ConductScience.org, home

Gene · 2923

PDIA3: protein disulfide isomerase family A member 3

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. PDIA3: protein disulfide isomerase family A member 3. Genes, record 2923. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2923

On this page

Gene

Symbol
PDIA3
HGNC
Name
protein disulfide isomerase family A member 3
HGNC
NCBI Gene ID
2923
NCBI Gene
HGNC ID
HGNC:4606
HGNC
Ensembl
ENSG00000167004
NCBI Gene
Aliases
ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30101Protein disulfide-isomerase A35058Ensembl, GeneID, HGNC

Source UniProt

Patents104

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193998P30101Espacenet
JP 2025147176 A2025-10-0610216P30101Espacenet
JP 2025529142 A2025-09-047312P30101Espacenet
US 12371689 B22025-07-297312P30101Espacenet
JP 2025517970 A2025-06-123998P30101Espacenet
EP 4553160 A12025-05-1410P30101Espacenet
WO 2025093745 A12025-05-08267P30101Espacenet
JP 2025028160 A2025-02-2810216P30101Espacenet
KR 1020250010750 A2025-01-2110216P30101Espacenet
EP 4458349 A12024-11-068P30101Espacenet

1 to 10 of 104

See all 104 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,774

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePDIA3 papersNewest fiscal year
R01AI044115Influences of HLA Class I Polymorphisms on immune responses162025
P30CA008748Cancer Center Support Grant132025
P30CA016672Cancer Center Support Grant112025
P30CA036727Buffett Cancer Center Support Grant102025
R01GM086874Cellular protein maturation and degradation92025
R35GM125034An integrative structural biology approach to understanding metabolite recognition by cellular receptors72025
T32CA009476Cancer Biology Training Program72025
T32HL007917Program in Blood Coagulation and Vascular Biology72025
P30DK020572Michigan Diabetes Research Center (MDRC)62025
R01AI123957Calreticulin-mediated protein folding in health and disease62025

1 to 10 of 1,774Source NIH's project files

See all 1,774 nih grants

Papers3,219

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The impact of low carbohydrate diet on the plasma proteomic profile of individuals with obesity.Front Nutr202642780918PubTator, text miningPubMed
Patient characteristics, treatment patterns, and survival across estrogen receptor expression subgroups in HER2-negative breast cancer: a population-based cohort study.Lancet Reg Health Eur202642724667PubTator, text miningPubMed
Molecular mechanisms of protein disulfide isomerase antagonism by punicalagin.Biochem Biophys Res Commun202642623842PubTator, text miningPubMed
Vitamin D decreases tumor cell growth and invasiveness in primary malignant bone tumors in vitro.J Bone Oncol202642598195PubTator, text miningPubMed
Major capsid protein interacts with protein disulfide isomerase A3 to promote largemouth bass ranavirus adhesion and enhance viral infection.Int J Biol Macromol202642580571PubTator, text miningPubMed
Peptide Loading Complex in Cancer: From Peptide Translocation, Editing, and Loading into MHC-I to a Potential Therapeutic Target.Curr Med Sci202642507253PubTator, text miningPubMed
Exploring tetrahydro-β-carboline derivatives as inhibitors of protein disulfide isomerases A1 and A3.Eur J Med Chem202642475776PubTator, text miningPubMed
Immune-evasion-associated prognostic gene expression score stratifies survival and immune microenvironment features in breast cancer.Biomol Biomed202642403264PubTator, text miningPubMed
Integration of lung tissue proteomics and genome-wide association data to identify lung cancer susceptibility proteins and potential drug targets.medRxiv202642396338PubTator, text miningPubMed
Sperm surface protein disulfide isomerase ERp57 is crucial for mammalian fertilization but functions independently of IZUMO1.Cell Mol Biol Lett202642365233PubTator, text miningPubMed

1 to 10 of 3,219

See all 3,219 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2923

GET https://conductscience.org/api/genes/v1/2923/patents?page=2