Gene · 29128
UHRF1: ubiquitin like with PHD and ring finger domains 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. UHRF1: ubiquitin like with PHD and ring finger domains 1. Genes, record 29128. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/29128
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96T88 | E3 ubiquitin-protein ligase UHRF1 | 793 | 45 | Ensembl, GeneID, HGNC |
Source UniProt
Patents46
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 18322 | Q96T88 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 9390 | Q96T88 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 18322 | Q96T88 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 9390 | Q96T88 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 95356 | Q96T88 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 95357 | Q96T88 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 95360 | Q96T88 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 95361 | Q96T88 | Espacenet |
| JP 2022092366 A | 2022-06-22 | 743 | Q96T88 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 198327 | Q96T88 | Espacenet |
1 to 10 of 46
See all 46 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,503
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | UHRF1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 12 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 9 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 8 | 2025 |
| R01DK080789 | Regulation of Liver Regeneration by UHRF1 | 6 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 5 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 5 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 5 | 2025 |
| R35GM134744 | Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms | 5 | 2025 |
| P30CA043703 | Case Comprehensive Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,503Source NIH's project files
See all 1,503 nih grantsPapers2,616
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A feed-forward UHRF1 read-write mechanism supports H3 multi- mono-ubiquitination and DNA methylation maintenance at CpG-sparse regions. | bioRxiv | 2026 | 42818397 | PubTator, text mining | PubMed |
| USP4-Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC. | Adv Sci (Weinh) | 2026 | 42811544 | PubTator, text mining | PubMed |
| Aurora kinase a phosphorylates and stabilizes UHRF1 to maintain DNA methylation and prostate cancer cell survival. | Epigenetics | 2026 | 42789740 | PubTator, text mining | PubMed |
| Linking HLA class II susceptibility to HSPC transcriptomics and antigen presentation in aplastic anemia. | Front Immunol | 2026 | 42774213 | PubTator, text mining | PubMed |
| Exacerbation of renal interstitial fibrosis by the UHRF1/G9a axis through epigenetic silencing of KLF15. | Ren Fail | 2026 | 42768892 | PubTator, text mining | PubMed |
| [Corrigendum] TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex. | Int J Oncol | 2026 | 42757459 | PubTator, text mining | PubMed |
| Biomolecular Condensates Integrate Transcriptional and Epigenetic Responses to Hypoxia. | Int J Mol Sci | 2026 | 42737822 | PubTator, text mining | PubMed |
| TIP60-mediated acetylation of UHRF1 is associated with tumor cell-dependent M2-like macrophage phenotypes and aggressiveness in gastric cardia adenocarcinoma. | Biochim Biophys Acta Mol Basis Dis | 2026 | 42722134 | PubTator, text mining | PubMed |
| Extracellular chromatin fragments as biomarkers for cancer screening. | Semin Cancer Biol | 2026 | 42692176 | PubTator, text mining | PubMed |
| (+)-Catechin:lysine 1:2 promotes HIV-1 quiescence through a biphasic and dose-dependent mechanism: Implications for block-and-lock cure strategies. | Biomed Pharmacother | 2026 | 42685495 | PubTator, text mining | PubMed |
1 to 10 of 2,616
See all 2,616 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/29128
GET https://conductscience.org/api/genes/v1/29128/patents?page=2