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GRB2: growth factor receptor bound protein 2

1 protein, 138 patents, 1 drug, 3 trials, 5,659 NIH grants and 9,727 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGRB2HGNC
Namegrowth factor receptor bound protein 2HGNC
NCBI Gene ID2885NCBI Gene
HGNC IDHGNC:4566HGNC
EnsemblENSG00000177885NCBI Gene
AliasesASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P62993Growth factor receptor-bound protein 221758Ensembl, GeneID, HGNCUniProt

Patents 138

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4808601 A12026-09-23443P62993Espacenet
JP 2026117012 A2026-07-141P62993Espacenet
JP 2026102799 A2026-06-2310P62993Espacenet
EP 4661970 A12025-12-1762150P62993Espacenet
EP 4650780 A22025-11-196398P62993Espacenet
JP 2025517970 A2025-06-126398P62993Espacenet
JP 2025513427 A2025-04-24443P62993Espacenet
JP 2025038035 A2025-03-184407P62993Espacenet
EP 4511495 A22025-02-26443P62993Espacenet
WO 2024240908 A12024-11-2824P62993Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PREXIGEBERSENCHEMBL3989978Growth factor receptor-bound protein 2 mRNA antisense inhibitorANTISENSE INHIBITORChEMBL

Trials 3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02923986PREXIGEBERSENPHASE1/PHASE2ClinicalTrials.gov
NCT02781883PREXIGEBERSENPHASE2ClinicalTrials.gov
NCT01159028PREXIGEBERSENPHASE1ClinicalTrials.gov

NIH grants 5659

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant712,025NIH's project files
P30CA008748Cancer Center Support Grant372,025NIH's project files
ZIABC006198Inhibitors of Tyrosine Kinase-Dependent Signaling as Anti-Cancer Agents282,025NIH's project files
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR252,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant192,025NIH's project files
ZIABC010304Biochemical Basis of T Cell Activation172,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase162,025NIH's project files
P30CA086862Cancer Center Support Grant152,025NIH's project files
P30CA016058Cancer Center Support Grant142,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant132,025NIH's project files

Papers 9727

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42793099PubTator, text miningPubMed
42720986PubTator, text miningPubMed
42664822PubTator, text miningPubMed
42633444PubTator, text miningPubMed
42617725PubTator, text miningPubMed
42593687PubTator, text miningPubMed
42574606PubTator, text miningPubMed
42560817PubTator, text miningPubMed
42508775PubTator, text miningPubMed
42487683PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license