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Gene · 2917

GRM7: glutamate metabotropic receptor 7

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GRM7: glutamate metabotropic receptor 7. Genes, record 2917. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2917

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Gene

Symbol
GRM7
HGNC
Name
glutamate metabotropic receptor 7
HGNC
NCBI Gene ID
2917
NCBI Gene
HGNC ID
HGNC:4599
HGNC
Ensembl
ENSG00000196277
NCBI Gene
Aliases
GLUR7, GPRC1G, MGLU7, MGLUR7, NEDSHBA, PPP1R87, mGlu7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14831Metabotropic glutamate receptor 79156Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447811Q14831Espacenet
EP 4650780 A22025-11-197470Q14831Espacenet
EP 4640849 A22025-10-291113Q14831Espacenet
EP 4641201 A22025-10-297443Q14831Espacenet
JP 2025529142 A2025-09-041888Q14831Espacenet
US 12371689 B22025-07-291888Q14831Espacenet
JP 2025519096 A2025-06-241113Q14831Espacenet
JP 2025517969 A2025-06-127443Q14831Espacenet
JP 2025517970 A2025-06-127470Q14831Espacenet
JP 2025032204 A2025-03-1129404Q14831Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,231

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGRM7 papersNewest fiscal year
R01NS031373Functions of Metabotropic Glutamate Receptor Subtypes342025
R01MH062646Regulation of Signaling by mGluR5202025
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect82025
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders62025
ZIAHD001205Cellular And Synaptic Physiology Of Hippocampal Interneurons52025
R01MH084894Function of GPCR heteromeric complexes in brain42025
T32MH065215Postdoctoral Program in Functional Neurogenomics42025
ZIANS002994Subunit-Specific Regulation Of Glutamate Receptors42025
P30CA016058Cancer Center Support Grant32025
P30ES010126UNC Center for Environmental Health and Susceptibility32025

1 to 10 of 1,231Source NIH's project files

See all 1,231 nih grants

Papers1,307

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated network toxicology and multiomics analyses reveal the mechanisms underlying trimethyltin chloride-induced epilepsy and the ameliorative effects of astaxanthin via NFKB1 and IL6.Ecotoxicol Environ Saf202642810259PubTator, text miningPubMed
Association of metabotropic glutamate receptor 7 gene with nicotine dependence in a Chinese Han population: A cross-sectional candidate-gene association study.Tob Induc Dis202642569468PubTator, text miningPubMed
Retraction notice to "UBTD2 protein molecules emerges as a key prognostic protein marker in glioma: Insights from integrated omics and machine learning analysis of GRM7, NCAPG, CEP55, and other biomarkers" [Int. J. Biol. Macromol. 310 (2025) 143473].
Int J Biol Macromol202642527167PubTator, text miningPubMed
Molecular pharmacology of mGlu7/8 heterodimers reveals unique properties of orthosteric agonists and positive allosteric modulators.Mol Pharmacol202642385300PubTator, text miningPubMed
Inflammation-associated alterations in mGluR transcript expression in the human nucleus accumbens independent of schizophrenia diagnosis.Schizophr Res202642364358PubTator, text miningPubMed
A Novel Intracellular Domain Missense Variant in GRM7 Associated with Early-Onset Neurodevelopmental Encephalopathy.Mol Syndromol202642358513PubTator, text miningPubMed
Therapeutic potential of metabotropic glutamate receptor 7 modulation in correcting cognitive deficits of schizophrenia.Schizophr Res202642308865PubTator, text miningPubMed
Family-Based GWAS of Cognitive Endophenotypes Reveals Genetic Architecture of Memory and Executive Function in Alzheimer's Disease.Curr Issues Mol Biol202642193047PubTator, text miningPubMed
Structural basis for the synaptic adhesion protein ELFN1-mediated modulation of mGlu7.Protein Cell202642172605PubTator, text miningPubMed
Metabotropic glutamate receptors in the testis: An integrative bioinformatic review of neuroendocrine, reproductive, and Neuropsychopharmacological aspects.Prog Neuropsychopharmacol Biol Psychiatry202642134565PubTator, text miningPubMed

1 to 10 of 1,307

See all 1,307 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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