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Gene · 28996

HIPK2: homeodomain interacting protein kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HIPK2: homeodomain interacting protein kinase 2. Genes, record 28996. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/28996

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Gene

Symbol
HIPK2
HGNC
Name
homeodomain interacting protein kinase 2
HGNC
NCBI Gene ID
28996
NCBI Gene
HGNC ID
HGNC:14402
HGNC
Ensembl
ENSG00000064393
NCBI Gene
Aliases
PRO0593
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H2X6Homeodomain-interacting protein kinase 21,1982Ensembl, GeneID, HGNC

Source UniProt

Patents14

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1449345Q9H2X6Espacenet
EP 4641201 A22025-10-2912776Q9H2X6Espacenet
JP 2025529142 A2025-09-041954Q9H2X6Espacenet
US 12371689 B22025-07-291954Q9H2X6Espacenet
JP 2025517969 A2025-06-1212776Q9H2X6Espacenet
US 11446398 B22022-09-2038885Q9H2X6Espacenet
JP 2022524081 A2022-04-27141856Q9H2X6Espacenet
JP 2019054813 A2019-04-11229780Q9H2X6Espacenet
JP 2017121241 A2017-07-13229780Q9H2X6Espacenet
JP 2015516143 A2015-06-08229780Q9H2X6Espacenet

1 to 10 of 14

See all 14 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants997

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHIPK2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant62025
P30CA008748Cancer Center Support Grant42025
P40OD010440Caenorhabditis Genetics Center42025
P01CA108671Myeloproliferative Neoplasms-Research Consortium32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025
P30CA043703Case Comprehensive Cancer Center Support Grant32025
P40OD018537Bloomington Drosophila Stock Center at Indiana University32025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant22025
P30CA021765Cancer Center Support Grant (CCSG)22025

1 to 10 of 997Source NIH's project files

See all 997 nih grants

Papers1,691

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exosomal hnRNPA1-delivered miR-27a-3p inhibits the radiation-induced bystander effect in cervical cancer.Precis Radiat Oncol202642609938PubTator, text miningPubMed
Phosphorylation dynamics of sodium-independent organic anion transporter SLCO4A1 and its role in diseases: a review.Front Syst Biol202642601857PubTator, text miningPubMed
The Role of KLF4 in Lps-Induced Intestinal Epithelial Cell Injury Through the MIR-1306-5P/HIPK2 Signaling Axis.Shock202642584980PubTator, text miningPubMed
HIPK2 exhibits context dependent dualistic effects and combinatorial inhibition of HIPK2-NLK-MAPK11 axis manifests synergism against gastric cancer.Hum Cell202642547687PubTator, text miningPubMed
Downregulated HIPK2 Expression in T Cells Is Associated with Occult Hepatitis B Virus Infection.Microorganisms202642514028PubTator, text miningPubMed
Factors Determining Sirtuin-1 Target Engagement.Adv Biol (Weinh)202642500827PubTator, text miningPubMed
Activation of the TGF-β1/HIPK2 signaling pathway exacerbates EMT injury in renal tubular epithelial cells in diabetic kidney disease.Ren Fail202642476945PubTator, text miningPubMed
USP2 mediates HDAC6-dependent stabilization of HIPK2 and enhances its proapoptotic function.Biochem Biophys Res Commun202642468180PubTator, text miningPubMed
Retraction of the Research Article "IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion".Sci Signal202642447214PubTator, text miningPubMed
Integrated transcriptomic analysis reveals key regulatory mechanisms of HIPK2 in osteoarthritis and identifies potential therapeutic target drugs.Medicine (Baltimore)202642363474PubTator, text miningPubMed

1 to 10 of 1,691

See all 1,691 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/28996

GET https://conductscience.org/api/genes/v1/28996/patents