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GRIA2: glutamate ionotropic receptor AMPA type subunit 2

1 protein, 26 patents, 16 drugs, 240 trials, 3,605 NIH grants and 5,330 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGRIA2HGNC
Nameglutamate ionotropic receptor AMPA type subunit 2HGNC
NCBI Gene ID2891NCBI Gene
HGNC IDHGNC:4572HGNC
EnsemblENSG00000120251NCBI Gene
AliasesGLUR2, GLURB, GluA2, GluR-2, GluR-B, GluR-K2, HBGR2, NEDLIB, gluR-2, gluR-BNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P42262Glutamate receptor 288316Ensembl, GeneID, HGNCUniProt

Patents 26

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447727P42262Espacenet
EP 4650780 A22025-11-192350P42262Espacenet
EP 4641201 A22025-10-291922P42262Espacenet
JP 2025147176 A2025-10-066195P42262Espacenet
JP 2025529142 A2025-09-041864P42262Espacenet
JP 2025529142 A2025-09-046543P42262Espacenet
US 12371689 B22025-07-291864P42262Espacenet
US 12371689 B22025-07-296543P42262Espacenet
JP 2025517969 A2025-06-121922P42262Espacenet
JP 2025517970 A2025-06-122350P42262Espacenet

Drugs 16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BECAMPANELCHEMBL3989682Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
CX1739CHEMBL3707399Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
DASOLAMPANELCHEMBL2103869Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
FARAMPATORCHEMBL1276138Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
IRAMPANELCHEMBL29741Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
MIBAMPATORCHEMBL1277001Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
MK-8777CHEMBL3707401Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
OSAVAMPATORCHEMBL4594403Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL
PERAMPANELCHEMBL1214124Glutamate receptor ionotropic AMPA antagonistANTAGONISTChEMBL
PESAMPATORCHEMBL5095022Glutamate receptor ionotropic AMPA positive allosteric modulatorPOSITIVE ALLOSTERIC MODULATORChEMBL

Trials 240

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07588750TOPIRAMATEClinicalTrials.gov
NCT07384624TOPIRAMATEPHASE1/PHASE2ClinicalTrials.gov
NCT07284069PERAMPANELEARLY_PHASE1ClinicalTrials.gov
NCT06347497TOPIRAMATEPHASE3ClinicalTrials.gov
NCT06299891TOPIRAMATEPHASE2ClinicalTrials.gov
NCT06248931TOPIRAMATEPHASE3ClinicalTrials.gov
NCT06243692TOPIRAMATEPHASE3ClinicalTrials.gov
NCT05958160TOPIRAMATEPHASE2/PHASE3ClinicalTrials.gov
NCT05915013PERAMPANELPHASE1ClinicalTrials.gov
NCT05786066PERAMPANELPHASE2ClinicalTrials.gov

NIH grants 3605

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01CA206573Structure and function of Transient Receptor Potential Channels112,025NIH's project files
ZIANS002994Subunit-Specific Regulation Of Glutamate Receptors102,025NIH's project files
R01NS107253Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States82,025NIH's project files
ZIAHD001205Cellular And Synaptic Physiology Of Hippocampal Interneurons82,025NIH's project files
R01MH085926Structures and reagents of NMDA receptors62,025NIH's project files
R28AA012725Brain Tissue Resource Center for Alcohol Research62,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program52,025NIH's project files
P30CA016672Cancer Center Support Grant52,025NIH's project files
P30EY014800University of Utah Core Vision Research Grant52,025NIH's project files
P40OD010440Caenorhabditis Genetics Center52,025NIH's project files

Papers 5330

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824992PubTator, text miningPubMed
42799957PubTator, text miningPubMed
42798915PubTator, text miningPubMed
42775123PubTator, text miningPubMed
42702597PubTator, text miningPubMed
42700912PubTator, text miningPubMed
42651084PubTator, text miningPubMed
42610232PubTator, text miningPubMed
42576199PubTator, text miningPubMed
42353841PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license