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GRIN2B: glutamate ionotropic receptor NMDA type subunit 2B

1 protein, 41 patents, 33 drugs, 850 trials, 4,673 NIH grants and 7,195 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGRIN2BHGNC
Nameglutamate ionotropic receptor NMDA type subunit 2BHGNC
NCBI Gene ID2904NCBI Gene
HGNC IDHGNC:4586HGNC
EnsemblENSG00000273079NCBI Gene
AliasesDEE27, EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13224Glutamate receptor ionotropic, NMDA 2B1,48436Ensembl, GeneID, HGNCUniProt

Patents 41

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447777Q13224Espacenet
EP 4641201 A22025-10-2922644Q13224Espacenet
JP 2025147176 A2025-10-066235Q13224Espacenet
JP 2025529142 A2025-09-041876Q13224Espacenet
JP 2025529142 A2025-09-046547Q13224Espacenet
US 12371689 B22025-07-291876Q13224Espacenet
US 12371689 B22025-07-296547Q13224Espacenet
JP 2025094198 A2025-06-2448Q13224Espacenet
JP 2025517969 A2025-06-1222644Q13224Espacenet
EP 4551941 A22025-05-1422Q13224Espacenet

Drugs 33

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACAMPROSATECHEMBL1201293Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AMANTADINECHEMBL660Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AMANTADINE HYDROCHLORIDECHEMBL1569Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
APIMOSTINELCHEMBL3989872Glutamate [NMDA] receptor partial agonistPARTIAL AGONISTChEMBL
AV-101CHEMBL3545351Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AZD8108CHEMBL3707355Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
CNS-5161CHEMBL41306Glutamate [NMDA] receptor blockerBLOCKERChEMBL
DELUCEMINECHEMBL2110814Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
ESKETAMINECHEMBL395091Glutamate [NMDA] receptor negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL

Trials 850

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603596ESKETAMINEPHASE1ClinicalTrials.gov
NCT07602153ESKETAMINEClinicalTrials.gov
NCT07597486ESKETAMINEClinicalTrials.gov
NCT07584902ESKETAMINEClinicalTrials.gov
NCT07573969KETAMINEPHASE3ClinicalTrials.gov
NCT07569198KETAMINEPHASE2ClinicalTrials.gov
NCT07564531KETAMINEClinicalTrials.gov
NCT07563296KETAMINEPHASE2ClinicalTrials.gov
NCT07560878MEMANTINEEARLY_PHASE1ClinicalTrials.gov
NCT07560722ESKETAMINEClinicalTrials.gov

NIH grants 4673

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HD082373NMDAR Mutations & Neurodevelopmental Disorder: from Mechanism to Targeted Therapy302,025NIH's project files
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect262,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award252,025NIH's project files
R35NS111619Glutamate receptors and human neurological disease242,025NIH's project files
R01MH085926Structures and reagents of NMDA receptors202,025NIH's project files
R01MH101221Rare Mutations and Autism Spectrum Disorders192,025NIH's project files
P50AA012870Center for the Translational Neuroscience of Alcoholism182,025NIH's project files
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders182,025NIH's project files
P01AI073693Anti-NMDA Receptor Antibodies in Adult Brain Dysfunction: Lessons from Lupus162,025NIH's project files
R01NS081248CaMKII Holoenzyme Mechanisms in Opposing Forms of Synaptic Plasticity162,025NIH's project files

Papers 7195

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42777704PubTator, text miningPubMed
42741404PubTator, text miningPubMed
42716376PubTator, text miningPubMed
42701110PubTator, text miningPubMed
42693859PubTator, text miningPubMed
42681313PubTator, text miningPubMed
42670051PubTator, text miningPubMed
42647276PubTator, text miningPubMed
42634203PubTator, text miningPubMed
42628984PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license