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Gene · 2937

GSS: glutathione synthetase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GSS: glutathione synthetase. Genes, record 2937. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2937

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Gene

Symbol
GSS
HGNC
Name
glutathione synthetase
HGNC
NCBI Gene ID
2937
NCBI Gene
HGNC ID
HGNC:4624
HGNC
Ensembl
ENSG00000100983
NCBI Gene
Aliases
CNSHA6, GSHS, HEL-S-64p, HEL-S-88n
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48637Glutathione synthetase4742Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21159P48637Espacenet
JP 2026004568 A2026-01-1447933P48637Espacenet
KR 1020250176604 A2025-12-222P48637Espacenet
EP 4650780 A22025-11-1919372P48637Espacenet
JP 2025517970 A2025-06-1219372P48637Espacenet
US 11718832 B22023-08-0813P48637Espacenet
JP 2023521663 A2023-05-25158P48637Espacenet
US 11446398 B22022-09-2035423P48637Espacenet
JP 2022524081 A2022-04-27138394P48637Espacenet
JP 2021530985 A2021-11-18266P48637Espacenet

1 to 10 of 40

See all 40 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,320

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGSS papersNewest fiscal year
P30ES006694Southwest Environmental Health Sciences Center92025
P30CA016672Cancer Center Support Grant82025
P30CA008748Cancer Center Support Grant72025
P30CA086862Cancer Center Support Grant72025
R01ES010563Mechanisms of Manganese Neurotoxicity72025
P42ES013661Iowa Superfund Research Program: Airborne PCBs: Sources, Exposures, Toxicities, Remediation62025
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025
P30ES005605Environmental Health Sciences Research Center42025
P30ES007048Environmental Exposures, Host Factors and Human Disease42025

1 to 10 of 1,320Source NIH's project files

See all 1,320 nih grants

Papers2,985

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting GSS-mediated glutathione synthesis: 6-Met induces oxidative stress dependent apoptosis via triggering mitochondrial bioenergetics metabolism crisis and mTOR suppression in glioblastoma.Redox Biol202642617573PubTator, text miningPubMed
Multi-omics analysis of the rhizosphere effects and molecular mechanisms of Ageratum conyzoides linn. at different stages of Cd, Pb, and Zn co-stress.J Environ Manage202642485963PubTator, text miningPubMed
Redox Imbalance and Impaired Protein Clearance Drive Chronic Liver Injury in Biliary Atresia.J Surg Res202642419058PubTator, text miningPubMed
Shared genetic architecture of Parkinson's disease and cutaneous melanoma: Heterogeneous pleiotropy and Colocalization at the SOX6 locus.Prog Neuropsychopharmacol Biol Psychiatry202642335983PubTator, text miningPubMed
Cell size modulates ferroptosis susceptibility.Elife202642267631PubTator, text miningPubMed
Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction.Elife202642262974PubTator, text miningPubMed
The role of STAT3-targeted therapy created with COLIVELIN in the cross-talk between IL6/JAK2/STAT3 and TGF-β/SMAD2/SMAD3 signaling in a hyperinflammation and ROS-induced in vitro AMD model and its effect on retinal apoptosis.
Int Ophthalmol202642240907PubTator, text miningPubMed
Lens tissue transcriptome analysis in patients with total congenital cataract.Hum Genomics202642192484PubTator, text miningPubMed
Novel NSAID Analogs Exhibit Anti-Leukemic Activity Through Modulation of Apoptotic and Survival Pathways.Int J Mol Sci202642123436PubTator, text miningPubMed
Impaired pathways of detoxification and risk of Alzheimer's disease: Differential gene expression studies via gene set expression analysis.J Alzheimers Dis Rep202642079451PubTator, text miningPubMed

1 to 10 of 2,985

See all 2,985 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2937

GET https://conductscience.org/api/genes/v1/2937/patents?page=2