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Gene · 2969

GTF2I: general transcription factor IIi

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GTF2I: general transcription factor IIi. Genes, record 2969. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/2969

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Gene

Symbol
GTF2I
HGNC
Name
general transcription factor IIi
HGNC
NCBI Gene ID
2969
NCBI Gene
HGNC ID
HGNC:4659
HGNC
Ensembl
ENSG00000263001
NCBI Gene
Aliases
BAP-135, BAP135, BTKAP1, DIWS, GTFII-I, IB291, SPIN, TFII-I, WBS, WBSCR6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P78347General transcription factor II-I9984Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447519P78347Espacenet
EP 4650780 A22025-11-1917343P78347Espacenet
EP 4641201 A22025-10-2921408P78347Espacenet
JP 2025147176 A2025-10-0615060P78347Espacenet
JP 2025517969 A2025-06-1221408P78347Espacenet
JP 2025517970 A2025-06-1217343P78347Espacenet
JP 2025028160 A2025-02-2815060P78347Espacenet
KR 1020250010750 A2025-01-2115060P78347Espacenet
JP 2024109657 A2024-08-1414899P78347Espacenet
US 11446398 B22022-09-2034473P78347Espacenet

1 to 10 of 39

See all 39 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,154

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGTF2I papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30CA016672Cancer Center Support Grant82025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant42025
P30CA047904Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30DK020593Vanderbilt Diabetes Research Center32025
P50HD103525WASHINGTON UNIVERSITY INTELLECTUAL AND DEVELOPMENTAL DISABILITIES RESEARCH CENTER32025
T32MH019908Research Training for Child Psychiatry and Neurodevelopment32025
U54GM104938Oklahoma Shared Clinical and Translational Resources32025
K12GM068524San Diego IRACDA Scholars Program22025

1 to 10 of 1,154Source NIH's project files

See all 1,154 nih grants

Papers1,337

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic Heterogeneity in Autism Spectrum Disorder: Diagnostic Yield, Recurrent Genes, and Rare Variant-Phenotype Associations from Whole-Exome Sequencing.Int J Mol Sci202642589554PubTator, text miningPubMed
Yes-Associated Protein (YAP)1 and β-Catenin Immunohistochemistry as a Surrogate Marker for GTF2I-Mutant Type A/AB Thymomas.Mod Pathol202642586240PubTator, text miningPubMed
Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa-Cell Programs.FASEB J202642541334PubTator, text miningPubMed
[Clinicopathological analysis of 28 cases of micronodular thymic tumours with lymphoid stromal hyperplasia].Zhonghua Zhong Liu Za Zhi202642477929PubTator, text miningPubMed
The glutathione transferase omega 1-1 GSTO1∗A140D polymorphism is associated with unfavourable prognosis in patients with thymoma and myasthenia gravis.Adv Med Sci202642303225PubTator, text miningPubMed
Distinct Associations of GTF2I, TP53, and NOTCH1 Variants with Indolent and Aggressive Thymic Epithelial Tumors in Vietnamese Patients.Genes (Basel)202642194981PubTator, text miningPubMed
Immune-related markers define clinically relevant prognostic subgroups in thymic epithelial tumors.Lung Cancer202642091015PubTator, text miningPubMed
The ZMIZ1-GTF2I interaction as a potential contributor to the neurodevelopmental phenotype in neurodevelopmental disorder with dysmorphic facies and distal skeletal anomalies (NEDDFSA).Pediatr Res202641981097PubTator, text miningPubMed
Plasma heme pool compartmentalization is linked to pathophysiology in Sickle Cell Disease.PLoS One202641886505PubTator, text miningPubMed
Modeling Williams syndrome from a neurodevelopmental perspective: recent advances, model-based translational insights and future directions.World J Pediatr202641845159PubTator, text miningPubMed

1 to 10 of 1,337

See all 1,337 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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