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GSK3B: glycogen synthase kinase 3 beta

1 protein, 90 patents, 7 drugs, 109 trials, 15,540 NIH grants and 43,224 papers.

Gene 6

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGSK3BHGNC
Nameglycogen synthase kinase 3 betaHGNC
NCBI Gene ID2932NCBI Gene
HGNC IDHGNC:4617HGNC
EnsemblENSG00000082701NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P49841Glycogen synthase kinase-3 beta420123Ensembl, GeneID, HGNCUniProt

Patents 90

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2025172069 A2025-11-20724P49841Espacenet
EP 4650780 A22025-11-192326P49841Espacenet
EP 4641201 A22025-10-291888P49841Espacenet
JP 2025517969 A2025-06-121888P49841Espacenet
JP 2025517970 A2025-06-122326P49841Espacenet
JP 2025509296 A2025-04-11123P49841Espacenet
US 12252709 B22025-03-182P49841Espacenet
US 12247982 B22025-03-11724P49841Espacenet
EP 4490268 A12025-01-15123P49841Espacenet
US 12130292 B22024-10-2927P49841Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD-1080CHEMBL1969664Glycogen synthase kinase-3 inhibitorINHIBITORChEMBL
ELRAGLUSIBCHEMBL483465Glycogen synthase kinase-3 beta inhibitorINHIBITORChEMBL
LITHIUM CARBONATECHEMBL1200826Glycogen synthase kinase-3 inhibitorINHIBITORChEMBL
LITHIUM CITRATECHEMBL2103738Glycogen synthase kinase-3 inhibitorINHIBITORChEMBL
LITHIUM CITRATE ANHYDROUSCHEMBL1201170Glycogen synthase kinase-3 inhibitorINHIBITORChEMBL
LY-2090314CHEMBL362558Glycogen synthase kinase-3 beta inhibitorINHIBITORChEMBL
TIDEGLUSIBCHEMBL3545157Glycogen synthase kinase-3 beta inhibitorINHIBITORChEMBL

Trials 109

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07540338LITHIUM CARBONATEPHASE1/PHASE2ClinicalTrials.gov
NCT06896188ELRAGLUSIBPHASE1ClinicalTrials.gov
NCT06789783LITHIUM CARBONATEPHASE2/PHASE3ClinicalTrials.gov
NCT06424613LITHIUM CARBONATEClinicalTrials.gov
NCT06184581LITHIUM CARBONATEPHASE4ClinicalTrials.gov
NCT06174220TIDEGLUSIBPHASE2ClinicalTrials.gov
NCT06008249LITHIUM CARBONATEPHASE3ClinicalTrials.gov
NCT05973786LITHIUM CARBONATEPHASE3ClinicalTrials.gov
NCT05923476LITHIUM CARBONATEEARLY_PHASE1ClinicalTrials.gov
NCT05913947LITHIUM CARBONATEPHASE4ClinicalTrials.gov

NIH grants 15540

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1872,025NIH's project files
P30CA008748Cancer Center Support Grant752,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant352,025NIH's project files
R01AA011431FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays312,025NIH's project files
P30CA016058Cancer Center Support Grant292,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase282,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center282,025NIH's project files
P30CA068485Cancer Center Support Grant262,025NIH's project files
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant262,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)262,025NIH's project files

Papers 43224

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827142PubTator, text miningPubMed
42826880PubTator, text miningPubMed
42825974PubTator, text miningPubMed
42825350PubTator, text miningPubMed
42824466PubTator, text miningPubMed
42821047PubTator, text miningPubMed
42818325PubTator, text miningPubMed
42806777PubTator, text miningPubMed
42802970PubTator, text miningPubMed
42802722PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license