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NR3C1: nuclear receptor subfamily 3 group C member 1

1 protein, 221 patents, 82 drugs, 7,990 trials, 11,825 NIH grants and 24,397 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNR3C1HGNC
Namenuclear receptor subfamily 3 group C member 1HGNC
NCBI Gene ID2908NCBI Gene
HGNC IDHGNC:7978HGNC
EnsemblENSG00000113580NCBI Gene
AliasesGCCR, GCR, GCRST, GR, GRLNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04150Glucocorticoid receptor77758Ensembl, GeneID, HGNCUniProt

Patents 221

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086503 A2026-05-2676P04150Espacenet
US 12624353 B22026-05-12498P04150Espacenet
US 12624354 B22026-05-12498P04150Espacenet
JP 2026062659 A2026-04-10498P04150Espacenet
US 12570972 B22026-03-10498P04150Espacenet
EP 4683650 A22026-01-28459P04150Espacenet
US 12509680 B22025-12-30498P04150Espacenet
EP 4650780 A22025-11-196791P04150Espacenet
EP 4641201 A22025-10-296587P04150Espacenet
WO 2025215156 A12025-10-161P04150Espacenet

Drugs 82

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABBV-3373CHEMBL4297572Glucocorticoid receptor modulatorMODULATORChEMBL
ALCLOMETASONE DIPROPIONATECHEMBL1200989Glucocorticoid receptor agonistAGONISTChEMBL
AMCINONIDECHEMBL1200732Glucocorticoid receptor agonistAGONISTChEMBL
AZD-5423CHEMBL4072756Glucocorticoid receptor modulatorMODULATORChEMBL
BECLOMETHASONE DIPROPIONATECHEMBL1200500Glucocorticoid receptor agonistAGONISTChEMBL
BETAMETHASONECHEMBL632Glucocorticoid receptor agonistAGONISTChEMBL
BETAMETHASONE ACETATECHEMBL1200538Glucocorticoid receptor agonistAGONISTChEMBL
BETAMETHASONE BENZOATECHEMBL1200376Glucocorticoid receptor agonistAGONISTChEMBL
BETAMETHASONE DIPROPIONATECHEMBL1200384Glucocorticoid receptor agonistAGONISTChEMBL
BETAMETHASONE PHOSPHORIC ACIDCHEMBL1201207Glucocorticoid receptor agonistAGONISTChEMBL

Trials 7990

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07606391TRIAMCINOLONE ACETONIDEClinicalTrials.gov
NCT07605416DEXAMETHASONEPHASE2ClinicalTrials.gov
NCT07604987DEXAMETHASONEPHASE2ClinicalTrials.gov
NCT07601100DEXAMETHASONEPHASE1/PHASE2ClinicalTrials.gov
NCT07600151DEXAMETHASONEPHASE1/PHASE2ClinicalTrials.gov
NCT07597473FLUTICASONE PROPIONATEPHASE4ClinicalTrials.gov
NCT07596628TRIAMCINOLONEPHASE2ClinicalTrials.gov
NCT07595796BUDESONIDEClinicalTrials.gov
NCT07594912METHYLPREDNISOLONEPHASE2ClinicalTrials.gov
NCT07588698PREDNISOLONEPHASE2ClinicalTrials.gov

NIH grants 11825

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIAES090057Glucocorticoid Hormone Action652,025NIH's project files
P30CA008748Cancer Center Support Grant642,025NIH's project files
ZIABC005450Chromatin Structure and Gene Expression482,025NIH's project files
P30CA016672Cancer Center Support Grant462,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)422,025NIH's project files
ZIAES071006Epigenetic and Transcriptional Functions of Nuclear Receptors and Chromatin Remodeling Proteins in Stem and Cancer Cells312,025NIH's project files
P50CA097186The Pacific Northwest Prostate Cancer SPORE302,025NIH's project files
P30CA014599Cancer Center Support Grant282,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology262,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award262,025NIH's project files

Papers 24397

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823066PubTator, text miningPubMed
42821363PubTator, text miningPubMed
42818338PubTator, text miningPubMed
42818321PubTator, text miningPubMed
42815874PubTator, text miningPubMed
42802518PubTator, text miningPubMed
42799643PubTator, text miningPubMed
42799270PubTator, text miningPubMed
42792815PubTator, text miningPubMed
42782744PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license