Gene · 2906
GRIN2D: glutamate ionotropic receptor NMDA type subunit 2D
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GRIN2D: glutamate ionotropic receptor NMDA type subunit 2D. Genes, record 2906. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2906
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15399 | Glutamate receptor ionotropic, NMDA 2D | 1,336 | 13 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47780 | O15399 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2186 | O15399 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1878 | O15399 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1878 | O15399 | Espacenet |
| JP 2025094198 A | 2025-06-24 | 38 | O15399 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2186 | O15399 | Espacenet |
| EP 4551941 A2 | 2025-05-14 | 24 | O15399 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 29358 | O15399 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 29358 | O15399 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 29358 | O15399 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs28
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ACAMPROSATE | CHEMBL1201293 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| ACAMPROSATE CALCIUM | CHEMBL2068724 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| AMANTADINE | CHEMBL660 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| AMANTADINE HYDROCHLORIDE | CHEMBL1569 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| APIMOSTINEL | CHEMBL3989872 | Glutamate [NMDA] receptor partial agonist | PARTIAL AGONIST | ChEMBL |
| AV-101 | CHEMBL3545351 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| AZD8108 | CHEMBL3707355 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| CNS-5161 | CHEMBL41306 | Glutamate [NMDA] receptor blocker | BLOCKER | ChEMBL |
| DELUCEMINE | CHEMBL2110814 | Glutamate [NMDA] receptor antagonist | ANTAGONIST | ChEMBL |
| ESKETAMINE | CHEMBL395091 | Glutamate [NMDA] receptor negative allosteric modulator | NEGATIVE ALLOSTERIC MODULATOR | ChEMBL |
1 to 10 of 28
See all 28 drugsTrials838
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07603596 | ESKETAMINE | PHASE1 | ClinicalTrials.gov | |
| NCT07602153 | ESKETAMINE | ClinicalTrials.gov | ||
| NCT07597486 | ESKETAMINE | ClinicalTrials.gov | ||
| NCT07584902 | ESKETAMINE | ClinicalTrials.gov | ||
| NCT07573969 | KETAMINE | PHASE3 | ClinicalTrials.gov | |
| NCT07569198 | KETAMINE | PHASE2 | ClinicalTrials.gov | |
| NCT07564531 | KETAMINE | ClinicalTrials.gov | ||
| NCT07563296 | KETAMINE | PHASE2 | ClinicalTrials.gov | |
| NCT07560878 | MEMANTINE | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07560722 | ESKETAMINE | ClinicalTrials.gov |
1 to 10 of 838
See all 838 trialsNIH grants899
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GRIN2D papers | Newest fiscal year |
|---|---|---|---|
| R01HD082373 | NMDAR Mutations & Neurodevelopmental Disorder: from Mechanism to Targeted Therapy | 25 | 2025 |
| R35NS111619 | Glutamate receptors and human neurological disease | 20 | 2025 |
| R01NS097536 | Structural and functional investigation of allosteric NMDA receptor modulation | 8 | 2025 |
| R01MH085926 | Structures and reagents of NMDA receptors | 7 | 2025 |
| ZIAMH002857 | Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect | 7 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 5 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 5 | 2025 |
| T32ES012870 | Graduate and Postdoctoral Training in Environmental Health Science and Toxicology | 5 | 2025 |
| ZIAMH002927 | Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders | 5 | 2025 |
| R01AG075444 | Subtype-selective NMDA ligands for Alzheimer's Disease | 4 | 2025 |
1 to 10 of 899Source NIH's project files
See all 899 nih grantsPapers1,100
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Corrigendum to "CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer" [Pharmacol. Res. 202 (2024) 107127]. | Pharmacol Res | 2026 | 42805841 | PubTator, text mining | PubMed |
| Construction of molecular signatures based on the co-expression network of NECSO-related gene TRPM4 and its prognostic value in hepatocellular carcinoma. | J Gastrointest Oncol | 2026 | 42703320 | PubTator, text mining | PubMed |
| GRIN-related epilepsy in Chinese pediatric patients: a retrospective study of clinical, genetic, and mutant protein structural features in a tertiary center cohort. | World J Pediatr | 2026 | 42681313 | PubTator, text mining | PubMed |
| DNA Methylation at Core N-Methyl-D-Aspartate (NMDA) Receptor Genes Reveals a Glutamatergic Signature of Aging in Post-COVID Whole Blood With Implications for Long-COVID Neuropsychiatric Sequelae. | Cureus | 2026 | 42471918 | PubTator, text mining | PubMed |
| GluN2D-containing NMDA receptors support dentate granule cell excitability, synaptic plasticity, and memory. | bioRxiv | 2026 | 42427625 | PubTator, text mining | PubMed |
| NMDA Receptor-Targeted Neuroprotection in Ischemic Stroke: The 3S Framework Integrating Spatiotemporal Dynamics, Subtype Selectivity, and Signaling Pathways. | Curr Neuropharmacol | 2026 | 42337875 | PubTator, text mining | PubMed |
| Expression and Localization of NMDA Receptor GluN2 Subunits in Dorsal Horn Pain Circuits across Sex, Species, and Late Postnatal Development. | J Neurosci | 2026 | 42167918 | PubTator, text mining | PubMed |
| Association Between GRIN1 rs28489906 and Major Depressive Disorder and Treatment Response to Antidepressants in Patients with Type 2 Diabetes. | Brain Sci | 2026 | 41892611 | PubTator, text mining | PubMed |
| Paradoxical Expression of Ionotropic Glutamate Receptors in Leucocytes. | Clin Rev Allergy Immunol | 2026 | 41854785 | PubTator, text mining | PubMed |
| GluN2D NMDA Receptors: Bridging Physiology and Pathology. | Biol Psychiatry | 2026 | 41765344 | PubTator, text mining | PubMed |
1 to 10 of 1,100
See all 1,100 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/2906
GET https://conductscience.org/api/genes/v1/2906/patents?page=2