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GSR: glutathione-disulfide reductase

1 protein, 40 patents, 2 drugs, 199 trials, 3,956 NIH grants and 18,565 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGSRHGNC
Nameglutathione-disulfide reductaseHGNC
NCBI Gene ID2936NCBI Gene
HGNC IDHGNC:4623HGNC
EnsemblENSG00000104687NCBI Gene
AliasesCNSHA10, GR, GRase, GSRD, HEL-75, HEL-S-122mNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P00390Glutathione reductase, mitochondrial52227Ensembl, GeneID, HGNCUniProt

Patents 40

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447880P00390Espacenet
EP 4650780 A22025-11-19497P00390Espacenet
EP 4641201 A22025-10-29346P00390Espacenet
JP 2025517969 A2025-06-12346P00390Espacenet
JP 2025517970 A2025-06-12497P00390Espacenet
JP 2025081326 A2025-05-2744P00390Espacenet
US 12006548 B22024-06-11357P00390Espacenet
US 11446398 B22022-09-2035325P00390Espacenet
JP 2022524081 A2022-04-27138296P00390Espacenet
US 11078247 B22021-08-034766P00390Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CARMUSTINECHEMBL513Glutathione reductase inhibitorINHIBITORChEMBL
OXIGLUTATIONECHEMBL1372Glutathione reductase otherOTHERChEMBL

Trials 199

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06915246CARMUSTINEPHASE2ClinicalTrials.gov
NCT06652165CARMUSTINEPHASE2ClinicalTrials.gov
NCT06377540CARMUSTINEPHASE2ClinicalTrials.gov
NCT05931263CARMUSTINEPHASE3ClinicalTrials.gov
NCT05863845CARMUSTINEClinicalTrials.gov
NCT05814718CARMUSTINEClinicalTrials.gov
NCT05681403CARMUSTINEClinicalTrials.gov
NCT05367856CARMUSTINEPHASE2ClinicalTrials.gov
NCT05228249CARMUSTINEPHASE1ClinicalTrials.gov
NCT05083754CARMUSTINEPHASE1ClinicalTrials.gov

NIH grants 3956

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA086862Cancer Center Support Grant272,025NIH's project files
P30ES005605Environmental Health Sciences Research Center202,025NIH's project files
P30CA016672Cancer Center Support Grant142,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)112,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center112,025NIH's project files
P42ES013661Iowa Superfund Research Program: Airborne PCBs: Sources, Exposures, Toxicities, Remediation112,025NIH's project files
P30CA008748Cancer Center Support Grant92,025NIH's project files
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity92,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant82,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)82,025NIH's project files

Papers 18565

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822111PubTator, text miningPubMed
42792844PubTator, text miningPubMed
42792233PubTator, text miningPubMed
42790823PubTator, text miningPubMed
42775241PubTator, text miningPubMed
42770141PubTator, text miningPubMed
42758390PubTator, text miningPubMed
42757385PubTator, text miningPubMed
42757067PubTator, text miningPubMed
42753553PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license