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Gene · 2905

GRIN2C: glutamate ionotropic receptor NMDA type subunit 2C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GRIN2C: glutamate ionotropic receptor NMDA type subunit 2C. Genes, record 2905. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2905

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Gene

Symbol
GRIN2C
HGNC
Name
glutamate ionotropic receptor NMDA type subunit 2C
HGNC
NCBI Gene ID
2905
NCBI Gene
HGNC ID
HGNC:4587
HGNC
Ensembl
ENSG00000161509
NCBI Gene
Aliases
GluN2C, NMDAR2C, NR2C
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14957Glutamate receptor ionotropic, NMDA 2C1,2336Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447778Q14957Espacenet
EP 4650780 A22025-11-193518Q14957Espacenet
EP 4641201 A22025-10-293099Q14957Espacenet
JP 2025529142 A2025-09-041877Q14957Espacenet
US 12371689 B22025-07-291877Q14957Espacenet
JP 2025094198 A2025-06-2433Q14957Espacenet
JP 2025517969 A2025-06-123099Q14957Espacenet
JP 2025517970 A2025-06-123518Q14957Espacenet
EP 4551941 A22025-05-1423Q14957Espacenet
JP 2025032204 A2025-03-1129356Q14957Espacenet

1 to 10 of 33

See all 33 patents

Drugs28

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACAMPROSATECHEMBL1201293Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
ACAMPROSATE CALCIUMCHEMBL2068724Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AMANTADINECHEMBL660Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AMANTADINE HYDROCHLORIDECHEMBL1569Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
APIMOSTINELCHEMBL3989872Glutamate [NMDA] receptor partial agonistPARTIAL AGONISTChEMBL
AV-101CHEMBL3545351Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
AZD8108CHEMBL3707355Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
CNS-5161CHEMBL41306Glutamate [NMDA] receptor blockerBLOCKERChEMBL
DELUCEMINECHEMBL2110814Glutamate [NMDA] receptor antagonistANTAGONISTChEMBL
ESKETAMINECHEMBL395091Glutamate [NMDA] receptor negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL

1 to 10 of 28

See all 28 drugs

Trials838

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants885

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGRIN2C papersNewest fiscal year
R01HD082373NMDAR Mutations & Neurodevelopmental Disorder: from Mechanism to Targeted Therapy202025
R35NS111619Glutamate receptors and human neurological disease142025
R01NS097536Structural and functional investigation of allosteric NMDA receptor modulation82025
R28AA012725Brain Tissue Resource Center for Alcohol Research82025
R01MH085926Structures and reagents of NMDA receptors52025
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect52025
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders52025
P50AA012870Center for the Translational Neuroscience of Alcoholism42025
R01AG075444Subtype-selective NMDA ligands for Alzheimer's Disease42025
T32ES012870Graduate and Postdoctoral Training in Environmental Health Science and Toxicology42025

1 to 10 of 885Source NIH's project files

See all 885 nih grants

Papers965

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Neuronal Grin2c expression and the cocaine engram: a medial prefrontal cortex substrate for conditioned place preference.bioRxiv202642818582PubTator, text miningPubMed
DNA Methylation at Core N-Methyl-D-Aspartate (NMDA) Receptor Genes Reveals a Glutamatergic Signature of Aging in Post-COVID Whole Blood With Implications for Long-COVID Neuropsychiatric Sequelae.Cureus202642471918PubTator, text miningPubMed
NMDA Receptor-Targeted Neuroprotection in Ischemic Stroke: The 3S Framework Integrating Spatiotemporal Dynamics, Subtype Selectivity, and Signaling Pathways.Curr Neuropharmacol202642337875PubTator, text miningPubMed
Integrating machine learning and retrospective cohort to explore the effects of AEDs on the prognosis of LGG and identify related molecular targets.BMC Pharmacol Toxicol202642298735PubTator, text miningPubMed
Network pharmacology and molecular docking of arctic Pseudogymnoascus australis compounds targeting ionotropic glutamate receptors for neuroprotection.Comput Biol Chem202642160907PubTator, text miningPubMed
Resting-state EEG alpha-BOLD coupling spatially follows cortical cell-type and receptor gradients.bioRxiv202642039434PubTator, text miningPubMed
Magnesium Transporter SLC41A1 Links Magnesium Homeostasis to NMDA Receptor-Related Synaptic Dysfunction: A Transdiagnostic Therapeutic Target for Neuropsychiatric Disorders.Biomedicines202641898257PubTator, text miningPubMed
Association Between GRIN1 rs28489906 and Major Depressive Disorder and Treatment Response to Antidepressants in Patients with Type 2 Diabetes.Brain Sci202641892611PubTator, text miningPubMed
Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes.Clin Rev Allergy Immunol202641854785PubTator, text miningPubMed
Serum proteomic characterization of stump-tailed macaques (Macaca arctoides) with neutralizing antibodies against Dengue virus in Thailand.PLoS One202641729959PubTator, text miningPubMed

1 to 10 of 965

See all 965 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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