Gene · 28935
IGKV1-27: immunoglobulin kappa variable 1-27
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. IGKV1-27: immunoglobulin kappa variable 1-27. Genes, record 28935. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/28935
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| A0A075B6S5 | Immunoglobulin kappa variable 1-27 | 117 | 0 | Ensembl, HGNC |
Source UniProt
Patents10
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 14255 | A0A075B6S5 | Espacenet |
| EP 4641203 A2 | 2025-10-29 | 509 | A0A075B6S5 | Espacenet |
| JP 2025517967 A | 2025-06-12 | 509 | A0A075B6S5 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 14255 | A0A075B6S5 | Espacenet |
| KR 1020250017230 A | 2025-02-04 | 509 | A0A075B6S5 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39802 | A0A075B6S5 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 39803 | A0A075B6S5 | Espacenet |
| US 11390673 B2 | 2022-07-19 | 55 | A0A075B6S5 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 142773 | A0A075B6S5 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 142774 | A0A075B6S5 | Espacenet |
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,236
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IGKV1-27 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| T32DK007007 | INRSA Training Grant in Gastroenterology | 7 | 2025 |
| R01HL089221 | Determinants of AAV Tropism | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30DK026743 | UCSF Liver Center | 5 | 2025 |
| P01CA019014 | Viral Oncogenesis, Latency, and Replication | 4 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 4 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 4 | 2025 |
| R01AR046713 | Cytokine regulation of RA synoviocyte phenotype | 4 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,236Source NIH's project files
See all 1,236 nih grantsPapers1,911
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Author Correction: Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation. | Nat Immunol | 2026 | 42773268 | PubTator, text mining | PubMed |
| CRISPR/Cas9 screening revealed BIRC6-AS1/BIRC6 mediates abiraterone resistance via NHEJ pathway-dependent A20 degradation in prostate cancer. | Oncogene | 2026 | 42754663 | PubTator, text mining | PubMed |
| Editorial comment on "Functional changes in the gut microbiota are associated with the intestinal phenotype in A20 haploinsufficiency". | Pediatr Allergy Immunol | 2026 | 42747403 | PubTator, text mining | PubMed |
| In-depth examination of the zinc-mitigation of the molecular effects of heat stress-induced intestinal damage in broilers. | Poult Sci | 2026 | 42731220 | PubTator, text mining | PubMed |
| Glucose hypometabolism gates tau-dependent necroptosis. | Neuron | 2026 | 42685677 | PubTator, text mining | PubMed |
| Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-κB. | JCI Insight | 2026 | 42579371 | PubTator, text mining | PubMed |
| Compartment-specific Zinc Misallocation in Diabetic Foot Ulcers: Mechanistic Coupling Between Macrophage M1 Locking and MMP-9 Hyperactivation. | Biol Trace Elem Res | 2026 | 42448958 | PubTator, text mining | PubMed |
| Cryptic RNA binding sites are energetically accessible and chemically addressable. | bioRxiv | 2026 | 42427657 | PubTator, text mining | PubMed |
| Behçet's spectrum disorders: genetic and immunological insights into an emerging disease concept. | World J Pediatr | 2026 | 42337193 | PubTator, text mining | PubMed |
| The host ubiquitination system dynamically regulates the inflammatory response of macrophages to bacteria. | Front Immunol | 2026 | 42199436 | PubTator, text mining | PubMed |
1 to 10 of 1,911
See all 1,911 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
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