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GRIN1: glutamate ionotropic receptor NMDA type subunit 1

1 protein, 48 patents, 33 drugs, 850 trials, 4,116 NIH grants and 6,432 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGRIN1HGNC
Nameglutamate ionotropic receptor NMDA type subunit 1HGNC
NCBI Gene ID2902NCBI Gene
HGNC IDHGNC:4584HGNC
EnsemblENSG00000176884NCBI Gene
AliasesDEE101, GluN1, MRD8, NDHMSD, NDHMSR, NMD-R1, NMDA1, NMDAR1, NR1, hNR1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q05586Glutamate receptor ionotropic, NMDA 193884Ensembl, GeneID, HGNCUniProt

Patents 48

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026519320 A2026-06-166Q05586Espacenet
EP 4689655 A12026-02-116Q05586Espacenet
JP 2026004568 A2026-01-1447771Q05586Espacenet
EP 4650780 A22025-11-198969Q05586Espacenet
EP 4641201 A22025-10-299225Q05586Espacenet
JP 2025529142 A2025-09-041874Q05586Espacenet
US 12371689 B22025-07-291874Q05586Espacenet
JP 2025517969 A2025-06-129225Q05586Espacenet
JP 2025517970 A2025-06-128969Q05586Espacenet
EP 4551941 A22025-05-1420Q05586Espacenet

Drugs 33

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACAMPROSATECHEMBL1201293Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AMANTADINECHEMBL660Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AMANTADINE HYDROCHLORIDECHEMBL1569Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
APIMOSTINELCHEMBL3989872Glutamate [NMDA] receptor partial agonistPARTIAL AGONISTChEMBL
AV-101CHEMBL3545351Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AZD8108CHEMBL3707355Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
CNS-5161CHEMBL41306Glutamate [NMDA] receptor blockerBLOCKERChEMBL
DELUCEMINECHEMBL2110814Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
ESKETAMINECHEMBL395091Glutamate [NMDA] receptor negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL

Trials 850

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603596ESKETAMINEPHASE1ClinicalTrials.gov
NCT07602153ESKETAMINEClinicalTrials.gov
NCT07597486ESKETAMINEClinicalTrials.gov
NCT07584902ESKETAMINEClinicalTrials.gov
NCT07573969KETAMINEPHASE3ClinicalTrials.gov
NCT07569198KETAMINEPHASE2ClinicalTrials.gov
NCT07564531KETAMINEClinicalTrials.gov
NCT07563296KETAMINEPHASE2ClinicalTrials.gov
NCT07560878MEMANTINEEARLY_PHASE1ClinicalTrials.gov
NCT07560722ESKETAMINEClinicalTrials.gov

NIH grants 4116

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HD082373NMDAR Mutations & Neurodevelopmental Disorder: from Mechanism to Targeted Therapy342,025NIH's project files
R35NS111619Glutamate receptors and human neurological disease302,025NIH's project files
R01MH085926Structures and reagents of NMDA receptors242,025NIH's project files
R01NS097536Structural and functional investigation of allosteric NMDA receptor modulation242,025NIH's project files
R28AA012725Brain Tissue Resource Center for Alcohol Research172,025NIH's project files
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect142,025NIH's project files
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders122,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award112,025NIH's project files
P50AA012870Center for the Translational Neuroscience of Alcoholism82,025NIH's project files
ZIANS002994Subunit-Specific Regulation Of Glutamate Receptors82,025NIH's project files

Papers 6432

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819978PubTator, text miningPubMed
42792781PubTator, text miningPubMed
42785993PubTator, text miningPubMed
42711907PubTator, text miningPubMed
42711406PubTator, text miningPubMed
42704075PubTator, text miningPubMed
42681313PubTator, text miningPubMed
42665662PubTator, text miningPubMed
42650812PubTator, text miningPubMed
42609620PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license