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Gene · 29128

UHRF1: ubiquitin like with PHD and ring finger domains 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. UHRF1: ubiquitin like with PHD and ring finger domains 1. Genes, record 29128. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/29128

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Gene

Symbol
UHRF1
HGNC
Name
ubiquitin like with PHD and ring finger domains 1
HGNC
NCBI Gene ID
29128
NCBI Gene
HGNC ID
HGNC:12556
HGNC
Ensembl
ENSG00000276043
NCBI Gene
Aliases
FLJ21925, ICBP90, Np95, RNF106, TDRD22, hNP95, hUHRF1, huNp95
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96T88E3 ubiquitin-protein ligase UHRF179345Ensembl, GeneID, HGNC

Source UniProt

Patents46

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1918322Q96T88Espacenet
EP 4641202 A22025-10-299390Q96T88Espacenet
JP 2025517970 A2025-06-1218322Q96T88Espacenet
KR 1020250017231 A2025-02-049390Q96T88Espacenet
US 11446398 B22022-09-2095356Q96T88Espacenet
US 11446398 B22022-09-2095357Q96T88Espacenet
US 11446398 B22022-09-2095360Q96T88Espacenet
US 11446398 B22022-09-2095361Q96T88Espacenet
JP 2022092366 A2022-06-22743Q96T88Espacenet
JP 2022524081 A2022-04-27198327Q96T88Espacenet

1 to 10 of 46

See all 46 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,503

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUHRF1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant122025
P30CA008748Cancer Center Support Grant112025
P30CA016086Cancer Center Support Grant92025
P30CA021765Cancer Center Support Grant (CCSG)82025
R01DK080789Regulation of Liver Regeneration by UHRF162025
P30CA006973Regional Oncology Research Center52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
R35GM134744Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms52025
P30CA043703Case Comprehensive Cancer Center Support Grant42025

1 to 10 of 1,503Source NIH's project files

See all 1,503 nih grants

Papers2,616

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A feed-forward UHRF1 read-write mechanism supports H3 multi- mono-ubiquitination and DNA methylation maintenance at CpG-sparse regions.bioRxiv202642818397PubTator, text miningPubMed
USP4-Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC.Adv Sci (Weinh)202642811544PubTator, text miningPubMed
Aurora kinase a phosphorylates and stabilizes UHRF1 to maintain DNA methylation and prostate cancer cell survival.Epigenetics202642789740PubTator, text miningPubMed
Linking HLA class II susceptibility to HSPC transcriptomics and antigen presentation in aplastic anemia.Front Immunol202642774213PubTator, text miningPubMed
Exacerbation of renal interstitial fibrosis by the UHRF1/G9a axis through epigenetic silencing of KLF15.Ren Fail202642768892PubTator, text miningPubMed
[Corrigendum] TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex.Int J Oncol202642757459PubTator, text miningPubMed
Biomolecular Condensates Integrate Transcriptional and Epigenetic Responses to Hypoxia.Int J Mol Sci202642737822PubTator, text miningPubMed
TIP60-mediated acetylation of UHRF1 is associated with tumor cell-dependent M2-like macrophage phenotypes and aggressiveness in gastric cardia adenocarcinoma.Biochim Biophys Acta Mol Basis Dis202642722134PubTator, text miningPubMed
Extracellular chromatin fragments as biomarkers for cancer screening.Semin Cancer Biol202642692176PubTator, text miningPubMed
(+)-Catechin:lysine 1:2 promotes HIV-1 quiescence through a biphasic and dose-dependent mechanism: Implications for block-and-lock cure strategies.Biomed Pharmacother202642685495PubTator, text miningPubMed

1 to 10 of 2,616

See all 2,616 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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