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Gene · 2921

CXCL3: C-X-C motif chemokine ligand 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CXCL3: C-X-C motif chemokine ligand 3. Genes, record 2921. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2921

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Gene

Symbol
CXCL3
HGNC
Name
C-X-C motif chemokine ligand 3
HGNC
NCBI Gene ID
2921
NCBI Gene
HGNC ID
HGNC:4604
HGNC
Ensembl
ENSG00000163734
NCBI Gene
Aliases
CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P19876C-X-C motif chemokine 31072Ensembl, GeneID, HGNC

Source UniProt

Patents135

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026120675 A2026-07-22747P19876Espacenet
EP 4705273 A22026-03-11339P19876Espacenet
JP 2026004568 A2026-01-1441090P19876Espacenet
EP 4650780 A22025-11-193676P19876Espacenet
JP 2025147176 A2025-10-063811P19876Espacenet
JP 2025147176 A2025-10-0616702P19876Espacenet
JP 2025529142 A2025-09-046079P19876Espacenet
US 12371689 B22025-07-296079P19876Espacenet
JP 2025517970 A2025-06-123676P19876Espacenet
JP 2025041681 A2025-03-2626P19876Espacenet

1 to 10 of 135

See all 135 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,607

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCXCL3 papersNewest fiscal year
P30CA016672Cancer Center Support Grant192025
P30CA008748Cancer Center Support Grant182025
P51OD011132Emory National Primate Research Center112025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease82025
P30CA016087Cancer Center Support Grant72025
P30CA010815Consolidated Basic Cancer Research Program62025
P30CA068485Cancer Center Support Grant52025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital52025
UL1TR001863Yale Clinical and Translational Science Award52025
P30AI050409Center for AIDS Research at Emory University42025

1 to 10 of 2,607Source NIH's project files

See all 2,607 nih grants

Papers3,842

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti-PD-1 Therapy.Adv Sci (Weinh)202642801640PubTator, text miningPubMed
Interleukin-24 Induces Inflammatory Chemokine and Cytokine Responses in Fibroblast-Enriched Synovial Cells from Patients with Knee Osteoarthritis.Biomedicines202642792825PubTator, text miningPubMed
Skin Fibroblasts derived from Visceral and Post Kala-Azar Dermal Leishmaniasis patients differentially modulate cytokine and chemokine responses in THP-1 cells.Microb Pathog202642772471PubTator, text miningPubMed
Single-cell transcriptomics reveals a correlation between inflammatory C7 fibroblasts in cervical tumor-adjacent normal tissues and cervical cancer progression.Front Cell Dev Biol202642638795PubTator, text miningPubMed
IL-1β-Induced Inflammatory Transcriptome and TGF-β1 Attenuation of Chemokine Expression in ACL Remnant Fibroblasts.Am J Sports Med202642606104PubTator, text miningPubMed
Inflammation- and stress-related feature screening in recurrent respiratory papillomatosis: A seven-donor single-cell reanalysis with an external laryngeal squamous cell carcinoma transcriptomic context.
Transl Oncol202642580156PubTator, text miningPubMed
CXCL3 deficiency ameliorates COPD by suppressing cigarette smoke-induced NETs formation via MAPK signaling.Mol Immunol202642470888PubTator, text miningPubMed
Inflammatory and Molecular Mechanisms of Adenomyosis Associated Pain: Insights from Multiple Analytic Approaches.J Pain Res202642438819PubTator, text miningPubMed
FGFR2 fusion-driven CXCL3 downregulation attenuates neutrophil recruitment in intrahepatic cholangiocarcinoma.Cancer Lett202642409257PubTator, text miningPubMed
Dissecting cellular heterogeneity across two ocular melanoma subtypes by single-cell RNA sequencing.Melanoma Res202642406542PubTator, text miningPubMed

1 to 10 of 3,842

See all 3,842 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2921

GET https://conductscience.org/api/genes/v1/2921/patents?page=2