GPX2
HGNC
Name
glutathione peroxidase 2
HGNC
NCBI Gene ID
2877
NCBI Gene
HGNC ID
HGNC:4554
HGNC
Ensembl
ENSG00000176153
NCBI Gene
Aliases
GI-GPx, GPRP, GPRP-2, GPx-2, GPx-GI, GSHPX-GI, GSHPx-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P18283Glutathione peroxidase 21901Ensembl, GeneID, HGNC

Source UniProt

Patents7

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447876P18283Espacenet
EP 4640849 A22025-10-291639P18283Espacenet
EP 4641201 A22025-10-2911106P18283Espacenet
WO 2025163153 A22025-08-0738P18283Espacenet
JP 2025519096 A2025-06-241639P18283Espacenet
JP 2025517969 A2025-06-1211106P18283Espacenet
WO 2024231419 A12024-11-144P18283Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,143

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGPX2 papersNewest fiscal year
P30ES006694Southwest Environmental Health Sciences Center72025
P30CA008748Cancer Center Support Grant62025
P30ES010126UNC Center for Environmental Health and Susceptibility62025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures62025
P30CA068485Cancer Center Support Grant52025
P30CA016086Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant42025
P30DK058404Molecular and Cellular Basis for Digestive Diseases42025
P30CA012197Cancer Center Support Grant32025

1 to 10 of 1,143Source NIH's project files

See all 1,143 nih grants

Papers1,817

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Concordant transcriptomics analysis of the lungs and blood after exposure to diesel exhaust: A randomized, controlled human exposure study.Environ Res202642722095PubTator, text miningPubMed
Transcriptional insights into liver toxicity from mixture effects of pesticides and natural toxins: A case study of propyzamide and microcystins.Toxicology202642710566PubTator, text miningPubMed
Phillygenin protects against lipopolysaccharide-induced acute lung injury by acting as a PXR agonist via NF-κB inhibition.Sci Rep202642686835PubTator, text miningPubMed
Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer.Adv Sci (Weinh)202642610521PubTator, text miningPubMed
ZDHHC16-induced GPX2 S-palmitoylation promotes lenvatinib resistance and inhibits lenvatinib-induced immunogenic cell death in hepatocellular carcinoma.Drug Resist Updat202642497564PubTator, text miningPubMed
Hydrolyzed corn starch with maltotetraose for skin defense through NRF2 pathway activation in human keratinocytes.PLoS One202642361126PubTator, text miningPubMed
Regulation of Glutathione Peroxidases (GPxs) in Breast Cancer: From Mechanisms to Targeted Therapeutics.J Biochem Mol Toxicol202642224423PubTator, text miningPubMed
Glutathione peroxidase 2 expression in human tumors: a tissue microarray study on 18,555 tumors.Front Oncol202642158439PubTator, text miningPubMed
CT-based immune radiomic signature for prognosis and prediction of immunotherapy and anticancer drug response in NSCLC.Front Immunol202642136648PubTator, text miningPubMed
USP10 confers lenvatinib resistance in hepatocellular carcinoma by deubiquitinating the GPX2.Cell Oncol (Dordr)202642133228PubTator, text miningPubMed

1 to 10 of 1,817

See all 1,817 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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