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Gene · 2959

GTF2B: general transcription factor IIB

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GTF2B: general transcription factor IIB. Genes, record 2959. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2959

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Gene

Symbol
GTF2B
HGNC
Name
general transcription factor IIB
HGNC
NCBI Gene ID
2959
NCBI Gene
HGNC ID
HGNC:4648
HGNC
Ensembl
ENSG00000137947
NCBI Gene
Aliases
TF2B, TFIIB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q00403Transcription initiation factor IIB31655Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4698657 A22026-02-25381Q00403Espacenet
JP 2026004568 A2026-01-1447477Q00403Espacenet
EP 4650780 A22025-11-198788Q00403Espacenet
EP 4641201 A22025-10-298997Q00403Espacenet
JP 2025517969 A2025-06-128997Q00403Espacenet
JP 2025517970 A2025-06-128788Q00403Espacenet
JP 2025032204 A2025-03-1129449Q00403Espacenet
EP 4461818 A22024-11-1329449Q00403Espacenet
JP 2023058610 A2023-04-2529449Q00403Espacenet
US 11446398 B22022-09-2034402Q00403Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,295

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGTF2B papersNewest fiscal year
P01CA013106Targeting Transcription and Splicing in Cancer102025
R01AI030612Virus-cell interactions affecting HSV gene expression82025
P30CA014051Cancer Center Support (Core) Grant72025
R35GM139550Mechanisms of RNA polymerase II transcription regulation62025
P30CA015704Cancer Center Support Grant52025
R01GM074701Interplay Between Chromatin and Co-Activator Complexes52025
P01CA022443Molecular Biology and Genetics of Human Tumor Viruses42025
P30CA008748Cancer Center Support Grant42025
P30CA010815Consolidated Basic Cancer Research Program42025
P30CA046934University of Colorado Cancer Center Support Grant42025

1 to 10 of 1,295Source NIH's project files

See all 1,295 nih grants

Papers1,958

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Promoter contacts by TFB and TFEα during archaeal transcription initiation.Transcription202642446406PubTator, text miningPubMed
Ecological and evolutionary implications of a mobile genetic element-rich haloarchaeon with unique osmotic resilience.Microbiol Spectr202642379816PubTator, text miningPubMed
Integrated Proteomic Profiling of Whole-Cell and Multi-Post-Translational Modifications Unveils Regulatory Networks in Macrophage Inflammatory Responses.J Proteome Res202642316966PubTator, text miningPubMed
Bound for the nucleus: defining the molecular principles of cargo selection by importin 9.bioRxiv202642182196PubTator, text miningPubMed
Cleavage of the RNA polymerase II general transcription factor TFIIB tunes transcription during stress.Genes Dev202642128667PubTator, text miningPubMed
ReDisulphID: A discovery platform for thiol redox sensors identifies a druggable site regulating p53 activation.Redox Biol202642097034PubTator, text miningPubMed
Monkeypox virus protein OPG188 antagonizes cGAS-STING antiviral signaling pathway to mediate immune evasion.Proc Natl Acad Sci U S A202641849394PubTator, text miningPubMed
Asgard archaea: have we found our microbial ancestors?EMBO J202641787125PubTator, text miningPubMed
Cooperative clamp-mediated promoter recognition by poxviral RNA polymerase and its TBP/TFIIB-like partner.Nat Commun202641708602PubTator, text miningPubMed
Emerging insights into enhancer RNAs: biogenesis, function, mechanism, and disease implication.Brief Bioinform202641652928PubTator, text miningPubMed

1 to 10 of 1,958

See all 1,958 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/2959

GET https://conductscience.org/api/genes/v1/2959/patents?page=2