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GPX4: glutathione peroxidase 4

1 protein, 8 patents, 0 drugs, 0 trials, 2,672 NIH grants and 12,803 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGPX4HGNC
Nameglutathione peroxidase 4HGNC
NCBI Gene ID2879NCBI Gene
HGNC IDHGNC:4556HGNC
EnsemblENSG00000167468NCBI Gene
AliasesGPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPxNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P36969Phospholipid hydroperoxide glutathione peroxidase GPX419723Ensembl, GeneID, HGNCUniProt

Patents 8

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4752548 A12026-06-036P36969Espacenet
JP 2026004568 A2026-01-1447877P36969Espacenet
EP 4650780 A22025-11-197032P36969Espacenet
JP 2025529142 A2025-09-046536P36969Espacenet
WO 2025163153 A22025-08-078P36969Espacenet
US 12371689 B22025-07-296536P36969Espacenet
JP 2025517970 A2025-06-127032P36969Espacenet
WO 2024231419 A12024-11-146P36969Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2672

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant352,025NIH's project files
P30CA016672Cancer Center Support Grant312,025NIH's project files
R01NS076511Lipid Imaging in Traumatic Brain Injury by High Resolution GCIB-secondary Ion Mass Spectrometry252,025NIH's project files
R01GM122923Characterizing the Regulation of Ferroptosis212,025NIH's project files
R01CA247992Targeting ferroptosis in radioresistance in lung cancer: mechanisms and preclinical translation202,025NIH's project files
R01CA204232Ferroptosis, Cellular Metabolism, and Cancer172,025NIH's project files
P30CA086862Cancer Center Support Grant152,025NIH's project files
P30CA013696Cancer Center Support Grant122,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program112,025NIH's project files
P30AG013319San Antonio Nathan Shock Center of Excellence in the Biology of Aging102,025NIH's project files

Papers 12803

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826872PubTator, text miningPubMed
42826770PubTator, text miningPubMed
42826448PubTator, text miningPubMed
42825373PubTator, text miningPubMed
42822756PubTator, text miningPubMed
42821430PubTator, text miningPubMed
42819585PubTator, text miningPubMed
42819418PubTator, text miningPubMed
42819154PubTator, text miningPubMed
42816875PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license