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GRM5: glutamate metabotropic receptor 5

1 protein, 48 patents, 9 drugs, 36 trials, 3,228 NIH grants and 4,739 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGRM5HGNC
Nameglutamate metabotropic receptor 5HGNC
NCBI Gene ID2915NCBI Gene
HGNC IDHGNC:4597HGNC
EnsemblENSG00000168959NCBI Gene
AliasesGPRC1E, MGLUR5, PPP1R86, mGlu5NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P41594Metabotropic glutamate receptor 51,21229Ensembl, GeneID, HGNCUniProt

Patents 48

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194402P41594Espacenet
EP 4641201 A22025-10-293946P41594Espacenet
JP 2025147176 A2025-10-066245P41594Espacenet
JP 2025529142 A2025-09-041886P41594Espacenet
JP 2025529142 A2025-09-046550P41594Espacenet
US 12371689 B22025-07-291886P41594Espacenet
US 12371689 B22025-07-296550P41594Espacenet
JP 2025517969 A2025-06-123946P41594Espacenet
JP 2025517970 A2025-06-124402P41594Espacenet
EP 4541896 A12025-04-23269P41594Espacenet

Drugs 9

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD2066CHEMBL3545164Metabotropic glutamate receptor 5 modulatorMODULATORChEMBL
AZD2516CHEMBL3545346Metabotropic glutamate receptor 5 negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
BASIMGLURANTCHEMBL3301626Metabotropic glutamate receptor 5 modulatorMODULATORChEMBL
DASOLAMPANEL ETIBUTILCHEMBL2107328Metabotropic glutamate receptor 5 antagonistANTAGONISTChEMBL
DIPRAGLURANTCHEMBL2346738Metabotropic glutamate receptor 5 modulatorMODULATORChEMBL
MAVOGLURANTCHEMBL3087515Metabotropic glutamate receptor 5 antagonistANTAGONISTChEMBL
RASEGLURANTCHEMBL3545036Metabotropic glutamate receptor 5 modulatorMODULATORChEMBL
RG7342CHEMBL3545203Metabotropic glutamate receptor 5 modulatorMODULATORChEMBL
STX107CHEMBL3642985Metabotropic glutamate receptor 5 negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL

Trials 36

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05217628BASIMGLURANTPHASE2/PHASE3ClinicalTrials.gov
NCT05116813DIPRAGLURANTPHASE2/PHASE3ClinicalTrials.gov
NCT05059327BASIMGLURANTPHASE2ClinicalTrials.gov
NCT05027997DIPRAGLURANTPHASE2ClinicalTrials.gov
NCT04857359DIPRAGLURANTPHASE2/PHASE3ClinicalTrials.gov
NCT04771143MAVOGLURANTPHASE1ClinicalTrials.gov
NCT03242928MAVOGLURANTPHASE22021-02-04ClinicalTrials.gov
NCT02920892MAVOGLURANTPHASE22023-10-10ClinicalTrials.gov
NCT02433093BASIMGLURANTPHASE1ClinicalTrials.gov
NCT01813019MAVOGLURANTPHASE22016-07-21ClinicalTrials.gov

NIH grants 3228

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01MH062646Regulation of Signaling by mGluR5772,025NIH's project files
R01NS031373Functions of Metabotropic Glutamate Receptor Subtypes752,025NIH's project files
R01HD036071Genotype-Phenotype Relationships in Fragile X Families312,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award222,025NIH's project files
ZIAMH002793PET Radiopharmaceutical Sciences182,025NIH's project files
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect172,025NIH's project files
P50AA012870Center for the Translational Neuroscience of Alcoholism152,025NIH's project files
R01AG034924mGluR5 and Phase State Dependent Synaptic Loss in Alzheimer's Disease122,025NIH's project files
T32MH065215Postdoctoral Program in Functional Neurogenomics122,025NIH's project files
ZIAMH002852Clinical Evaluation of PET Radiotracers102,025NIH's project files

Papers 4739

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816386PubTator, text miningPubMed
42797421PubTator, text miningPubMed
42781272PubTator, text miningPubMed
42776830PubTator, text miningPubMed
42755892PubTator, text miningPubMed
42729732PubTator, text miningPubMed
42716522PubTator, text miningPubMed
42699832PubTator, text miningPubMed
42690719PubTator, text miningPubMed
42687141PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license