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GRIA1: glutamate ionotropic receptor AMPA type subunit 1

1 protein, 34 patents, 16 drugs, 240 trials, 3,915 NIH grants and 5,578 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGRIA1HGNC
Nameglutamate ionotropic receptor AMPA type subunit 1HGNC
NCBI Gene ID2890NCBI Gene
HGNC IDHGNC:4571HGNC
EnsemblENSG00000155511NCBI Gene
AliasesGLUH1, GLUR1, GLURA, GluA1, HBGR1, MRD67, MRT76NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P42261Glutamate receptor 19061Ensembl, GeneID, HGNCUniProt

Patents 34

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447719P42261Espacenet
EP 4650780 A22025-11-193271P42261Espacenet
EP 4641201 A22025-10-292844P42261Espacenet
JP 2025529142 A2025-09-041863P42261Espacenet
US 12371689 B22025-07-291863P42261Espacenet
JP 2025517969 A2025-06-122844P42261Espacenet
JP 2025517970 A2025-06-123271P42261Espacenet
JP 2025032204 A2025-03-1129303P42261Espacenet
EP 4461818 A22024-11-1329303P42261Espacenet
EP 4403184 A12024-07-245P42261Espacenet

Drugs 16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BECAMPANELCHEMBL3989682Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
CX1739CHEMBL3707399Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
DASOLAMPANELCHEMBL2103869Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
FARAMPATORCHEMBL1276138Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
IRAMPANELCHEMBL29741Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
MIBAMPATORCHEMBL1277001Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
MK-8777CHEMBL3707401Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
OSAVAMPATORCHEMBL4594403Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
PERAMPANELCHEMBL1214124Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
PESAMPATORCHEMBL5095022Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

Trials 240

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07588750TOPIRAMATEClinicalTrials.gov
NCT07384624TOPIRAMATEPHASE1/PHASE2ClinicalTrials.gov
NCT07284069PERAMPANELEARLY_PHASE1ClinicalTrials.gov
NCT06347497TOPIRAMATEPHASE3ClinicalTrials.gov
NCT06299891TOPIRAMATEPHASE2ClinicalTrials.gov
NCT06248931TOPIRAMATEPHASE3ClinicalTrials.gov
NCT06243692TOPIRAMATEPHASE3ClinicalTrials.gov
NCT05958160TOPIRAMATEPHASE2/PHASE3ClinicalTrials.gov
NCT05915013PERAMPANELPHASE1ClinicalTrials.gov
NCT05786066PERAMPANELPHASE2ClinicalTrials.gov

NIH grants 3915

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DA009621Glutamate receptor plasticity underlying incubation of methamphetamine craving162,025NIH's project files
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect122,025NIH's project files
ZIANS002994Subunit-Specific Regulation Of Glutamate Receptors122,025NIH's project files
R01MH071316Rac-GEF signaling in dendritic spines112,025NIH's project files
ZIAAA000411Mouse models of stress disorders and addiction82,025NIH's project files
P40OD010440Caenorhabditis Genetics Center72,025NIH's project files
P51OD011132Emory National Primate Research Center72,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62,025NIH's project files
P60AA011605Molecular and Circuit Pathogenesis of Alcohol Use Disorders62,025NIH's project files
R01NS081248CaMKII Holoenzyme Mechanisms in Opposing Forms of Synaptic Plasticity62,025NIH's project files

Papers 5578

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42790339PubTator, text miningPubMed
42751926PubTator, text miningPubMed
42711740PubTator, text miningPubMed
42706681PubTator, text miningPubMed
42700912PubTator, text miningPubMed
42679033PubTator, text miningPubMed
42651084PubTator, text miningPubMed
42621255PubTator, text miningPubMed
42610232PubTator, text miningPubMed
42595198PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license