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Gene · 28882

IGKV2D-29: immunoglobulin kappa variable 2D-29

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IGKV2D-29: immunoglobulin kappa variable 2D-29. Genes, record 28882. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/28882

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Gene

Symbol
IGKV2D-29
HGNC
Name
immunoglobulin kappa variable 2D-29
HGNC
NCBI Gene ID
28882
NCBI Gene
HGNC ID
HGNC:5800
HGNC
Ensembl
ENSG00000243264
NCBI Gene
Aliases
A2a, A2c, IGKV2D29
NCBI Gene
Type
other
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
A0A075B6S2Immunoglobulin kappa variable 2D-291200Ensembl, HGNC

Source UniProt

Patents6

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1914125A0A075B6S2Espacenet
JP 2025517970 A2025-06-1214125A0A075B6S2Espacenet
US 11446398 B22022-09-2039848A0A075B6S2Espacenet
JP 2022524081 A2022-04-27142819A0A075B6S2Espacenet
WO 2020043864 A12020-03-051312A0A075B6S2Espacenet
WO 2019180264 A12019-09-2630A0A075B6S2Espacenet

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,968

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIGKV2D-29 papersNewest fiscal year
ZIADK031117Development of Drugs Acting at Adenosine Receptors822025
ZIADA000493Functional and Pharmacological Significance of Receptor Heteromers in the CNS252025
ZIADK031126Computer Modeling of G Protein-Coupled Receptors222025
ZIADK031115Functionalized Congeners of Bioactive Compounds212025
ZIADK031116Development of P2Y Receptor Ligands142025
ZIAAA000375Mechanism of oxidative/nitrosative stress and inflammation-induced tissue injury82025
P30EY001583P30 Core Grant For Vision Research52025
R01DK095491Indole dysbiosis and mucosal inflammation52025
R35GM136397GPCR anterograde trafficking42025
UL1TR001445Clinical and Translational Science Award42025

1 to 10 of 1,968Source NIH's project files

See all 1,968 nih grants

Papers3,857

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Pantoprazole as a potential repurposed drug targeting the adenosinergic system in esophageal cancer.Med Chem Res202642789078PubTator, text miningPubMed
Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder.Front Mol Neurosci202642781299PubTator, text miningPubMed
Developmental changes in Ca2+ signaling mediated by A2A adenosine and mGluR5 glutamate receptors in olfactory bulb astrocytes.Sci Rep202642660969PubTator, text miningPubMed
Reprogramming the immunosuppressive microenvironment in glioblastoma: the microglia-MDSC-Treg axis and translational therapeutic strategies.Front Oncol202642639384PubTator, text miningPubMed
Quantifying Heteromer Partitioning Reveals Inflammation-Dependent Redistribution of Microglial Adenosine A2A and Cannabinoid CB2 Receptors.Glia202642482393PubTator, text miningPubMed
Inflammation, oxidative stress and purinergic signaling in pituitary neuroendocrine tumors (PitNETs).Purinergic Signal202642412139PubTator, text miningPubMed
Circulating ATP from hepatic ischemia-reperfusion drives remote cardiac injury via macrophage inflammasome activation.Pharmacol Res202642309495PubTator, text miningPubMed
Computational evaluation of leflunomide and ticagrelor combination targeting the A2A receptor for the management of rheumatoid arthritis.Pak J Pharm Sci202642262197PubTator, text miningPubMed
Adenosine Signaling in Primary and Metastatic Brain Tumors: Immune Suppression, Tumor Progression, and Therapeutic Opportunities.Mol Neurobiol202642168394PubTator, text miningPubMed
Discovery of Potent 1,3-Cyclobutane-Containing Dual A2A/A2B Receptor Antagonists with Low Projected Human Dose for the Treatment of Cancer.ACS Med Chem Lett202642157841PubTator, text miningPubMed

1 to 10 of 3,857

See all 3,857 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/28882

GET https://conductscience.org/api/genes/v1/28882/grants?page=2