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Gene · 2878

GPX3: glutathione peroxidase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GPX3: glutathione peroxidase 3. Genes, record 2878. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2878

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Gene

Symbol
GPX3
HGNC
Name
glutathione peroxidase 3
HGNC
NCBI Gene ID
2878
NCBI Gene
HGNC ID
HGNC:4555
HGNC
Ensembl
ENSG00000211445
NCBI Gene
Aliases
GPx-P, GSHPx-3, GSHPx-P
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22352Glutathione peroxidase 32261Ensembl, GeneID, HGNC

Source UniProt

Patents7

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1910639P22352Espacenet
JP 2025529142 A2025-09-046535P22352Espacenet
WO 2025163153 A22025-08-0739P22352Espacenet
US 12371689 B22025-07-296535P22352Espacenet
JP 2025517970 A2025-06-1210639P22352Espacenet
WO 2024231419 A12024-11-145P22352Espacenet
JP 2024038290 A2024-03-1941P22352Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,519

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGPX3 papersNewest fiscal year
R01GM102187Chemical Tools for Probing Cysteine Sulfenation and Sulfination Redox Biology132025
P30CA068485Cancer Center Support Grant62025
P30DK058404Molecular and Cellular Basis for Digestive Diseases62025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures62025
P30CA033572Cancer Center Support Grant52025
P30ES006694Southwest Environmental Health Sciences Center52025
P30CA008748Cancer Center Support Grant42025
P30CA015704Cancer Center Support Grant42025
P30DK063491Diabetes Research Center (DRC)42025
P30ES005605Environmental Health Sciences Research Center42025

1 to 10 of 1,519Source NIH's project files

See all 1,519 nih grants

Papers2,921

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transcriptome-based epigenetic screening identifies DNA hypermethylation signatures as prognostic biomarkers in oral squamous cell carcinoma.Mol Biomed202642749952PubTator, text miningPubMed
Effects of Hyperbaric Oxygen Combined with Lycopene on Oxidative Stress and Inflammation in Collegiate Badminton Players After High-Intensity Training.Nutrients202642739033PubTator, text miningPubMed
The GPX3-VCAM1 Axis Gates Pro-Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy.Adv Sci (Weinh)202642717509PubTator, text miningPubMed
GPX3 suppresses lung adenocarcinoma progression through HSPB1 ubiquitination and Hippo pathway activation.Cell Rep202642684887PubTator, text miningPubMed
Transcriptomic Analysis Reveals Core Genes and Mechanisms Linking Grilled Food Toxicants (4-HNE, BaP, PhIP) to NASH-HCC Progression.Food Sci Nutr202642682783PubTator, text miningPubMed
Sex-Associated Proteomic Signatures Persist Independent of Injury Severity and Shock Physiology in Acute Trauma.Shock202642625553PubTator, text miningPubMed
Molecular Mechanisms Governing Vascular Function in Heart Failure.Arterioscler Thromb Vasc Biol202642619591PubTator, text miningPubMed
Integrative transcriptomics and single-cell analysis identify SIX4 as a candidate epithelial target in ovarian cancer and PCOS-associated ovarian dysregulation.Transl Oncol202642546664PubTator, text miningPubMed
Gamete co-incubation duration modulates blastocyst developmental competence in buffalo through regulation of growth factors, steroidogenesis and oxidative stress pathways.Mol Biol Rep202642489973PubTator, text miningPubMed
Alginate oligosaccharides improve breast muscle quality of heat-stressed broilers by modulating oxidative stability, muscle fiber transformation, and lipid metabolism.Food Chem202642475991PubTator, text miningPubMed

1 to 10 of 2,921

See all 2,921 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2878

GET https://conductscience.org/api/genes/v1/2878/grants?page=2